OLS : Record


Main Title Addendum to the health assessment document for trichloroethylene : updated carcinogenicity assessment for trichloroethylene.
Author Beliles, R. P.; Chen, C. W.; Gibb, H. J.; Parker, J. C.; Ris, C. H.
CORP Author United States. Environmental Protection Agency. Office of Research and Development.
Publisher Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Place Published Washington, D.C.
Year Published 1987
Report Number EPA/600/8-82/006FA
Stock Number PB87-228045
OCLC Number 16521806
Subjects Environmental health; Trichloroethylene--Toxicology; Industrial medicine; Exposure; Residues; Humans; Laboratory animals; Teratogens; Carcinogens; Physiological effects; Ethylene/trichloro; Air pollution effects(Humans); Occupational safety and health; Toxic substances
Subject Added Ent Environmental health.; Trichloroethylene--Toxicology.
Internet Access
Description Access URL
Library   Call Number Additional Info Location Date Modified
EIAD EPA/600/8-82/006FA Region 2 Library/New York,NY 04/23/2004
EJAD EPA 600/8-82/006FA Region 3 Library/Philadelphia, PA 10/29/1993
EJBD ARCHIVE EPA 600-8-82-006FA Headquarters Library/Washington,DC 11/17/2014
EJBD EPA 600-8-82-006FA Headquarters Library/Washington,DC 11/04/2005
EKAM EPA/600/8-82/006FA Region 4 Library/Atlanta,GA 03/18/1994
EKBD EPA-600/8-82-006FA Research Triangle Park Library/RTP, NC 01/01/1988
ELBD EPA/600/8-82/006FA AWBERC Library/Cincinnati,OH 01/28/1989
EOBD EPA 600-8-82-006FA NEIC Library/Denver,CO 11/05/1999
ERAD EPA 600/8-82-006FA Region 9 Library/San Francisco,CA 02/19/2013
ESAD EPA 600-8-82-006FA Region 10 Library/Seattle,WA 07/29/2005
NTIS PB87-228045 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 1 volume (various pagings) : charts ; 28 cm
Abstract The addendum updates the Health Assessment Document (HAD) for Trichloroethylene (TCI) published in July 1986. The addendum focuses on the inhalation and oral carcinogenicity bioassays that have become available since the 1985 HAD was completed. The 1985 HAD concluded that the available carcinogenicity evidence for TCI was, according to EPA's Guidelines for Carcinogen Risk Assessment, inadequate in humans, and sufficient in animals, thus equivalent to a weight-of-evidence classification of Group B2. The conclusion was based primarily on mouse liver tumor responses, with support from metabolism data and other positive but compromised bioassay studies. The addendum identifies positive findings in rats, a second species, and positive findings by inhalation exposure in rats and mice with both similar and different tumor sites compared to the oral studies. A quantitative analysis of the recently reported inhalation studies shows that the upper-bound estimate of risk is very close to the earlier inhalation estimate in the 1985 HAD derived from the oral studies. The recommended upper-bound incremental unit risk for humans exposed for a 70-year lifetime to a 1 micrograms/cu. m. airborne concentration of TCI is 1.7 times 10 to the minus 6 power.
Notes "EPA/600/8-82/006FA"--Cover. "June 1987"--Cover. "External Review Draft"--Cover. "Review draft (Do Not Cite or Quote)"--Cover. "Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency"--Cover. This document was prepared by the following members of the Carcinogen Assessment Group, Office of health and Environmental Assessment. Authors: Robert P. Beliles, Ph.D., D.A.B.T., Chao W. Chen, Ph.D., Herman J. Gibb, B.S., M.P.H., Jean C. Parker, Ph.d., Charles H. Ris, M.S.S.E.
Supplementary Notes See also PB83-135970.
Author Added Ent
Beliles, Robert P.,;
Chen, Chao W.,;
Gibb, Herman J.,;
Parker, Jean C.,;
Ris, Charles H.,
Corporate Au Added Ent United States. Environmental Protection Agency. Office of Research and Development,; United States. Environmental Protection Agency. Office of Health and Environmental Assessment. Carcinogen Assessment Group,
Alternate Title Health assessment document for trichloroethylene
PUB Date Free Form June 1987
Ti Tra Differently Health assessment document for trichloroethylene.
NTIS Prices PC A07/MF A01
BIB Level m
Document Type BC
Medium unmediated
OCLC Time Stamp 20141112091257
Cataloging Source RDA
Language eng
Origin OCLC
Type CAT
OCLC Rec Leader 02420cam 2200457Ki 45020