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RECORD NUMBER: 4 OF 49

Main Title Comparative Immunosuppression of Various Glycol Ethers Orally Administered to Fisher 344 Rats.
Author Smialowicz, R. J.; Williams, W. C.; Riddle, M. M.; Andrews, D. L.; Luebke, R. W.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/230;
Stock Number PB92-195833
Subjects Toxicology; Immunosuppression; Antibody formation; Lipopolysaccharides; Rats; Alcohol dehydrogenase; Enzyme inhibitors; Ethylene glycol; Reprints; Glycol ethers; 4-methylpyrazole
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB92-195833 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/22/1992
Collation 9p
Abstract Oral dosing of adult male F344 rats with the glycol ether 2-methoxyethanol (ME) or its principal metabolite 2-methoxyacetic acid (MAA) results in the suppression of the primary plaque-forming cell (PFC) response to trinitrophenyl-lipopolysaccharide (TNP-LPS). In the present study, the PFC response to TNP-LPS was used to evaluate the immunotoxic potential of ethylene glycol (EG) as well as the glycol ethers 2-methoxyethyl acetate (MEA), 2-(2-methoxyethoxy) ethanol, bis(2-methoxyethyl) ether, 2-ethoxyethanol and its principal metabolite 2-ethoxyacetic acid, 2-ethoxyethyl acetate, and 2-butoxyethanol relative to ME and MAA. Rats were immunized with TNP-LPS and then exposed 4 and 28 hr later to 50, 100, 200, or 400 mg/kg of glycol ether or EG. Three days following immunization, the PFC response to TNP-LPS was determined. In addition to ME and MAA, only MEA, which was as effective as ME, suppressed the PFC response to TNP-LPS. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. (Copyright (c) 1992 by the Society of Toxicology.)
Supplementary Notes Pub. in Fundamental and Applied Toxicology 18, n4 p621-627 May 92. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Comparative Immunosuppression of Various Glycol Ethers Orally Administered to Fisher 344 Rats.
Category Codes 57Y; 57J
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 221932933
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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