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RECORD NUMBER: 38 OF 2305

Main Title Addendum to the health assessment document for dichloromethane (methylene chloride) : updated carcinogenicity assessment of dichloromethane (methylene chloride) /
Author Singh, Dharm V.
CORP Author United States. Environmental Protection Agency. Office of Research and Development.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Place Published Washington D.C.
Year Published 1985
Report Number EPA-600/8-82-004FF; EPA/600/8-82/004ff
Stock Number PB86-123742
OCLC Number 13765008
Subjects Environmental health; Dichloromethane--Toxicology; Carcinogens; Hazardous materials; Industrial hygiene; Toxicology; Environmental surveys; Chloromethanes; Assessments; Exposure; Water pollution; Air pollution; Surface waters; Potable water; Mutagens; Epidemiology; Laboratory animals; Methane/dichloro; Water pollution effects(Human); Occupational safety and health; Toxic substances; Environmental health; Cancer; Water pollution effects(Animals)
Subject Added Ent Environmental health.; Dichloromethane--Toxicology.; Carcinogens.
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=2000BF0O.txt
http://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=300016WQ.txt
Holdings
Library   Call Number Additional Info Location Date Modified
EJBD ARCHIVE EPA 600-8-82-004FF Headquarters Library/Washington,DC 11/09/2009
EMBD EPA/600/8-82/006FA GWERD Library/Ada,OK 02/17/1995
EOAD EPA 600/8-82-004FF Region 8 Technical Library/Denver,CO 05/23/2011
ERAD EPA 600/8-82-004FF Region 9 Library/San Francisco,CA 06/29/1990
ESAD EPA 600-8-82-004FF Region 10 Library/Seattle,WA 07/29/2005
NTIS PB86-123742 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation vii, 113 p. : ill. ; 28 cm.
Abstract The addendum contains a review of the data from the latest National Toxicology Program (NTP) inhalation bioassay of dichloromethane (DCM) and an update of the inhalation cancer risk value. In addition, there is a recommendation for an estimate of unit risk for ingestion exposure, and an evaluation of metabolism and pharmacokinetic data for use in the development of cancer unit risk estimates. The recent NTP inhalation bioassay concluded that there was some evidence of carcinogenicity for male F344/N rats and clear evidence of carcinogenicity for female F344/N rats as shown by increased evidence of benign neoplasms of the mammary gland. There was clear evidence of carcinogenicity for male and female B6C3F1 mice as shown by increased incidence of alveolar/bronchiolar neoplasms and of hepatocellular neoplasms. There are data from two epidemiologic studies associated with exposure to DCM. Neither showed excessive risk to cancer, but each was considered to have sufficient limitations which prevent them from being judged negative studies. A review of the metabolism/pharmacokinetics concluded that possible approaches for interpreting the data are more illustrative than useful in risk estimation. Using EPA's Proposed Guidelines for Carcinogen Risk Assessment, there is a sufficient weight-of-evidence that DCM is a possible carcinogen in experimental animals, but for humans the data are inadequate. Therefore, DCM is classified, according to the Guidelines, as Category B2, i.e., a possible human carcinogen.
Notes "EPA/600/8-82/004FF." "September 1985." "Final Report." Includes bibliographies.
Supplementary Notes See also PB85-191559.
Author Added Ent
Spitzer, Hugh L.;
White, Paul Dudley,
Corporate Au Added Ent United States. Environmental Protection Agency. Office of Research and Development.
PUB Date Free Form 1985
NTIS Prices PC A06/MF A01
BIB Level m
Document Type BC
OCLC Time Stamp 20110517151302
Cataloging Source OCLC/T
Language eng
Origin OCLC
Type CAT
OCLC Rec Leader 01168cam 2200301Ia 45020


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