| Main Title |
Alpha-2u-globulin association with chemically induced renal toxicity and neoplasia in the male rat / {microform} : |
| Author |
Baetcke, K. P.;
Hard, G. C.;
Rodgers, I. S.;
McGaughy, R. E.;
Tahan, L. M.
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, |
| Place Published |
Washington, D.C. : |
| Year Published |
1991 |
| Report Number |
EPA/625/3-91/019F; OHEA-F-385 |
| Stock Number |
PB92-143668 |
| OCLC Number |
45865293 |
| Subjects |
Toxicity;
Kidney;
Kidney neoplasms;
Rats;
Carcinogens;
Males;
Risk assessment;
Kidney diseases;
Dose-response relationships;
Species specificity;
Alpha 2-microglobulins
|
| Subject Added Ent |
Risk assessment;
Alpha globulin
|
| Internet Access |
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| ERBD |
|
PB92-143668 |
|
NERL/ESD-LV Library/Las Vegas,NV |
02/09/2001 |
| NTIS |
|
PB92-143668 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
01/01/1988 |
|
| Collation |
132 p. ; 28 cm. |
| Abstract |
The report of a Technical Panel of the U.S. Environmental Protection Agency (EPA) Risk Assessment Forum describes conditions under which the Forum advises EPA risk assessors against using information on certain renal tubule tumors or nephrotoxicity to assess human risk. Risk assessment approaches generally assume that chemicals producing tumors in laboratory animals are a potential cancer hazard to humans. For most chemicals, including many rodent kidney carcinogens, this extrapolation remains appropriate. The scientific studies reviewed by the Technical Panel indicate, however, that some other chemicals induce accumulation of alpha(sub 2u)-globulin, a low-molecular-weight protein, in the male rat kidney. Female rats and other laboratory mammals administered the same chemicals do not accumulate low-molecular-weight protein in the kidney and they do not develop renal tubule tumors. Since humans appear to be more like other laboratory animals than like the male rat, in this special situation, the male rat is not a good model for assessing human risk. |
| Notes |
"Risk Assessment Forum." "EPA/625/3-91/019F." "September 1991." Microfiche. |
| Author Added Ent |
|
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Risk Assessment Forum. |
| PUB Date Free Form |
1991. |
| Ti Tra Differently |
Association with chemically induced renal toxicity and neoplasia in the male rat. |
| NTIS Prices |
PC A07/MF A02 |
| BIB Level |
m |
| OCLC Time Stamp |
20010207140153 |
| Cataloging Source |
OCLC/T |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01185nam 2200289Ka 45020 |
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