OLS : Record

RECORD NUMBER: 3 OF 933

Main Title

2-Methylhexanoic Acid Developmental Toxicity Testing.

Author

CORP Author

ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.

Publisher

Jun 91

Year Published

1991

Report Number

EPA-68-02-4450; EPA/600/1-91/002;

Stock Number

PB91-197418

Subjects

Toxicity; Reproduction(Biology); Teratogens; Dose-response relationships; Survival; Skeleton; Weight loss; Respiration; Tables(Data); Rats; 2-Methylhexanoic acid

Holdings

Library		Call Number	Additional Info	Location	Date Modified
NTIS		PB91-197418	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.	NTIS	09/04/1991

Collation

22p

Abstract

As part of an investigation of the developmental effects and structure-activity relationships of aliphatic acids, 2-methylhexanoic acid was administered by gavage to Sprague-Dawley rats on gestation days 6-15 at doses of 0, 300, and 400 mg/kg/day. The dams were allowed to deliver and their litters were examined through postnatal day 6. Pups that were found dead were examined for soft-tissue alterations. On day 6, two survivors per litter were preserved for skeletal examination. Maternal toxicity was demonstrated at both 300 and 400 mg/kg by weight loss and altered respiration (rales, dyspnea). In spite of the maternal toxicity present, there were no clear toxic effects on development; litter size, pre- and postnatal viability, and pup weights were unaffected by treatment. Skeletal examinations of selected pups yielded inconclusive data; a slight increase in the incidence of lumbar ribs was present a 400 mg/kg, but was not clearly attributable to treatment.

Supplementary Notes

Sponsored by Health Effects Research Lab., Research Triangle Park, NC.

Category Codes

57Y; 57S

NTIS Prices

PC A03/MF A01

Primary Description

600/10

Document Type

Control Number

120725616

Cataloging Source

NTIS/MT

Origin

NTIS

Type

CAT

OLS : Record

RECORD NUMBER: 3 OF 933

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