OLS : Record

RECORD NUMBER: 3 OF 41

Main Title Assessment of the carcinogenicity of dicofol (Kelthane{TM}), DDT, DDE, and DDD (TDE) {microform} /
Author Holder, James W.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Place Published Washington, D.C. :
Year Published 1986
Report Number EPA/600/6-86/001
Stock Number PB87-110904
OCLC Number 48744299
Subjects Toxicity; Hazardous materials; Assessments; Carcinogens; Malignant neoplasms; Epidemiology; Pesticides; Persistence; Neoplasms; Concentration(Composition); Chlorine organic compounds; Toxic substances; Environmental health; Carcinogenesis; DDT; DDE insecticide; DDD insecticide; Dicofol
Subject Added Ent Pesticides--Toxicology; Carcinogenicity testing--United States; Liver Neoplasms--chemically induced; Pesticides--toxicity; Carcinogenicity Tests
Holdings
Library   Call Number Additional Info Location Date Modified
ERBD PB87-110904 NERL/ESD-LV Library/Las Vegas,NV 01/11/2002
NTIS PB87-110904 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 85 p. ; 28 cm.
Abstract The carcinogenic activity of the pesticides dicofol and associated pesticide compounds DDT, DDE, and DDD are reviewed. All of these compounds exhibit carcinogenic activity in surrogate test animals. DDT is judged on the bases of these biotests, positive mutagenicity in vivo, two-stage chemical carcinogenesis tests, and the lack of relevant epidemiological tests to be probably carcinogenic to man. Dicofol, DDT, DDE, DDD animal test data, when analyzed by the linearized multistage model for low-dose extrapolation, show similar cancer potencies: q*1 = 0.44, 0.34, 0.34, 0.25, respectively,/(mg/kg/day). Such similiarity in cancer potency values suggests that either a common carcinogenic metabolite is generated from these compounds, or each compound has intrinsic carcinogenic activity and need not be metabolized to any other compound in order to cause cancer.
Notes Photocopy. Microfiche.
Title Ser Add Ent PB (Series) ;
PUB Date Free Form {1986}
Series Title Untraced PB ; EPA ; 87-110904 600/6-86/001
NTIS Prices PC A05/MF A01
BIB Level m
OCLC Time Stamp 20020107183316
Cataloging Source OCLC/T
Language eng
Origin OCLC
Type MERGE
OCLC Rec Leader 01203nam 2200313Ka 45020