OLS : Record

RECORD NUMBER: 43 OF 102

Main Title Intraperitoneal Dc 360 Fluid, Injected in Rats - Nyu Medical Center with Cover Letter dated 04/20/94.
CORP Author Food and Drug Research Labs., Inc., Waverly, NY.; Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 8EHQ-86940001235
Stock Number OTS0572244
Subjects Toxicology; Health effects; DC 360 Fluid; Toxicity; Acute toxicity; Mammals; Rats; Parenteral; Intraperitoneal; CAS No 63148-62-9; Dc 360 Fluid (CAS No 63148-62-9); Toxic substances; Laboratory animals
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS OTS0572244 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 19p
Abstract The purpose of this study was to evaluate the effects of single large intraperitoneal doses of polydimethylsiloxane fluid. CFN strain rats were administered 0, 51, or 62 ml of the test substance per animal injected intraperitoneally. Smaller doses were given to other groups of rats, however, these rats did not undergo pathological evaluation. Approximately 1 year after administration, the animals in the 51 and 62 ml dose group were sacrificed and gross necropsy and histopathology were performed. Evaluations revealed invasion of the parenchymal organs in the peritoneal cavity by the test substance. Foci of crypting in the liver with demarcated cavities was reported. The pancreas was almost completely replaced by a fatty substance, however, these reactions were not accompanied by any significant foreign body reactions. Based on these observations, the pathological findings are volume related tissue degradation associated with the intraperitoneal injection of large doses of polydimethylsiloxane.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Dow Corning Corp., Midland, MI.
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PUB Date Free Form 1994
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A03/MF A03
Document Type NT
Control Number 028804040
Cataloging Source NTIS/MT
Origin NTIS
Type CAT