OLS : Record

RECORD NUMBER: 43 OF 102

Main Title

Intraperitoneal Dc 360 Fluid, Injected in Rats - Nyu Medical Center with Cover Letter dated 04/20/94.

CORP Author

Food and Drug Research Labs., Inc., Waverly, NY.; Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.

Year Published

1994

Report Number

8EHQ-86940001235

Stock Number

OTS0572244

Subjects

Toxicology; Health effects; DC 360 Fluid; Toxicity; Acute toxicity; Mammals; Rats; Parenteral; Intraperitoneal; CAS No 63148-62-9; Dc 360 Fluid (CAS No 63148-62-9); Toxic substances; Laboratory animals

Holdings

Library		Call Number	Additional Info	Location	Date Modified
NTIS		OTS0572244	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.	NTIS	03/10/2010

Collation

19p

Abstract

The purpose of this study was to evaluate the effects of single large intraperitoneal doses of polydimethylsiloxane fluid. CFN strain rats were administered 0, 51, or 62 ml of the test substance per animal injected intraperitoneally. Smaller doses were given to other groups of rats, however, these rats did not undergo pathological evaluation. Approximately 1 year after administration, the animals in the 51 and 62 ml dose group were sacrificed and gross necropsy and histopathology were performed. Evaluations revealed invasion of the parenchymal organs in the peritoneal cavity by the test substance. Foci of crypting in the liver with demarcated cavities was reported. The pancreas was almost completely replaced by a fatty substance, however, these reactions were not accompanied by any significant foreign body reactions. Based on these observations, the pathological findings are volume related tissue degradation associated with the intraperitoneal injection of large doses of polydimethylsiloxane.

Supplementary Notes

The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Dow Corning Corp., Midland, MI.

Availability Notes

Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.

PUB Date Free Form

1994

Category Codes

57Y; 57U; 68G; 99; 44G

NTIS Prices

PC A03/MF A03

Document Type

Control Number

028804040

Cataloging Source

NTIS/MT

Origin

NTIS

Type

CAT

OLS : Record

RECORD NUMBER: 43 OF 102

Local Navigation