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RECORD NUMBER: 24 OF 103

Main Title Combined Effects of Solvents on the Rat's Auditory System: Styrene and Trichloroethylene.
Author Rebert, C. S.; Boyes, W. K.; Pryor, G. T.; Svensgaard, D. J.; Kassay, K. M.;
CORP Author SRI International, Menlo Park, CA. Neuroscienc Dept.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/339;
Stock Number PB93-229573
Subjects Solvents; Styrene; Trichloroethylene; Hearing loss; Dose-response relationships; Auditory evoked potentials; Rats; Hair cells; Cochlea; Statistical analysis; Blood chemical analysis; Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB93-229573 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 13p
Abstract Because exposures to toxic agents typically involve more than one substance, it is necessary to know if combined exposures pose different risks than those to single agents. Many solvents have been implicated in central nervous disorders and some of them are known to produce hearing loss, probably mediated by damage to cochlear hair cells. Hearing loss was studied by recording the brainstem auditory evoked response (BAER) in male Long Evans rats exposed 8 h/day for 5 days to mixtures of styrene (STY) and trichloroethylene (TCE). Dose groups included air or solvent pairs (STY/TCE) in the following concentrations (ppm): (0:3000), (250:2250), (500:1500), (750:750) and (1000:0). Decreased BAER amplitude, indicative of hearing loss, was correlated with blood levels of total solvent. The effects were as predicted by a linear dose-addition model, indicating neither synergistic nor antagonistic interactions at the concentrations studied. (Copyright (c) 1993 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Jnl. of Psychophysiology, v14 n2 p49-59 1993. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Combined Effects of Solvents on the Rat's Auditory System: Styrene and Trichloroethylene.
Category Codes 57Y; 57S; 57I
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 328023543
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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