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RECORD NUMBER: 20 OF 62

Main Title Effect of Nongenotoxic Environmental Contaminants on Cholesterol and DNA Synthesis in Cultured Primary Rat Hepatocytes.
Author Reddy, T. V.; Chang, L. W.; DeAngelo, A. B.; Pereira, M. A.; Daniel, F. B.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Cincinnati, OH.
Publisher 1993
Year Published 1993
Report Number EPA/600/J-93/396;
Stock Number PB93-236339
Subjects Liver; Environmental pollutants; Cholesterol; DNA replication; Rats; Cultured cells; Biological models; Cell division; Biosynthesis; Chlorinated hydrocarbons; Dimethyl sulfoxide; Epidermal growth factor-urogastrone; Phenobarbital; Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB93-236339 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 13p
Abstract The effects of certain reputedly non-genotoxic agents on cholesterol and DNA synthesis were investigated in cultured primary rat hepatocytes and in liver slices. Hepatocytes in culture were incubated for 48, 60, and 72 hours with one of the following chemicals: chloroform (CHCl3); 1,1,2-trichloroethane (TCE); trichloroacetic acid (TCA); dichloroacetic acid (DCA); monochloroacetic acid (MCA); di(2-ethylhexyl)phthalate (DEHP); mono(ethylhexyl)phthalate (MEHP); phenobarbital (PB); epidermal growth factor (EGF); dimethylsulfoxide (DMSO). All test chemicals stimulated cholesterol and DNA synthesis in the cultures. However, the induction of DNA synthesis in hepatocytes treated with DCA became apparent by sixty hours.
Supplementary Notes Pub. in Environmental Sciences, v1 n4 p179-189 Oct 92. Prepared in cooperation with Environmental Health Research and Testing, Inc., Cincinnati, OH.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Nongenotoxic Environmental Contaminants on Cholesterol and DNA Synthesis in Cultured Primary Rat Hepatocytes.
Category Codes 68G; 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 330925726
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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