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OLS : Record

RECORD NUMBER: 24 OF 674

Main Title Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised).
Author Taubeneck, M. W.; Daston, G. P.; Rogers, J. M.; Keen, C. L.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/400; NIH-HD01743;
Stock Number PB95-126447
Subjects Zinc; Metabolism; Toxicity; Rats; Maternal exposure; Nutrition; Biological effects; Maternal-fetal exchange; Dose-response relationships; Food consumption; Statistical analysis; Urethane; Arsenic; Alcohols; Melphalan; Metallothionein; Reprints; Alpha-hederin; Acute phase response
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB95-126447 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 20p
Abstract The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development.
Supplementary Notes Pub. in Reproductive Toxicology, v8 n1 p25-40 Feb 94. See also AD-A266 504. Prepared in cooperation with California Univ., Davis. and Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs. Sponsored by National Institutes of Health, Bethesda, MD. and Department of Agriculture, Washington, DC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised).
Category Codes 57B; 57Y; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 433519169
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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