OLS : Record


Main Title Ozone Inhibits Prostacyclin Synthesis in Pulmonary Endothelium.
Author Friedman, M.; Madden, M. C.; Saunders, D. S.; Gammon, K.; White, G. C.;
CORP Author North Carolina Univ., Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/423;
Stock Number PB86-231867
Subjects Ozone; Inhibitors; Lung; Reprints; Prostacyclin; Pulmonary endothelium; Air pollution effects
Library   Call Number Additional Info Location Date Modified
NTIS PB86-231867 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 16p
Abstract The effects of ozone on lung arachidonate metabolism in-vitro were studied in cultured bovine pulmonary endothelial cells exposed for 2 hours to ozone in concentrations up to 1.0 ppm. A concentration-dependent decrease in prostacyclin synthesis was found (90% decrease at the highest ozone level of 1.0ppm). The inhibition of prostacyclin synthesis was not due to a decreased release of arachidonic acid from membrane lipids. They also examined the gypoxic pulmonary vasoconstrictive response to 10% oxygen inhalation in anesthetized dogs in-vivo after exposure to 1.0 ppm ozone for 1 hour. Pulmonary vascular resistance was significantly increased after ozone exposure, similar to the findings in dogs given indomethacin (15 mg/kg). The percentage change in the hypoxic pulmonary pressor response was similar between the ozone exposure and indomethacin-treated groups, although due to the variance of the pulmonary vascular resistance values during hypoxia the results did not reach statistical significance. These results suggest that ozone inhalation affects pulmonary endothelial arachidonate metabolism in-vivo as well as in-vitro.
Supplementary Notes Pub. in Prostaglandins, v30 n6 p1069-1083 Dec 85. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Ozone Inhibits Prostacyclin Synthesis in Pulmonary Endothelium.
PUB Date Free Form c1985
Category Codes 6T; 57Y; 68A
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Control Number 628226462
Cataloging Source NTIS/MT
Origin NTIS
Type CAT