||Biochemical Effects of Three Carcinogenic Chlorinated Methances in Rat Liver.
Kitchin, K. T.;
Brown, J. L.;
||Health Effects Research Lab., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Three chlorinated methanes, carbon tetrachloride, chloroform and methylene chloride known to cause liver tumors in rodents, were given by oral gavage to adult female rats both 21 and 4 hours before sacrifice. Then hepatic DNA damage, ornithine decarboxylase, cytochrome P-450, glutathione content and serum alanine aminotransferase activity assays were performed. Carbon tetrachloride increased rat hepatic ornithine decarboxylase activity and decreased cytochrome P-450 content at doses both below and above cytotoxicity (as measured by increased serum alanine aminotransferase activity). At 54 and 160 mg/kg, chloroform increased hepatic ornithine decarboxylase activity with minimal or no elevation in serum alanine aminotransferase activity. After oral administration of 480 mg/kg of chloroform, hepatic ornithine decarboxylase activity, serum alanine aminotransferase activity and hepatic DNA damage were increased while hepatic cytochrome P-450 content was decreased. The results with methylene chloride varied between replicates done on three different days. (Copyright (c) 1989 Alan R. Liss, Inc.)
||Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v9 p61-69, Jan 89.
|NTIS Title Notes
||Reprint: Biochemical Effects of Three Carcinogenic Chlorinated Methances in Rat Liver.
||57Y; 57B; 57F
||PC A02/MF A01