| Main Title |
Biochemical Effects of Three Carcinogenic Chlorinated Methances in Rat Liver. |
| Author |
Kitchin, K. T.;
Brown, J. L.;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/397; |
| Stock Number |
PB90-245978 |
| Subjects |
Toxicology;
Biochemistry;
Liver;
Carbon tetrachloride;
Chloroform;
Chloromethanes;
Glutathione;
Liver neoplasms;
Lethal dosage;
Reprints;
Carcinogenicity tests;
Cell survival;
DNA damage;
Cytochrome P-450;
Ornithine decarboxylase;
Alanine aminotransferase;
Mutagenicity tests
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Date Modified |
| NTIS |
|
PB90-245978 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
12/03/1990 |
|
| Collation |
10p |
| Abstract |
Three chlorinated methanes, carbon tetrachloride, chloroform and methylene chloride known to cause liver tumors in rodents, were given by oral gavage to adult female rats both 21 and 4 hours before sacrifice. Then hepatic DNA damage, ornithine decarboxylase, cytochrome P-450, glutathione content and serum alanine aminotransferase activity assays were performed. Carbon tetrachloride increased rat hepatic ornithine decarboxylase activity and decreased cytochrome P-450 content at doses both below and above cytotoxicity (as measured by increased serum alanine aminotransferase activity). At 54 and 160 mg/kg, chloroform increased hepatic ornithine decarboxylase activity with minimal or no elevation in serum alanine aminotransferase activity. After oral administration of 480 mg/kg of chloroform, hepatic ornithine decarboxylase activity, serum alanine aminotransferase activity and hepatic DNA damage were increased while hepatic cytochrome P-450 content was decreased. The results with methylene chloride varied between replicates done on three different days. (Copyright (c) 1989 Alan R. Liss, Inc.) |
| Supplementary Notes |
Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v9 p61-69, Jan 89. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Biochemical Effects of Three Carcinogenic Chlorinated Methances in Rat Liver. |
| Category Codes |
57Y; 57B; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Control Number |
024228514 |
| Cataloging Source |
NTIS/MT |
| Origin |
NTIS |
| Type |
CAT |
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