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RECORD NUMBER: 40 OF 77

Main Title Identification of Organic N-Chloramines In vitro in Stomach Fluid from the Rat After Chlorination.
Author Scully, F. E.; Mazina, K. E.; Ringhand, H. P.; Chess, E. K.; Campbell., J. A.;
CORP Author Old Dominion Univ., Norfolk, VA. Dept. of Chemical Sciences. ;Battelle Pacific Northwest Labs., Richland, WA. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering.;Health Effects Research Lab., Cincinnati, OH.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/510;
Stock Number PB91-199968
Subjects Chlorination; Stomach contents; Chloramines; Rats; In vitro analysis; Temperature; pH; Isotopes; Amino acids; High performance liquid chromatography; Mass spectrometry; Ions; Reprints;
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB91-199968 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 8p
Abstract When (36)Cl-N-cholorpiperidine (NCP) (300 mg/L as Cl2) was mixed with stomach fluid from laboratory rats (fasted either 24 or 48 hr) and incubated in the dark for 30 min at 37 C and at higher pH values, approximately one-third was reduced to chloride and between 7% and 63% of the radiolabel was found to chromatograph in a manner distinctly different from (36)Cl-chloride of (36)Cl-NCP. The new fraction is referred to as the (36) Cl-chloroorganic fraction. The remainder of the radiolabel was associated with (36)Cl-NCP. Varying concentrations of (36)Cl-NCP (3-200 mg/L as Cl2) have been incubated for 30 min at 37 C with stomach fluid at varying pH on the product distribution. At low pH values a threshold concentration of approximately 100 mg/L active chlorine was measured below which all chloramine was reduced to (36)Cl-chloride. As the pH and concentration of (36)Cl-NCP were increased, the percentage of chloramine reduced to chloride decreased. Using concentrations between 110 and 120 mg/L (Cl2) 7% and 4% of the label was associated with the (36)Cl-chloroorganic fraction at pH 7.1 and at pH 2.2, respectively.
Supplementary Notes Pub. in Chemical Research in Toxicology, v3 n4 p301-306 Jul 90. Presented at International Symposium on Health Effects of Drinking Water Disinfectants and Disinfection By-Products (2nd), Cincinnati, OH., August 27-29, 1985. Prepared in cooperation with Battelle Pacific Northwest Labs., Richland, WA., and North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering.
NTIS Title Notes Journal article.
Title Annotations Reprint: Identification of Organic N-Chloramines In vitro in Stomach Fluid from the Rat After Chlorination.
Category Codes 57B
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 122130871
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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