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RECORD NUMBER: 8 OF 13

Main Title Immunosuppression of Pulmonary Natural Killer Activity by Exposure to Ozone.
Author Burleson, G. R.; Keyes, L. L.; Stutzman., J. D.;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/393;
Stock Number PB90-246018
Subjects Ozone; Toxicology; Immunology; Exposure; Rats; Reprints; Natural killer cells; Pulmonary function tests; Air pollution effects(Animals); Immunologic cytotoxicity; Dose-response relationships; Disease susceptibility
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB90-246018 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/03/1990
Collation 22p
Abstract Ozone is an oxidant gas and an ubiquitous oxidant air pollutant with the potential to adversely affect pulmonary immune function with a subsequent increase in disease susceptibility. Pulmonary natural killer (NK) activity was measured in order to assess the pulmonary immunotoxicity of continuous ozone exposure. Continuous ozone exposures at 1.0 ppm were performed for 23.5 hours per day for either 1, 5, 7, or 10 consecutive days. Pulmonary immune function was assessed by measuring NK activity from whole-lung homogenate of male Fischer-344 rats. Results of the study indicated that continuous ozone exposure for 1, 5, or 7 days resulted in a significant decrease in pulmonary NK activity. This suppressed pulmonary NK activity returned to control levels after continuous exposure to ozone for 10 days. This adaption, or attenuation process, is complex and poorly understood. Pulmonary NK activity was also suppressed at 0.5 ppm ozone, but not at 0.1 ppm ozone, for 23.5 hours. NK activity is important for defense against viral, bacterial, and neoplastic disease. (Copyright (c) 1989 by Marcel Dekker, Inc.)
Supplementary Notes Pub. in Immunopharmacology and Immunotoxicology, v11 n4 p715-735 Dec 89. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Immunosuppression of Pulmonary Natural Killer Activity by Exposure to Ozone.
Category Codes 68G; 57Y; 57J; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 024228550
Cataloging Source NTIS/MT
Origin NTIS
Type CAT


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