Record Display for the EPA National Library Catalog
RECORD NUMBER: 88 OF 252Main Title | Initial Submission: Letter from Hoechst Celanese Corp Submitting Information on an Oral Study of the Embryotoxic Effect with a Formulation of Glufosinate Nh4 in Wistar Rats. | |||||||||||
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CORP Author | Hoechst Celanese Corp., Summit, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
Year Published | 1992 | |||||||||||
Report Number | 88-920006596 | |||||||||||
Stock Number | OTS0545195 | |||||||||||
Additional Subjects | Toxicology ; Health effects ; Glufosinate Nh4 ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 77182-82-2 | |||||||||||
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Collation | 7p | |||||||||||
Abstract | Glufosinate ammonium (77182-82-2) was evaluated for developmental toxicity. Twenty pregnant Wistar rats per group were administered the test material by oral gavage at 0, 10, 50, or 250 mg/kg/day on days 7- 16 of gestation. Dose-dependent maternal toxicity was observed at all treatment levels including motorial unrest, hyperactivity (50-150 mg/kg/day), drowsiness, vaginal hemorrhages, weight loss, and at 250 mg/kg/day only, intrauterine death and one mortality. Ureter and kidney dilation were observed in fetuses of all treatment groups. A slight retardation of skeletal ossification was observed at 250 mg/kg/day. This study was briefly summarized. No further information was reported. |