Main Title |
Effects of endogenous ammonia on neutralization of inhaled sulfuric acid aerosols / |
Author |
Loscutoff, Susan M.,
|
CORP Author |
Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Cincinnati, OH. |
Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Available to the public through the National Technical Information Service. |
Year Published |
1979 |
Report Number |
EPA-600/1-79-045; EPA-68-03-2665 |
Stock Number |
PB80-147978 |
OCLC Number |
06368204 |
Subjects |
Sulfuric acid--Toxicology ;
Ammonia ;
Aerosols ;
Inhalation ;
Gases, Asphyxiating and poisonous ;
Sulfuric Acids ;
Sulphuric acid--Toxicology
|
Additional Subjects |
Sulfuric acid ;
Ammonia ;
Toxicology ;
Sulfates ;
Dogs ;
Respiration ;
Exposure ;
Laboratory animals ;
Concentration(Composition) ;
Aerosols ;
Lung ;
Toxic substances ;
Environmental health
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-79-045 |
|
Headquarters Library/Washington,DC |
04/23/2014 |
EKBD |
EPA 600/1-79-045 |
|
Research Triangle Park Library/RTP, NC |
04/17/2019 |
ELBD ARCHIVE |
EPA 600-1-79-045 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
NTIS |
PB80-147978 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
x, 38 pages : illustrations. |
Abstract |
Nine male beagle dogs were exposed by inhalation to 0, 6 and 10.5 mg/cu.m sulfuric acid aerosols with normal ammonia, increased blood ammonia, and increased inhaled ammonia to determine whether the addition of ammonia affected the toxicity of sulfuric acid aerosols. Exhaled concentration of ammonia, sulfuric acid and ammonium bisulfate were measured to determine the neutralization of inhaled aerosol by ammonia in the lung. Unneutralized sulfuric acid aerosol was detected in exhaled air only during exposure to 10.5 mg/cu.m H2SO4 with approximately 25 percent of the total exhaled sulfate measured as H2SO4. No unneutralized H2SO4 was measured after a tenfold increase in blood ammonia by ammonium acetate infusion. Increased blood ammonia resulted in a slightly decreased irritant effect of 10.5 mg/cu.m H2SO4 in the lung using residual volume and functional residual capacity as endpoints. The results indicate that neutralization of inhaled sulfuric acid aerosols can be increased by increasing blood ammonia concentrations. However, the increased neutralization does not seem to markedly affect the toxicity of the inhaled and aerosols. |
Notes |
"Biology Department, Battelle Memorial Institute, Pacific Northwest Laboratories." Dec. 1979. Includes bibliographical references (pages 36-37). "Contract No. 68-03-2665." |