Record Display : EPA National Library Catalog

RECORD NUMBER: 20 OF 1179

Main Title Acrylamide: a Two-year Drinking Water Chronic Toxicity-oncogenicity Study in Fischer 344 Rats Final Report Sponsored by Amer Cyanamid, dow Chem Usa, Nalco Chem.
CORP Author Dow Chemical Co., Midland, MI. Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8431151
Stock Number OTS0507273
Additional Subjects Toxicology; Health effects; Acrylamide; Chronic Toxicity; Combined Chronic Toxicity/carcinogenicity; Mammals; Rats; Oral; Diet; Biochemistry; Toxic substances; Laboratory animals; CAS No 79-06-1
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NTIS OTS0507273 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 48p
Abstract
Acrylamide was tested for chronic toxicity and oncogenicity in Fischer 344 rats (90/sex/dose level) fed nominal doses of 0, 0.01, 0.1, 0.5, or 2.0 mg/kg bw/day in the drinking water for 2 years. In groups given 2.0 mg/kg/day, there was significantly increased mortality (beginning about the 21st month) and degeneration of the peripheral nerves. In females given 2.0 mg/kg/day, tibial nerve degeneration was observed. Other parameters of food and water consumption, clinical chemistry, organ weights, and organ/body weight ratios were not consistently affected by the treatment. A significantly increased tumor incidence at the 2.0 mg/kg/day dose level was reported for the following sites: females; mammary gland (benign and malignant), pituitary gland, central nervous system (malignant), clitoral gland (benign), uterus (malignant), and the oral cavity (benign); males and females; the thyroid gland (malignant and benign). The incidence of scrotal mesothelioma (malignant) was also significantly increased in male rats given 0.5 mg/kg/day.