| Main Title |
Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised). |
| Author |
Taubeneck, M. W.;
Daston, G. P.;
Rogers, J. M.;
Keen, C. L.;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/400; NIH-HD01743; |
| Stock Number |
PB95-126447 |
| Additional Subjects |
Zinc;
Metabolism;
Toxicity;
Rats;
Maternal exposure;
Nutrition;
Biological effects;
Maternal-fetal exchange;
Dose-response relationships;
Food consumption;
Statistical analysis;
Urethane;
Arsenic;
Alcohols;
Melphalan;
Metallothionein;
Reprints;
Alpha-hederin;
Acute phase response
|
| Holdings |
| Library |
|
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
|
PB95-126447 |
Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. |
NTIS |
03/06/1995 |
|
| Collation |
20p |
| Abstract |
The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development. |
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