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Main Title Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised).
Author Taubeneck, M. W.; Daston, G. P.; Rogers, J. M.; Keen, C. L.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/400; NIH-HD01743;
Stock Number PB95-126447
Additional Subjects Zinc; Metabolism; Toxicity; Rats; Maternal exposure; Nutrition; Biological effects; Maternal-fetal exchange; Dose-response relationships; Food consumption; Statistical analysis; Urethane; Arsenic; Alcohols; Melphalan; Metallothionein; Reprints; Alpha-hederin; Acute phase response
Library   Call Number Additional Info Location Last
NTIS PB95-126447 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 20p
The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development.