This document is one of a series of four technical guidance documents intended to provide information and possible approaches for addressing various aspects of permitting and operating a UIC Class VI injection well. There are three companion draft guidance documents that focus on site characterization, well construction, and testing and monitoring: (1) Geologic Sequestration of Carbon Dioxide: Draft Underground Injection Control (UIC) Program Class VI Well Site Characterization Guidance for Owners and Operators. (2) Geologic Sequestration of Carbon Dioxide: Draft Underground Injection Control (UIC) Program Class VI Well Construction Guidance for Owners and Operators. (3) Geologic Sequestration of Carbon Dioxide: Draft Underground Injection Control (UIC). Program Class VI Well Testing and Monitoring Guidance for Owners and Operators (this guidance is under development and will be available in the near future). These draft guidance documents are intended to complement each other and to assist owners and operators in preparing permit applications that satisfy the requirements of the GS Rule. Class VI injection well regulations are tailored to the characteristics of individual sites. For example, the required site characterization data collected will inform the model development for AoR delineation, and AoR models will be reevaluated, and perhaps change, based on the results of site testing and monitoring data. Cross-linkages between guidance documents are noted in the text where appropriate. Additional guidance on developing, presenting, and using the required Class VI project plan information as part of a Class VI injection well permit application is provided in the draft project plan development guidance: Geologic Sequestration of Carbon Dioxide: Draft Underground Injection Control (UIC) Program Class VI Well Project Plan Development Guidance for Owners and Operators.