Record Display for the EPA National Library Catalog
RECORD NUMBER: 356 OF 397| Main Title | Teratogenic Evaluation of Ethylene Chlorhydrin (ECh, 2-Chlorethanol) in Mice. | |||||||||||
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| Author | Courtney, K. Diane ; Andrews, James E. ; Grady, Margaret ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Year Published | 1982 | |||||||||||
| Report Number | EPA-600/J-82-122; | |||||||||||
| Stock Number | PB82-247164 | |||||||||||
| Additional Subjects | Evaluations ; Mice ; Laboratory animals ; Ingestion(Biology) ; Dosage ; Chlorine organic compounds ; Environmental surveys ; Reprints ; Ethanol/chloro ; Teratogenesis | |||||||||||
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| Collation | 13p | |||||||||||
| Abstract | ECh administered intragastrically to pregnant CD-1 mice from the 6th to the 16th day of gestation at a dose of 100 mg/kg produced a significant reduction in maternal weight gain and a decrease in fetal body weight and liver weight. A lower dose of 50 mg/kg had no consistent effect and a higher dose of 150 mg/kg was maternally lethal. Administration of ECh in the drinking water at doses of 16, 43, 77, or 227 mg/kg did not produce any adverse effects on maternal or fetal body weight, viability, or fetal development. |