Record Display for the EPA National Library Catalog

RECORD NUMBER: 48 OF 227

Main Title Critical Issues in Intra- and Interspecies Dosimetry of Ozone.
Author Miller, F. J. ; Overton, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/359;
Stock Number PB90-216003
Additional Subjects Ozone ; Dosimetry ; Air pollution ; Laboratory animals ; Exposure ; Humans ; Risk ; Mathematical models ; Comparison ; Absorption ; Respiration ; Age ; Tolerances(Physiology) ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-216003 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract
Knowledge of dose at the target site is a fundamental starting point in making interspecies dosimetric comparisons. To the extent that information is available on the effective dose of a compound, the confidence in risk assessments is increased. To facilitate judgments about effects determined in animals relative to likelihood of risk associated with human exposure to ozone (O3), a mathematical dosimetry model has been developed for interspecies comparisons. The model incorporates the major factors affecting the absorption of O3 in the respiratory tract: the morphology of the respiratory tract, the route, depth and rate of breathing, physicochemical properties of O3, the physical and chemical processes which govern gas transport, and the physicochemical properties of the lining fluids and tissue material of the airways and gas exchange units. Also discussed are the application of the dosimetry model for examining age-dependent susceptibility to O3 and the potential usefulness of such models for relating microdosimetry to microtoxicology.