Record Display for the EPA National Library Catalog

RECORD NUMBER: 21 OF 227

Main Title Applications of an Exact NOAEL (No-Observed-Adverse-Effect-Level) Procedure for Dichotomous Data from Animal Experiments.
CORP Author Brown (Kenneth G.), Chapel Hill, NC.;Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher Nov 89
Year Published 1989
Report Number EPA-68-01-6826; EPA/600/8-89/068;
Stock Number PB90-145780
Additional Subjects Mathematical models ; Toxicity ; Dosimetry ; Graphs(Charts) ; Exposure ; Animals ; No-observed-adverse-effects-level ; Dose-response relationships ; Risk assessment ; False negative reactions
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-145780 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 49p
Abstract
A statistical method has been developed that utilizes a step-wise hypothesis testing procedure to estimate the distribution of the no-observed-adverse-effect level (NOAEL), and thereby to estimate the expected value of the NOAEL and its variability. The methodology is dependent upon the sum of the dose group sizes, the expected response rates, experimental dose levels, and the type I error rates. The technique may be employed to evaluate the reliability of the NOAEL and to provide a measure of its variability.