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Grantee Research Project Results

Grantee Research Project Results

Publications Details for:

Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
Grant Number R831709C001
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)


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Abstract (11)
Book Chapter (1)
Journal Article (16)
Presentation (6)
Reference Type Citation Progress Report Year Document Sources
Abstract Faustman EM, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. The Toxicologist 2005;84(S1):1655.
R831709C001 (2005)
not available
Abstract Faustman EM, Griffith WC, Vigoren E. Lessons learned from longitudinal studies to identify high exposure groups using OP pesticide urinary biomarkers. Toxicology Letters 2006;164(Suppl 1):S161.
abstract available     full text available
R831709 (2005)
R831709 (2007)
R831709C001 (2007)
Abstract Giordano G, Afsharinejad Z, Kavanagh T, Costa L. Reactive oxygen species mediate the neurotoxicity induced by organophosphorus insecticides in mouse cerebellar granule cells. The Toxicologist 2006;90(1):301.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2006)
R831709C001 (2007)
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Abstract Gohlke JM, Griffith WC, Faustman EM. Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. The Toxicologist 2005;84(S1):69.
R831709C001 (2005)
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Abstract Gribble EJ, Yu X, Hong S, Faustman EM. A role for p53 in mouse midbrain neural precursor cell (NPC) cell cycle arrest and premature neuronal differentiation following methylmercury exposure. The Toxicologist 2006;90:366.
R831709 (2005)
R831709 (2006)
R831709C001 (2006)
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Abstract Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. The Toxicologist 2005;84(S1):2257.
R831709C001 (2005)
not available
Abstract Robinson J, Yu X, Hong S, Kim E, Sullivan R, Griffith W, Faustman E. Differential impact of cadmium on gene expression during neuralation in the C57BL/6 and SWV. Birth Defects Research Part A 2006;76(5):392.
R831709 (2005)
R831709 (2006)
R831709C001 (2006)
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Abstract Robinson JF, Yu X, Gribble EJ, Hong S, Kim E, Sidhu JS, Faustman EM. Examination of arsenic-induced alterations in cell cycle progression and global gene expression in p53 transgenic mouse embryonic fibroblasts. The Toxicologist 2006;90:91-92.
R831709 (2005)
R831709 (2006)
R831709C001 (2006)
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Abstract Yu X, Sidhu J, Robinson J, Hong S, Faustman EM. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. The Toxicologist 2005;84(S1):1155.
R831709C001 (2005)
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Abstract Yu X, Griffith W, Hanspers K, Robinson J, Faustman EM. Functional interpretation of dose-and time-dependent microarray data: quantitative integration of GO ontology analysis for toxicology and risk assessment. The Toxicologist 2006;90(1):182-183.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2006)
R831709C001 (2007)
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Abstract Yu X, Griffith WC, Hanspers K, Ong H, Faustman EM. A system based approach to identify potential signalling pathways during gonad development from microarray data. Birth Defects Research Part A 2006;76(5):339.
R831709 (2005)
R831709 (2006)
R831709C001 (2006)
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Book Chapter Faustman EM, Gohlke JM, Ponce RA, Lewandowski TA, Seeley MR, Whittaker SG, Griffith WC. Experimental approaches to evaluate mechanisms of developmental toxicity. In: Hood RD, ed. Developmental and Reproductive Toxicology: A Practical Approach. Boca Raton, FL: CRC Press, Inc., 2004, pp. 10-44.
R831709 (2005)
R831709 (2007)
R831709C001 (2004)
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Journal Article Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicological Sciences 2004;78(1):125-134.
abstract available    
R831709 (2007)
R831709C001 (2004)
Journal Article Costa LG. Current issues in organophosphate toxicology. Clinica Chimica Acta 2006;366(1-2):1-13.
abstract available    
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2006)
Journal Article Costa LG, Cole TB, Furlong CE. Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. LabMedicine 2006;37(2):109-113.
abstract available     full text available
R831709 (2005)
R831709 (2007)
R831709C001 (2007)
R831709C002 (2007)
Journal Article Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249.
abstract available     full text available
R831709 (2005)
R831709 (2007)
R831709C001 (2007)
R831709C002 (2007)
Journal Article Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W, McLaughlin TJ. A framework for assessing risks to children from exposure to environmental agents. Environmental Health Perspectives 2004;112(2):238-256.
abstract available    
R831709 (2007)
R831709C001 (2004)
Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429.
abstract available     full text available
R827027 (2002)
R829389 (2003)
R829389 (2004)
R829389 (2005)
R829389 (Final)
R829390 (2005)
R829390 (Final)
R829390C002 (2005)
R831709 (2005)
R831709C001 (2004)
R831710 (2005)
R831710 (Final)
R831710C001 (2006)
R831710C002 (2006)
R831711 (2005)
R831711 (2006)
R831711 (2007)
R831711 (Final)
R831711C001 (2006)
R831711C002 (2004)
R831711C002 (2006)
R831711C003 (2006)
R832141 (2005)
R832141 (2007)
R832141 (Final)
Journal Article Faustman EM, Gohlke J, Judd NL, Lewandowski TA, Bartell SM, Griffith WC. Modeling developmental processes in animals: applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology 2005;19(3):615-624.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2004)
R831709C001 (2005)
R831709C001 (2006)
Journal Article Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2006)
R831709C001 (2007)
R831709C002 (2007)
Journal Article Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse. Developmental Brain Research 2004;151(1-2):43-54.
abstract available     full text available
R831709 (2005)
R831709 (2007)
R831709C001 (2004)
Journal Article Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicological Sciences 2005;86(2):470-484.
abstract available     full text available
R831709 (2004)
R831709 (2005)
R831709 (2007)
R831709C001 (2005)
Journal Article Gribble EJ, Hong SW, Faustman EM. The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53-dependent. Birth Defects Research Part A: Clinical and Molecular Teratology 2005;73(1):29-38.
abstract available    
R831709 (2005)
R831709 (2007)
R831709C001 (2004)
Journal Article Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2005)
R831709C001 (2006)
R831709C002 (2006)
Journal Article Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. Developmental Brain Research 2003;141(1-2):117-128.
abstract available     full text available
R831709 (2005)
R831709 (2007)
R831709C001 (2004)
Journal Article Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis:potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133.
abstract available     full text available
R831709 (2005)
R831709 (2007)
R831709C001 (2004)
Journal Article Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006;89(2):475-484.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2005)
R831709C001 (2006)
R832733 (Final)
Journal Article Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose-and time-dependent microarray data:quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006;92(2):560-577.
abstract available     full text available
R831709 (2005)
R831709 (2006)
R831709 (2007)
R831709C001 (2006)
R832733 (2007)
R832733 (Final)
Presentation Faustman EM, Yu X, Sidhu JS, Hong S, et al. Integration of toxicogenomic and knowledge-based pathway mapping for elucidating shared molecular mechanisms of metal toxicity. Poster presented at the 10th International Congress of Toxicology, Tampere, Finland, July 11-15, 2004.
R831709C001 (2005)
not available
Presentation Faustman EM, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005.
R831709C001 (2005)
not available
Presentation Gohlke JM, Griffith WC, Faustman EM. Computational model for dose-response comparisons of two mechanistic hypotheses for ethanol-induced neurodevelopmental toxicity. Presented at the Society for Risk Analysis 2004 Annual Meeting, Palm Springs, CA, December 5-8, 2004.
R831709C001 (2005)
not available
Presentation Gohlke JM, Griffith WC, Faustman EM. Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005.
R831709C001 (2005)
not available
Presentation Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005.
R831709C001 (2005)
not available
Presentation Yu X, Sidhu J, Robinson J, Hong S, Faustman EM. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005.
R831709C001 (2005)
not available

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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