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Grantee Research Project Results

Grantee Research Project Results

Publications Details for:

Development of a BBPK Model for the Thyroid Axis in the Pregnant Rat and Fetus for the Dose Response Analysis of Developmental Neurotoxicity
Grant Number R832134
RFA: Development and Characterization of Biological Systems for Studying Low Dose Effects of Endocrine Disrupting Chemicals (2004)


Other views: Selected publication types Journal articles Publications submitted after final report Redisplay this page with Reference Title, Journal, and Author Columns Display this page in RIS format

Abstract (6)
Journal Article (5)
Presentation (4)
Reference Type Citation Progress Report Year Document Sources
Abstract Crofton K, Fisher J, Zoeller R, Blount B, Hedge J, Anderson W, Gilbert M. Iodide deficiency: metabolic and hormonal studies for PBPK modeling. The Toxicologist 2009;108(1):32. R832134 (2008)
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Abstract Fatuyi BO, Mumtaz M, Fisher JW. Environmental exposures to thyroid disrupting chemicals: key considerations for developing a BBDR-HPT axis model for the pregnant mother and fetus. The Toxicologist 2009;108(1):95. R832134 (2008)
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Abstract Gilbert ME, Hedge J, Grant K, Lyke D, Gitata I, Anderson W, Fisher J, Zoeller RT, Crofton KM. Iodide deficiency, thyroid hormones, and neurodevelopment. The Toxicologist 2009;108(1):32. R832134 (2008)
not available
Abstract McLanahan ED, Andersen ME, Mumtaz M, Fisher JW. BBPK model of the hypothalamic-pituitary-thyroid axis in adult male rats. The Toxicologist 2007;96(1):394. R832134 (2007)
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Abstract Myers L, McLanahan ED, Fisher JW, Andersen M. Development of BBPK radiolabeled sub-models for the HPT axis in PND 14 SD rat pups. The Toxicologist 2007;96(1):395. R832134 (2007)
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Abstract Taylor MA, Stramiello M, Paolino N, Jennings N, Swant J, Fisher J, Wagner J, Gilbert M, Ferguson D. Brain, liver, and thyroid biomarkers reflect enhanced sensitivity of the developing rat to thyroid hormone depletion. The Toxicologist 2007;96(1):140. R832134 (2007)
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Journal Article Fisher JW, Campbell J, Muralidhara S, Bruckner JV, Ferguson D, Mumtaz M, Harmon B, Hedge JM, Crofton KM, Kim H, Almekinder TL. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Toxicological Sciences 2006;90(1):87-95 R832134 (2008)
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Journal Article McLanahan ED, Campbell JL, Ferguson DC, Harmon B, Hedge JM, Crofton KM, Mattie DR, Braverman L, Keys DA, Mumtaz M, Fisher JW. Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126. Toxicological Sciences 2007;97(2):308-317 R832134 (2008)
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Journal Article McLanahan ED, Andersen ME, Fisher JW. A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat:evaluation of iodide deficiency. Toxicological Sciences 2008;102(2):241-253. R832134 (2007)
R832134 (2008)
Journal Article McLanahan ED, Andersen ME, Campbell Jr. JL, Fisher JW. Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH. Environmental Health Perspectives 2009;117(5):731-738. R832134 (2008)
Journal Article Taylor MA, Swant J, Wagner JJ, Fisher JW, Ferguson DC. Lower thyroid compensatory reserve of rat pups after maternal hypothyroidism: correlation of thyroid, hepatic, and cerebrocortical biomarkers with hippocampal neurophysiology. Endocrinology 2008;149(7):3521-3530. R832134 (2007)
R832134 (2008)
Presentation Ferguson D. A Primer of Comparative Thyroidology: Relevance to Methods and Models. Presented at the Workshop at SOT, Thyroid Hormone Disruption: From Kinetics to Dynamics, Charlotte, NC, March 26, 2007 (Invited Speaker). R832134 (2007)
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Presentation Fisher JW, Ferguson D. Development of a BBPK Model for the Thyroid Axis in the Pregnant Rat and Fetus for the Dose Response Analysis of Developmental Neurotoxicity. Presented at the U.S. EPA Endocrine Disruptors Program STAR Progress Review Workshop, July 2006. R832134 (2006)
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Presentation Fisher J. Pharmacokinetic modeling of the thyroid axis. Presented at the National Academies Workshop on Risk Assessment Considerations for Interpretation of Data from Bioassays for Thyroid Activity and from Human Biomonitoring Data, Washington, DC, May 14-15, 2008 (invited). R832134 (2008)
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Presentation Fisher J. PBPK and Biologically Based Computational Models for Thyroid Active Chemicals and the Hypothalamic-Pituitary-Thyroid Axis to Evaluate Developmental Neurotoxicity. Presented at the Workshop at SOT, Thyroid Hormone Disruption: From Kinetics to Dynamics, Charlotte, NC, March 26, 2007 (Invited Speaker and Session Co-Chair). R832134 (2007)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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