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Publications Details for:

Chemical Induced Changes in Gene Expression Patterns Along the HPG-axis at Different Organizational Levels Using a Small Animal Model (Japanese medaka)
Grant Number R831846
RFA: Computational Toxicology and Endocrine Disruptors: Use of Systems Biology in Hazard Identification and Risk Assessment (2004)


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Journal Article (3)
Presentation (26)
Reference Type Citation Progress Report Year Document Sources
Journal Article Park JW, Tompsett AR, Zhang X, Newsted JL, Jones PD, Au DW, Kong R, Wu RS, Giesy JP, Hecker M. Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds. Environmental Toxicology and Chemistry 2009;28(9):1951-1962. R831846 (Final)
Journal Article Tompsett AR, Park JW, Zhang X, Jones PD, Newsted JL, Au DWT, Chen EXH, Yu R, Wu RSS, Kong RYC, Giesy JP, Hecker M. In situ hybridization to detect spatial gene expression in medaka. Ecotoxicology and Environmental Safety 2009;72(4):1257-1264. R831846 (Final)
Journal Article Zhang X, Hecker M, Park JW, Tompsett AR, Newsted J, Nakayama K, Jones PD, Au D, Kong R, Wu RS, Giesy JP. Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka. Aquatic Toxicology 2008;88(3):173-182. R831846 (Final)
Presentation S.J. Coefield, M.J. Zwiernik, R.M. Seston, T.B. Fredricks, J.N. Moore, D. Tazelaar, D.L. Kay, P.D. Jones, P. Bradley and J.P. Giesy. PCDDs and PCDFs in Small Mammals Foraging in the Tittabawassee River Floodplain, Michigan. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation T.B. Fredricks, M.J. Zwiernik, S.J. Coefield, R.M. Seston, J.N. Moore, D.L. Tazelaar, T.C. White, D.P. Kay and J.P. Giesy. Site-specific Dietary Exposure Assessment of Several Passerine Bird Species to PCDDs and PCDFs. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation J.P. Giesy, M.H. Depledge, P.K.S. Lam and R.S.S. Wu. Monitoring of Exposure to and Potential Effects of Contaminants in the Environment. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD R831846 (2005)
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Presentation T. Gracia, P.D. Jones, K. Hilscherova, K. Higley, J.L. Newsted and J.P. Giesy. Effects of Pharmaceuticals on Gene Expression and Hormone Production in H295R Cell Line Using Q-RT-PCR/ELISA. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Hecker M, Tompsett AR, Park JW, Jones PD, Newsted JL, Giesy JP. Chemical induced changes in gene expression patterns along the HPG-axis at different organizational levels using a small animal model (Japanese medaka). Presented at the Computational Toxicology Workshop, June 2006. R831846 (2006)
R831846 (Final)
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Presentation K. Kannan, B. Johnson, S.S. Yohn, J.P. Giesy and D.T. Long. Spatial and Temporal Distributions of Polycyclic Aromatic Hydrocarbons in Sediments from Michigan Inland Lakes. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation D.P. Kay, A.L. Blankenship, M.J. Zwiernik, P.D. Jones, J.L. Newsted and J.P. Giesy. PCDDs and PCDFs in Aquatic and Terrestrial Food Webs of the Tittabawasee River, Michigan. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation J.-S. Khim, D.L. Villeneuve, K. Kannan B. Johnson, J.P. Giesy and C. Koh. Characterization and Distribution of Dioxin-like and Estrogenic Compounds in Sediment from Korean Coasts. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation J.-S. Khim, D.L. Villeneuve, K. Kannan, J.P. Giesy and C. Koh. Dioxin-like and Estrogenic Compounds and Activities Associated With Marine Sediment from Yeongil Bay, Korea. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation J.-S. Khim, D. Villeneuve, K. Kannan, J.P. Giesy and C. Koh. Distribution and Sources of Trace Organic Contaminants in Marine Sediment. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation J.N. Moore, C.S. Park, M.J. Zwiernik, D.P. Kay, D.L. Tazelaar, D.W. Hamman and J.P. Giesy. Tissue Residue Concentrations of PCDDs and PCDFs in Megaloptera: A comparison to Other Benthic Invertebrate Orders. To: 26th Annual Meeting, November 13-17, 2005, Baltimore, MD. R831846 (2005)
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Presentation J.L Newsted, P.D. Jones, K. Coady and J.P. Giesy. Avian Toxicity Reference Values (TRVs) for Perfluorooctane Sulfonate (PFOS). To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Park JW, Tompsett AR, Hecker M, Newsted JL, Jones PD, Giesy JP. Application of in situ hybridization to detect CYP19-A1 and-A2 aromatase gene expression patterns along the HPG-axis at different organizational levels in Japanese medaka (Oryzias latipes). Presented at the 26th Annual Society of Environmental Toxicology and Chemistry (SETAC) Meeting, Baltimore MD, November 13-17, 2005. R831846 (2005)
R831846 (2006)
R831846 (Final)
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Presentation Park JW, Tompsett AR, Hecker M, Jones PD, Newsted JL, Giesy JP. mRNA gene expressions of CYP19a and b in juvenile Japanese medaka (Oryzias latipes) exposed to fadrozole:comparison of RT-PCR with ISH methods. Presented at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC) North America, Montreal, Quebec, November 4-9, 2006. R831846 (Final)
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Presentation Park JW, Tompsett AR, Zhang X, Hecker M, Jones PD, Newsted JL, Giesy JP. Development of fluorescence in situ hybridization techniques to detect and quantify expression profiles of genes along the HPG-axis in Japanese medaka. Presented at the 28th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Milwaukee, WI, November 11-15, 2007. R831846 (Final)
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Presentation R.M. Seston, M.J. Zwiernik, J.N. Moore, D.L. Tazelaar, H.L. Wong, P.W. Bradley, T.B. Fredricks, J.J. Coefield, P.D. Jones and J.P. Giesy. Assessment of Belted Kingfisher (Ceryle alcyon) Dietary Exposure to PCDDs and PCDFs in the Tittabawassee River, MI. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation D.L. Tazelaar, D.P. Kay, M.J. Zwiernik, J.N. Moore, D.W. Hamman, A.L. Blankenship, T.B. Fredricks, R.M. Seston, S.J. Coefield and J.P. Giesy. A Comparison of PCDD and PCDF Bioavailability Among Terrestrial Invertebrates from the Tittabawassee River Floodplain. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Tompsett AR, Park JW, Hecker M, Jones PD, Newsted JL, Giesy JP. Chemical induced changes in gene expression patterns along the HPG-axis at different organizational levels using a small animal model (Japanese medaka). Presented at the Science To Achieve Results (STAR) Computational Toxicology Progress Review Workshop, Research Triangle Park, NC, July 18-19, 2005. R831846 (2005)
R831846 (2006)
R831846 (Final)
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Presentation Tompsett AR, Park JW, Hecker M, Newsted JL, Jones PD, Giesy JP. Application of in situ hybridization techniques to detect CYP19-A1 and-A2 aromatase gene expression patterns along the HPG-axis in Japanese medaka (Oryzias latipes). Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Ohio Valley Chapter Meeting, Fort Wayne, IN, April 20-21, 2006. R831846 (2006)
R831846 (Final)
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Presentation Tompsett AR, Park JW, Hecker M, Jones PD, Newsted JL, Giesy JP. Elucidating changes in aromatase (CYP19) gene expression using in situ hybridization techniques in a whole animal model. Presented at the 27th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Montreal, Quebec, November 4-9, 2006. R831846 (Final)
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Presentation Tompsett AR, Park JW, Zhang X, Hecker M, Jones PD, Newsted JL, Au DWT, Giesy JP. Gene expression and histological structure as biomarkers of chemical exposure in Japanese medaka. Presented at the 28th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Milwaukee, WI, November 11-15, 2007. R831846 (Final)
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Presentation H. Yoo, P.D. Jones, P.W. Bradley, M. Gužviae, B.L. Upham, J.E. Trosko, J.L. Newsted and J.P. Giesy. Separation and Characterization pf Structural Isomers of Perfluorinated Compounds. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation X. Zhang, R.M.K. Yu, P.D Jones, J.L. Newsted, T. Gracia, M. Hecker, R.S.S Wu and J.P. Giesy. A Comparison of H295R, R2C and JEG-3 Cells as Screening Tools for Effects on Steroidogenesis. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Zhang X, Park J-W, Tompsett AR, Hecker M, Jones PD, Newsted J, Giesy JP. Development and validation of a quantitative real time RT-PCR system to study chemical induced effects on the HPG-axis of Medaka (Oryzias latipes). Presented at the 27th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Montreal, Quebec, November 4-9, 2006. R831846 (Final)
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Presentation Zhang X, Tompsett AR, Park J-W, Hecker M, Newsted JL, Jones PD, Giesy JP. Testing of five model endocrine disrupting chemicals using Medaka brain-pituitary-gonadal (BHG) axis model and RT-PCR array method. Presented at the 28th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Milwaukee, WI, November 11-15, 2007. R831846 (Final)
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Presentation M. Zwiernik, J. Moore, D. Tazelaar, D. P. Kay, D. Hamman, A. Blankenship and J.P. Giesy. Mink and PCDD/DFs in the Tittabawasee River. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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