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Grantee Research Project Results

Publications Details for:

Systems Biology Modeling of Fathead Minnow Response to Endocrine Disruptors
Grant Number R831848
RFA: Computational Toxicology and Endocrine Disruptors: Use of Systems Biology in Hazard Identification and Risk Assessment (2004)


Other views: Selected publication types Journal articles Publications submitted after final report Redisplay this page with Reference Title, Journal, and Author Columns Display this page in RIS format

Book Chapter (1)
Journal Article (6)
Presentation (16)
Reference Type Citation Progress Report Year Document Sources
Book Chapter Denslow ND, Knoebl I, Larkin P. Approaches in proteomics and genomics for eco-toxicology. In: Moon TW, Mommsen TP, eds. Environmental Toxicology. Biochemistry and Molecular Biology of Fishes Volume 6. San Diego, CA: Elsevier, 2005, Chapter 3, pp. 85-118. R831848 (2006)
Journal Article Hemming JM, Allen HJ, Thuesen KA, Turner PK, Waller WT, Lazorchak JM, Lattier D, Chow M, Denslow N, Venables B. Temporal and spatial variability in the estrogenicity of a municipal wastewater effluent. Ecotoxicology and Environmental Safety 2004;57(3):303-310. R831848 (2006)
Journal Article Knoebl I, Hemmer MJ, Denslow ND. Induction of zona radiata and vitellogenin genes in estradiol and nonylphenol exposed male sheepshead minnows (Cyprinodon variegatus). Marine Environmental Research 2004;58(2-5):547-551. R831848 (2006)
Journal Article Knoebl I, Blum JL, Hemmer MJ, Denslow ND. Temporal gene induction patterns in sheepshead minnows exposed to 17β-estradiol. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 2006;305A(9):707-719. R831848 (2006)
Journal Article Villeneuve DL, Larkin P, Knoebl I, Miracle AL, Kahl MD, Jensen KM, Makynen EA, Durhan EJ, Carter BJ, Denslow ND, Ankley GT. A graphical systems model to facilitate hypothesis-driven ecotoxicogenomics research on the teleost brain-pituitary-gonadal axis. Environmental Science & Technology 2007;41(1):321-330. R831848 (2006)
Journal Article Villeneuve DL, Knoebl I, Larkin P, Miracle AL, Carter BJ, Denslow ND, Ankley GT. Altered gene expression in the brain and liver of female fathead minnows Pimephales promelas Rafinesque exposed to fadrozole. Journal of Fish Biology 2008;72(9):2281-2340. R831848 (2006)
Journal Article Watanabe KH, Jensen KM, Orlando EF, Ankley GT. What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas. Comparative Biochemistry and Physiology C: Toxicology & Pharmacology 2007;146(3):348-356. R831848 (2006)
Presentation Denslow ND, Orlando EF, Sepúlveda MS, Watanabe KH. Gene expression profiles for fathead minnows exposed to 17α-ethynylestradiol. Presented at the Society of Environmental Toxicology and Chemistry North American 26th Annual Meeting, Baltimore, MD, November 13-17, 2005. R831848 (2005)
R831848 (2006)
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Presentation Denslow ND, Garcia-Reyero N, Sepúlveda MS, Orlando EF. A toxicogenomics approach to endocrine disruptors in the environment. Presented at the VIIth International Congress on the Biology of Fish, St. Johns, NL, Canada, July 18-22, 2006. R831848 (2006)
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Presentation Denslow ND, Garcia-Reyero N, Matinovic D, Adelman I. Exposure of fathead minnows (Pimephales promelas) to effluent from a metropolitan sewage treatment plant reduces competitive fitness in males and alters gene expression patterns. Presented at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America, Montreal, QC, Canada, November 5-9, 2006. R831848 (2006)
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Presentation Garcia-Reyero N, Kroll K, Sepúlveda M, Watanabe K. Gene expression profiles for fathead minnows (Pimephales promelas) exposed to ethynylestradiol and the anti-estrogen ZM189,154. Presented at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America Montreal, QC, Canada, November 5-9, 2006. R831848 (2006)
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Presentation Johns SM, Sepúlveda MS, Garcia-Reyero N, Watanabe KH. Can reproductive alterations in fish exposed to endocrine disruptors be predicted by changes in gene expression? Presented at the 23rd Annual Ohio Valley Chapter Society of Environmental Toxicology and Chemistry Meeting, Fort Wayne, IN, April 20-21, 2006. R831848 (2006)
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Presentation Kroll K, Mulally N, Orlando EF, Sepúlveda MS, Watanable KH, Bencic D, Whitehead T, Villeneuve D, Ankley G, Denslow ND. Assay development to evaluate the effect of sex hormone agonists and antagonists in fathead minnows. Presented at the 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC) North America, Baltimore, MD, November 13-17, 2005. R831848 (2005)
R831848 (2006)
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Presentation Ochoa-Acuña HG, Sepúlveda MS, Orlando EF, Watanabe KH, Denslow ND. Fathead minnow metabolic rate, stroke volume, and cardiac output for use in physiologically based pharmacokinetic models. Presented at the 16th Annual Meeting of the Society of Environmental Toxicology and Chemistry Europe, The Hague, The Netherlands, May 7-11, 2006. R831848 (2006)
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Presentation Reyero NG, Barber D, Johnson K, Sepúlveda MS. Dietary exposure of largemouth bass to OCPs changes gene expression throughout the reproductive cycle. Presented at the 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America, Baltimore, MD, November 13-17, 2005. R831848 (2006)
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Presentation Sepúlveda MS, Johns SM, Garcia-Reyero N, Watanabe KH. Relationship between reproductive endpoints and gene expression patterns in fathead minnows exposed to EE2. Presented at the 14th International Conference on Environmental Bioindicators and 2nd Annual Meeting of the International Society of Environmental Bioindicators, Linthicum, MD, April 24-26, 2006. R831848 (2006)
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Presentation Sepúlveda MS, Orlando EF, Watanabe KH, Kroll K. Systems biology modeling of fathead minnow response to endocrine disruption. Presented at the 16th Annual Meeting of the Society of Environmental Toxicology and Chemistry Europe, The Hague, The Netherlands, May 7-11, 2006. R831848 (2006)
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Presentation Watanabe KH, Denslow ND, Orlando EF, Sepúlveda MS. Fathead minnow gene expression and physiologically based pharmacokinetics in response to 17α-ethynylestradiol. Presented at the National Academies' Eleventh Meeting of the Committee on Emerging Issues and Data on Environmental Contaminants: Application of Genomic Signatures, Welches, OR, December 7, 2005. R831848 (2006)
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Presentation Watanabe KH, Denslow ND, Orlando EF, Sepúlveda MS, Bencic DC, Knoeble I, Lazorchak JM, Lattier DL, Toth GP, Wang R, Ankley GT, Jensen KM, Villeneuve DL, Collette TW, Whitehead TL, Miller DH, Miracle AL. The hypothalamic-pituitary-gonadal axis in fathead minnow (Pimephales promelas): a targeted systems approach for modeling biological responses to endocrine disrupting chemicals. Presented at the Northwest Symposium for Systems Biology 2005, Richland, WA, June 20-21, 2005. R831848 (2005)
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Presentation Watanabe KH, Kroll K, Orlando EF, Sepúlveda MS. Physiologically based pharmacokinetic model of 17α-ethynylestradiol exposed fathead minnows (Pimephales promelas). Presented at the 26th Annual Meeting of the Environmental Toxicology and Chemistry North America, Baltimore, MD, November 13-17, 2005. R831848 (2005)
R831848 (2006)
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Presentation Watanabe KH, Jensen KM, Villenueve DL, Ankley GT, Orlando EF, Sepúlveda MS, Bencic DC, Whitehead TL, Miller DH, Denslow ND. Computational model of the hypothalamic-pituitary-gonadal axis in female fathead minnows (Pimephales promelas): baseline state of unexposed fish. Presented at the 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America, Baltimore, MD, November 13-17, 2005. R831848 (2005)
R831848 (2006)
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Presentation Watanabe KH, Jensen KM, Villeneuve DL, Nichols J. A physiologically based model of the hypothalamic-pituitary-gonadal axis in female fathead minnows (Pimephales promelas). Presented at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America, Montreal, Quebec, Canada, November 5-9, 2006. R831848 (2006)
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Presentation Watanabe KH, Kroll K, Reyero-Garcia N, Orlando EF. Comparison of observed and model-predicted HPG axis effects in male FHM exposed to 17α-ethynylestradiol. Presented at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America, Montreal, Quebec, Canada, November 5-9, 2006. R831848 (2006)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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