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Grantee Research Project Results

Publications Details for:

Mechanistic Approach to Screening Chemicals and Mixtures for Endocrine Activity Using an Invertebrate Model
Grant Number R831300
RFA: Development of High-Throughput Screening Approaches for Prioritizing Chemicals for the Endocrine Disruptors Screening Program (2003)


Other views: Selected publication types Journal articles Publications submitted after final report Redisplay this page with Reference Title, Journal, and Author Columns Display this page in RIS format

Journal Article (9)
Presentation (13)
Reference Type Citation Progress Report Year Document Sources
Journal Article Gorr TA, Rider CV, Wang HY, Olmstead AW, LeBlanc GA. A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter. Molecular and Cellular Endocrinology 2006;247(1-2):91-102.
abstract available     full text available
R829358 (Final)
R831300 (2005)
R831300 (2006)
R831300 (Final)
R832739 (2008)
Journal Article LeBlanc GA. Crustacean endocrine toxicology: a review. Ecotoxicology 2007;16(1):61-81.
abstract available     full text available
R826129 (Final)
R831300 (Final)
R832739 (2007)
R832739 (Final)
Journal Article Mu XY, LeBlanc GA. Cross communication between signaling pathways: Juvenoid hormones modulate ecdysteroid activity in a crustacean. Journal of Experimental Zoology Part A-Comparative Experimental Biology 2004;301A(10):793-801.
abstract available    
R826129 (Final)
R829358 (2004)
R829358 (Final)
R831300 (2004)
not available
Journal Article Mu XY, Rider CV, Hwang GS, Hoy H, LeBlanc GA. Covert signal disruption: anti-ecdysteroidal activity of bisphenol A involves cross talk between signaling pathways. Environmental Toxicology and Chemistry 2005;24(1):146-152.
abstract available     full text available
R829358 (2004)
R829358 (Final)
R831300 (2004)
R831300 (Final)
R832739 (2008)
Journal Article Olmstead AW, LeBlanc GA. The environmental-endocrine basis of gynandromorphism (intersex) in a crustacean. International Journal of Biological Sciences 2006;3(2):77-84.
abstract available     full text available
R831300 (Final)
R832739 (2006)
R832739 (2007)
R832739 (2008)
R832739 (Final)
Journal Article Rider CV, Gorr TA, Olmstead AW, Wasilak BA, LeBlanc GA. Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean. Journal of Experimental Biology 2005;208(Pt 1):15-23.
abstract available     full text available
R829358 (Final)
R831300 (2004)
R831300 (2006)
R831300 (Final)
R832739 (2008)
Journal Article Rider CV, LeBlanc GA. Atrazine stimulates hemoglobin accumulation in Daphnia magna: is it hormonal or hypoxic? Toxicological Sciences 2006;93(2):443-449.
abstract available     full text available
R829358 (Final)
R831300 (Final)
Journal Article Wang HY, Olmstead AW, Li H, LeBlanc GA. The screening of chemicals for juvenoid-related endocrine activity using the water flea Daphnia magna. Aquatic Toxicology 2005;74(3):193-204.
abstract available     full text available
R831300 (2005)
R831300 (Final)
R832739 (2008)
Journal Article Wang YH, Wang G, LeBlanc GA. Cloning and characterization of the retinoid X receptor from a primitive crustacean Daphnia magna. General and Comparative Endocrinology 2007;150(2):309-318.
abstract available     full text available
R831300 (2006)
R831300 (Final)
R832739 (2006)
R832739 (2007)
R832739 (Final)
Presentation LeBlanc GA, Olmstead AW, Rider CV, Hoy H, Wasilak B. Coordinate regulation of hemoglobin production and reproduction in a crustacean by the hormone methyl farnesoate and their dysregulation by insecticidal insect growth regulators. Presented at e.hormone 2003, New Orleans, LA, October 16-18, 2003.
R831300 (2004)
not available
Presentation LeBlanc GA, Olmstead AW, Mu X, Rider CV, et al. Linking endocrinology to assay: Assessing endocrine-disrupting toxicity of chemicals to invertebrates. Presented at the U.S. Environmental Protection Agency Program Review Meeting, Research Triangle Park, NC, 2004.
R831300 (2005)
not available
Presentation LeBlanc GA. Do EAT-based screening assays offer protection to invertebrates? Presented at the 26th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Baltimore, MD, November 13-17, 2005.
R831300 (2006)
R831300 (Final)
not available
Presentation LeBlanc GA. Environmental signaling: sex is not just in the genes. Presented at the Carolina Society of Environmental Toxicology and Chemistry Annual Meeting, Raleigh, NC, 2005.
R831300 (2005)
not available
Presentation LeBlanc GA, Gooding MP, Olmstead AW, Mu X, Rider CV, Wang HY, Bai R. Daphnids and gastropods as models to assess endocrine function and toxicant-mediated dysfunction in invertebrates. Presented at the Meeting of the Daphnia Genomics Consortium, Bloomington, IN, January 17-19, 2006.
R831300 (2006)
R831300 (Final)
not available
Presentation Mu X, Hoy H, LeBlanc GA. Antiecdysteroidal activity of juvenoid hormones in a crustacean. Presented at e.hormone 2003, New Orleans, LA, October 16-18, 2003.
R831300 (2004)
not available
Presentation Olmstead AW. Daphnia magna: a crustacean model for juvenoid endocrine disruption. Presented at the 26th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Baltimore, MD, November 13-17, 2005.
R831300 (2006)
R831300 (Final)
not available
Presentation Reeves BS, Wang HY, LeBlanc GA. Developmental toxicity of nitrates: is there a mechanistic link to nitric oxide? Presented at the Society of Toxicology 2006 Conference, San Diego, CA, March 5-9, 2006.
R831300 (2006)
R831300 (Final)
not available
Presentation Reeves BS, Wang YH, LeBlanc GA. Mechanistic evaluation of the developmental toxicity of nitrogen oxides. Presented at the 46th Annual Meeting of the Society of Toxicology and ToxExpo, Charlotte, NC, March 25-29, 2007.
R831300 (Final)
not available
Presentation Rider CV, Buslinger L, Olmstead AW, Wasilak BA, et al. Endocrine active insecticides stimulate a putative stress-signaling pathway in daphnids. Presented at the Fourth Society of Environmental Toxicology and Chemistry World Congress, Portland, OR, 2004.
R831300 (2005)
not available
Presentation Thomson S, Wang HY, Reeves BS, LeBlanc GA. Nuclear receptor gene superfamily of Daphnia pulex. Presented at the Meeting of the Daphnia Genomics Consortium, Bloomington, IN, July 7-9, 2007.
R831300 (Final)
not available
Presentation Wang HY, Wang G, LeBlanc GA. Interaction of retinoid X receptor with environmental chemicals. Presented at the 46th Annual Meeting of the Society of Toxicology and ToxExpo, Charlotte, NC, March 25-29, 2007.
R831300 (Final)
not available
Presentation Wang H, Mu X, LeBlanc GA. Rapid detection of (anti)ecdysteroid and (anti)juvenoid activities of chemicals. Presented at the Fourth Society of Environmental Toxicology and Chemistry World Congress, Portland, OR, 2004.
R831300 (2005)
not available

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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