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Extramural Research

Grantee Research Project Results

Grantee Research Project Results

Publications Details for:

Center for Child Environmental Health Risks Research
Grant Number R826886
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)


Other views: Selected publication types Journal articles Publications submitted after final report Redisplay this page with Reference Title, Journal, and Author Columns Display this page in RIS format

Book Chapter (3)
Dissertation/Thesis (3)
Journal Article (72)
Presentation (1)
Reference Type Citation Progress Report Year Document Sources
Book Chapter Brophy VH, Jarvik GP, Furlong CE. PON1 polymorphisms. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Kluwer Academic Publishers, 2002, pp. 53-77. R826886 (2000)
R826886C002 (2001)
R826886C002 (2002)
R831709 (2007)
Book Chapter Costa LG, Li W-F, Richter RJ, Shih DM, Lusis AJ, Furlong CE. PON1 and organophosphate toxicity. Chapter 8. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Kluwer Academic Publishers, 2002. R826886 (2000)
R826886C002 (2001)
R826886C002 (2002)
Book Chapter Costa LG, Furlong CE. Perspectives in PON1 research. Chapter 10. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Kluwer Academic Publishers, 2002. R826886 (2000)
R826886C002 (2002)
Dissertation/Thesis Adams JC. A physiologically-based toxicokinetic model of xylene inhalation exposure in Caucasian men and a correlation study of individual kinetic and anthropometric parameters determined from physiologic modeling of controlled xylene exposure. M.S. Thesis. Department of Environmental Health, University of Washington, Seattle, WA, 2000. R826886 (2000)
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Dissertation/Thesis Curl C. Evaluation of organophosphorus pesticide exposure in children of agricultural families in the Lower Yakima Valley. M.S. Thesis. Department of Environmental Health, University of Washington, Seattle, WA, August 2000. R826886 (2000)
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Dissertation/Thesis Palcisko G. Children’s exposure to lead and arsenic in orchard soils. M.S. Thesis. Department of Environmental Health, University of Washington, Seattle, WA, August 2000. R826886 (2000)
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Journal Article Andersen ME, Conolly RB, Faustman EM, Kavlock RJ, Portier CJ, Sheehan DM, Wier PJ, Ziese L. Quantitative mechanistically based dose-response modeling with endocrine-active compounds. Environmental Health Perspectives 1999;107(Suppl 4):631-638. R826886 (2000)
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Journal Article Bartell SM, Ponce RA, Takaro TK, Zerbe RO, Omenn GS, Faustman EM. Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Analysis 2000;20(1):87-99. R826886 (2000)
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Journal Article Bogdanffy MS, Daston G, Faustman EM, Kimmel CA, Kimmel GL, Seed J,Vu V. Harmonization of cancer and non-cancer risk assessment:proceedings of a consensus-building workshop. Toxicological Science 2001;61(1):18-31. R826886 (2000)
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Journal Article Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 2000;10(5):453-460. R826886 (2000)
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Journal Article Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436. R826886 (2000)
R826886C002 (2001)
R831709 (2007)
Journal Article Brophy VH, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001;11(1):77-84. R826886 (2000)
R826886C002 (2001)
Journal Article Burbacher TM, Grant KS. Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicology and Teratology 2000;22(4):475-486. R826886 (2000)
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Journal Article Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. Journal of Neuroscience 2001;21(2):434-443. R826886 (2000)
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Journal Article Chan GC, Lernmark U, Xia Z, Storm DR. DNA elements of the type 1 adenylyl cyclase gene locus enhance reporter gene expression in neurons and pinealocytes. European Journal of Neuroscience 2001;13(11):2054-2066. R826886 (2000)
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Journal Article Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chemico–Biological Interactions 1999;119-120:429-438. R826886 (2000)
R826886C002 (2000)
Journal Article Costa LG. The emerging field of ecogenetics. Neurotoxicology 2000;21(1-2):85-89. R826886 (2000)
R826886C002 (2000)
Journal Article Costa LG, Guizzetti M, Lu H, Bordi F, Vitalone A, Tita B, Palmery M, Valeri P, Silvestrini B. Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology 2001;160(1-3):19-26. R826886 (2000)
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Journal Article Costa LG. Pesticide exposure:differential risk for neurotoxic outcomes due to enzyme polymorphisms. Clinics in Occupational and Environmental Medicine 2001;1:511-523. R826886 (2000)
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Journal Article Costa LG, Guizzetti M, Burry , Oberdoerster J. Developmental neurotoxicity:do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. Toxicology Letters 2002;127(1-3):197-205. R826886 (2000)
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Journal Article Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. R826886 (2000)
R826886C002 (2002)
R831709 (2005)
R831709 (2007)
R831709C002 (2004)
Journal Article Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TF, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002;110(12):A787-792. R826886 (2000)
R826886C003 (2001)
R826886C003 (2002)
R826886C004 (2001)
R826886C004 (2002)
Journal Article Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122. R826886 (2000)
R826886C004 (2002)
R831709 (2005)
R831709 (2007)
Journal Article Faustman EM, Lewandowski TA, Ponce RA, Bartell SM. Biologically based dose-response models for developmental toxicants:lessons from methylmercury. Inhalation Toxicology 1999;11(6-7):559-572. R826886 (2000)
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Journal Article Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children's susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21. R825173 (1999)
R825173 (2000)
R826886 (2000)
Journal Article Faustman EM, Ponce RA, Ou YC, Mendoza MA, Lewandowski T, Kavanagh T. Investigations of methylmercury-induced alterations in neurogenesis. Environmental Health Perspectives 2002;110(Suppl 5):859-864. R826886 (2000)
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Journal Article Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 2000;108(6):515-520. R826886 (2000)
R826886C004 (2001)
Journal Article Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC. Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Suppl 2):662-671. R825171 (2000)
R826886 (2000)
R826886C004 (2001)
Journal Article Fenske RA, Kedan G, Lu C, Fisker-Andersen JA, Curl CL. Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. Journal of Exposure Analysis and Environmental Epidemiology 2002;12(1):21-28. R826886 (2000)
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Journal Article Fenske RA, Lu C, Barr D, Needham L. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environmental Health Perspectives 2002;110(5):549-553. R826886 (2000)
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Journal Article Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z. Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. Journal of Neuroscience2001;21(13):4657-4667. R826886 (2000)
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Journal Article Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000;21(1-2):91-100. R826886 (2000)
R826886C002 (2000)
R826886C002 (2001)
Journal Article Furlong CE. PON1 status and neurologic symptom complexes in Gulf War veterans. Genome Research 2000;10(2):153-155. R826886 (2000)
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Journal Article Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. Neurotoxicology 2000;21(4):581-587. R826886 (2000)
R826886C002 (2001)
Journal Article Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG. Genetic factors in susceptibility:serum PON1 variation between individuals and species. Human and Ecological Risk Assessment 2002;8(1):31-43. R826886 (2000)
R826886C002 (2002)
Journal Article Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002;3(3):341-348. R826886 (2000)
R826886C002 (2002)
Journal Article Garlock TJ, Shirai JH, Kissel JC. Adult responses to a survey of soil contact-related behaviors. Journal of Exposure Analysis and Environmental Epidemiology 1999;9(2):134-142. R826886 (2000)
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Journal Article Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. Journal of Cell Biology 2000;150(2):335-47. R826886 (2000)
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Journal Article Gohlke JM, Griffith WC, Bartell SM, Lewandowski TA, Faustman EM. A computational model for neocortical neuronogenesis predicts ethanol-induced neocortical neuron number deficits. Developmental Neuroscience 2002;24(6):467-477. R826886 (2000)
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Journal Article Goldstein BD, Erdal S, Burger J, Faustman EM, Friedlander BR, Greenberg M, Leschine TM, Powers CW, Waishwell L, Williams B. Stakeholder participation:Experience from the CRESP program. Environmental Epidemiology and Toxicology 2000;2:103-111. R826886 (2000)
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Journal Article Hetman M, Kanning KC, Smith-Cavanaugh JE, Xia Z. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular-signal-regulated kinase and phosphatidylinositol-3 kinase. Journal of Biological Chemistry 1999;(274):22569-22580. R826886 (2000)
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Journal Article Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. Journal of Neuroscience 2000;20(7):2567-2574. R826886 (2000)
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Journal Article Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, Schellenberg GD, Furlong CE. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arteriosclerosis, Thrombosis, and Vascular Biology 2000;20(11):2441-2447. R826886 (2000)
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Journal Article Judd NL, Griffith WC, Ylitalo GM, Faustman EM. Alternative strategies for PCB risk reduction from contaminated seafood:options for children as susceptible populations. Bulletin of Environmental Contaminants and Toxicology 2002;69:847-854. R826886 (2000)
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Journal Article Koch D, Lu CS, Fisker-Andersen J, Jolley L, Fenske RA. Temporal association of children's pesticide exposure and agricultural spraying: Report of a longitudinal biological monitoring study. Environmental Health Perspectives 2002;110(8):829-833. R825171 (2000)
R826886 (2000)
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Journal Article Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg M. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 2002;34:221-233. R826886 (2000)
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Journal Article Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM. Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. Teratology 2002;66(5):235-241. R825358 (Final)
R826886 (2000)
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Journal Article Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in- vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000;10(9):767-779. R826886 (2000)
R826886C002 (2000)
R826886C002 (2001)
Journal Article Little SA, Mirkes PE. Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos. Toxicology and Applied Pharmacology 2002;181(2):142-151. R826886 (2000)
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Journal Article Lu CS, Knutson DE, Fisker-Andersen J, Fenske RA. Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle metropolitan area. Environmental Health Perspectives 2001;109(3):299-303. R825171 (2000)
R826886 (2000)
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Journal Article Lu C, Fenske RA. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environmental Health Perspectives 1999;107(6):463-467. R826886 (2000)
R826886C004 (2001)
Journal Article Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000;84(3):290-302. R826886 (2000)
R826886C004 (2001)
Journal Article Mendoza MAC, Ponce RA, Ou YC, Faustman EM. p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicology and Applied Pharmacology 2002;178(2):117-125. R825358 (Final)
R826886 (2000)
Journal Article Mirkes PE, Little SA. Teratogen-induced cell death in postimplantation mouse embryos:differential tissue sensitivity and hallmarks of apoptosis. Cell Death and Differentiation 1998;5(7):592-600. R826886 (2000)
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Journal Article Mirkes PE, Cornel LM, Wilson KL, Dilmann WH. Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. Developmental Dynamics 1999;214(2):159-170. R826886 (2000)
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Journal Article Mirkes PE, Little SA. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicology and Applied Pharmacology 2000;162(3):197-206. R826886 (2000)
R826886C001 (2001)
Journal Article Mirkes PE, Wilson KL, Cornel LM. Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. Teratology 2000;62(1):14-25. R826886 (2000)
R826886C001 (2001)
Journal Article Mirkes PE. 2001 Warkany lecture:to die or not to die, the role of apoptosis in normal and abnormal mammalian development. Teratology 2002;65(5):228-239. R826886 (2000)
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Journal Article Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA. Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. Journal of Analytical Toxicology 1999;23(4):230-236. R825171 (1999)
R825171 (2000)
R826886 (2000)
R826886C004 (2001)
Journal Article Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA. Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. Journal of the AOAC International 2002;85(1):36-43. R826886 (2000)
R826886C004 (2001)
R826886C004 (2002)
Journal Article Namgung U, Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. Journal of Neuroscience 2000;20(17):6442-6451. R826886 (2000)
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Journal Article Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicology and Applied Pharmacology 2001;174(2):130-138. R826886 (2000)
R826886C001 (2002)
Journal Article Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology 1999;157(3):203-212. R825358 (Final)
R826886 (2000)
Journal Article Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology 1999;20(5):793-804. R825358 (Final)
R826886 (2000)
Journal Article Polifka JE, Faustman EM. Developmental toxicity:web resources for evaluating risk in humans. Toxicology 2002;173(1-2):35-65. R826886 (2000)
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Journal Article Ponce RA, Bartell SM, Wong EY, LaFlamme D, Carrington C, Lee RC, Patrick DL, Faustman EM, Bloger M. Use of quality-adjusted life year weights with dose-response models for public health decisions:A case study of the risks and benefits of fish consumption. Risk Analysis 2000;20:529-542. R826886 (2000)
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Journal Article Ponce RA, Wong EY, Faustman EM. Quality adjusted life years (QALYs) and dose-response models in environmental health policy analysis--methodological considerations. Science of the Total Environment 2001; 274(1-3):79-91. R826886 (2000)
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Journal Article Poser S, Impey S, Trinh K, Xia Z, Storm DR. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO Journal 2000;19(18):4955-4966. R826886 (2000)
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Journal Article Richter RJ, Furlong CE. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 1999;9(6):745-753. R826886 (2000)
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Journal Article Sanga RN, Bartell SM, Ponce RA, Boischio AAP, Joiris CR, Pierce CH, Faustman EM. Effects of uncertainties on exposure estimates to methylmercury:A Monte Carlo analysis of biomarkers of exposure vs. predictive dietary estimation. Risk Analysis 2001;21(5):859-868. R826886 (2000)
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Journal Article Thompson B, Coronado G, Puschel K, Allen E. Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environmental Health Perspectives 2001;109(Suppl 3):443-448. R826886 (2000)
R826886C003 (2001)
R826886C003 (2002)
R826886C004 (2001)
R826886C004 (2002)
Journal Article Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53. R826886 (2000)
R826886C003 (2002)
R831709 (2005)
R831709 (2007)
R831709C003 (2004)
Journal Article Umpierre CC, Little SA, Mirkes PE. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 2001;63(3):134-143. R826886 (2000)
R826886C001 (2001)
R826886C001 (2002)
Journal Article Vicini P, Pierce CH, Dills RL, Morgan MS, Kalman DA. Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. Risk Analysis 1999;19(6):1127-1134. R826886 (2000)
Journal Article Wong EY, Shirai JH, Garlock TJ, Kissel JC. Adult proxy responses to a survey of children's dermal soil contact activities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Pt 1):509-517. R826886 (2000)
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Journal Article Wong EY, Shirai JH, Garlock TJ, Kissel JC. Survey of selected activities relevant to exposures to soils. Bulletin of Enviornmental Contaminants and Toxicology 2000;65(4):443-450. R826886 (2000)
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Journal Article Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf Jr. WE, Feuerstein GZ. TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. Journal of Biological Chemistry 1999;274(3):1479-1486. R826886 (2000)
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Journal Article Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. Journal of Biological Chemistry 2002;277(25):22909-22914. R826886 (2000)
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Presentation Curl C, Kissel J, Fenske R, Shirai J, et al. Baseline data from an EPA/NIEHS Children’s Environmental Health Center Community Intervention Project in Washington State. Presented at the Annual Meeting of the ISEA, Monterey, CA. R826886 (2000)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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