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Grantee Research Project Results

Publications Details for:

Developmental Exposure to Endocrine Disruptors: Fertility and Gene Expression Profiles
Grant Number R827402
RFA: Endocrine Disruptors (1999)


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Abstract (4)
Book Chapter (1)
Journal Article (8)
Meeting (3)
Presentation (49)
Proceedings (1)
Reference Type Citation Progress Report Year Document Sources
Abstract Fielden MR, Halgren RG, Fong CJ, Chou K, Saama PM, Zacharewski TR. Reproductive and genomic effects of gestational and lactational exposure to diethylstilbestrol in male mice. Toxicology 2001;164(S1-3):123.
R827402 (Final)
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Abstract Han J, Zacharewski T, Saama PM, Chou K. Effects of gestational and postnatal exposure of 17alpha-ethynylestradiol on ovulation and egg fertilizing ability in mice. Biology of Reproduction 2002;66(Suppl. 1):302.
R827402 (Final)
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Abstract Han J, Fielden M, Sammy SM, Saama PM, Zacharewski T, Chou K. Effects of gestational and postnatal exposure of genistein on ovulation and egg fertilizing ability in mice. Toxicology Society 2002;66(Suppl. 1):377.
R827402 (Final)
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Abstract Saama PM, Fielden M, Han J, Sammy SM, Zacharewski T, Chou K. Quantitative profile of testicular gene expression patterns in mice exposed to diethylstilbestrol during gestation and lactation. Toxicology Society 2002;66(Suppl. 1):298.
R827402 (Final)
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Book Chapter Zacharewski T, Fertuck K, Fielden M, Matthews J. Mechanistically-based assays for the identification and characterization of endocrine disruptors. In: Vanden Heuvel JP, Greenlee WF, Perdew GH, Mattes WB, eds. Comprehensive Toxicology Volume 14: Cellular and Molecular Toxicology. Elsiever Science B.V., Amsterdam, The Netherlands, 2002, pp. 559-582.
R826301 (2001)
R826301 (Final)
R827402 (2001)
R827402 (Final)
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Journal Article Fielden MR, Zacharewski TR. Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicological Sciences 2001;60(1):6-10.
R827402 (2001)
R827402 (Final)
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Journal Article Fielden MR, Halgren RG, Dere E, Zacharewski TR. GP3: GenePix post-processing program for automated analysis of raw microarray data. Bioinformatics 2002;18(5):771-773.
R827402 (2001)
R827402 (Final)
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Journal Article Fielden MR, Halgren RG, Fong CJ, Staub C, Johnson L, Chou K, Zacharewski TR. Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression. Endocrinology 2002;143(8):3044-3059.
R827402 (Final)
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Journal Article Fielden MR, Matthews JB, Fertuck KC, Halgren RG, Zacharewski TR. In silico approaches to mechanistic and predictive toxicology: An introduction to bioinformatics for toxicologists. Critical Reviews in Toxicology 2002;32(2):67-112.
abstract available    
R827402 (2001)
R827402 (Final)
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Journal Article Fielden MR, Fong CJ, Haslam SZ, Zacharewski TR. Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure. Toxicology Letters 2002;133(2-3):181-191.
abstract available     full text available
R827402 (Final)
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Journal Article Fielden MR, Samy SM, Chou KC, Zacharewski TR. Effect of human dietary exposure levels of genistein during gestation and lactation on reproductive development and sperm quality in mice. Food Chemistry and Toxicology 2003;41(4):447-454.
R827402 (Final)
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Journal Article Halgren RG, Fielden MR, Fong CJ, Zacharewski TR. Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones. Nucleic Acids Research 2001;29(2):582-588
R827401 (2001)
R827402 (2001)
R827402 (Final)
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Journal Article Saama PM. Sparse preconditioned iterative solvers for ill-posed mixed model equations. Society for Industrial and Applied Mathematics Journal on Numerical Analysis.
R827402 (Final)
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Meeting Saama PM. Bioinformatics: what to do with the microarray data? Michigan State University joint Animal Physiology, Lactation, and Genetics Seminar Series, E. Lansing, MI, December 5, 2000.
R827402 (2001)
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Meeting Zacharewski T. Male reproductive and genomic testicular effects of developmental exposure to diethylstilbestrol in mice. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, November 7, 2000.
R827402 (2001)
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Meeting Zacharewski T. Reproductive and genomic testicular effects following developmental exposure to diethylstilbestrol in mice. Institute of Chemical Toxicology/Environmental Health Sciences Center Seminar Series, Wayne State University, Detroit, MI, February 22, 2001.
R827402 (2001)
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Presentation Fertuck K, Zacharewski T. Assessment of estrogenic endocrine disruptors using global gene expression approaches. Presented at the Scientific Committee on Problems of the Environment/International Union of Pure and Applied Chemistry International Symposium on Endocrine Active Substances, Yokohama, Japan, November 17-21, 2002.
R827402 (Final)
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Presentation Fertuck K, Zacharewski T. Using rodents as an indicator of human responses to estrogen exposure. Presented at the U.S. Environmental Protection Agency Region 10 2003 Genomics Seminar Series, Seattle, WA, May 21, 2003.
R827402 (Final)
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Presentation Fielden MR, Halgren RG, Fong C, Boutros P, Chou K, Saama P, Zacharewski TR. Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Toxicogenomics in Predictive and Discovery Toxicology. Presented at the Early Toxicity Screening in Drug Discovery Meeting, Institute for Scientific Exchange, Baltimore, MD, October 10, 2000.
R827402 (2001)
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Presentation Fielden MR, Halgren RG, Fong CJ, Boutros P, Chou K, Saama PM, Zacharewski TR. Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Poster presented at the Consortium on Environmental and Drug Safety Workshop, Toronto, Ontario, Canada, September 29-October 1, 2000.
R827402 (2001)
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Presentation Fielden MR, Halgren RG, Fong C, Boutros P, Chou K, Saama P, Zacharewski TR. Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Presented at the 58th Annual EHS Center Directors' Meeting on Functional Genomics, Proteomics and High Through-put Technologies: Tools for the 21st Century, Institute of Chemical Toxicology, Detroit, MI, October 16, 2000.
R827402 (2001)
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Presentation Fielden MR, Halgren RG, Fong CJ, Chou K, Saama P, Zacharewski TR. Male reproductive and genomic effects of developmental exposure to diethylstilbestrol in mice. Presented at the Michigan State University Genetics Symposium on Global Analysis of Complex Genetic Systems, E. Lansing, MI, April 21, 2001.
R827402 (2001)
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Presentation Fielden MR, Halgren RG, Fong CJ, Chou K, Saama P, Zacharewski TR. Male reproductive and genomic effects of developmental exposure to diethylstilbestrol in mice. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001.
R827402 (2001)
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Presentation Fielden MR, Halgren RG, Fong CJ, Chou K, Saama P, Zacharewski TR. Reproductive and genomic effects of gestational and lactational exposure to diethylstilbestrol in male mice. Poster presented at the 9th International Congress of Toxicology Annual Meeting, Brisbane, Australia, July 8-12, 2001. NOTE: Supported by the 2001 Robert L. Dixon International Travel Award in Reproductive Toxicology, and sponsored by the Toxicology Educational Foundation of the Society of Toxicology.
R827402 (2001)
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Presentation Halgren RG, Fielden MR, Fong CJ, Zacharewski TR. Assessment of clone identity and sequence fidelity within the IMAGE cDNA Library. Presented at the Mechanisms of Toxicity, Gordon Research Conferences, Plymouth, NH, July 23-28, 2000.
R827402 (2001)
R827402 (Final)
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Presentation Halgren RG, Fielden MR, Fong CJ, Boutros P, Zacharewski T. dbmTEST: a database of transcripts expressed in spermatogenesis and testis. Presented at the 58th Annual EHS Center Directors' Meeting on Functional Genomics, Proteomics and High Through-put Technologies: Tools for the 21st Century, Institute of Chemical Toxicology, Detroit, MI, October 16, 2000.
R827402 (2001)
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Presentation Han J, Fielden MR, Halgren RG, Zacharewski TR, Saama PM, Chou K. Effects of gestational and postnatal exposure to diethylstilbesterol on female reproduction. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001.
R827402 (2001)
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Presentation Zacharewski TR. Reproductive toxicology: databases, arrays and analysis. Presented at the Mid-Atlantic Chapter of the Society of Toxicology Spring Symposium - Genomics and Proteomics: Applications to Toxicology, East Windsor, NJ, May 12, 2000.
R827402 (Final)
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Presentation Zacharewski TR. The application of toxicogenomics in predictive toxicology. Presented at the New Techniques To Increase Drug Candidate Survivability Meeting, Strategic Research Institute, Philadelphia, PA, September 11-12, 2000.
R827402 (2001)
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Presentation Zacharewski TR. Toxicogenomic assessment of endocrine disruptors. Presented at the Department of Biology Seminar Series, University of Ottawa, Ottawa, Ontario, Canada, September 12, 2002.
R827402 (Final)
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Presentation Zacharewski TR. Toxicogenomics in predictive and discovery toxicology. Presented at the Early Toxicity Screening in Drug Discovery Meeting, Institute for Scientific Exchange, Baltimore, MD, October 10, 2000.
R827402 (2001)
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Presentation Zacharewski T. Application of new technologies and implications for risk assessment. Presented at the U.S. Environmental Protection Agency Regional Workshop on Endocrine Disruptors, EPA Region 4, Atlanta, GA, May 1-3, 2001.
R826301 (2001)
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Assessment of estrogenic endocrine disruptors: estrogen receptor interactions, toxicogenomics and male reproductive toxicity. Presented to the Curagen Corporation, New Haven, CT, August 7, 2001.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Developmental exposure to endocrine disruptors: fertility and gene expression profiles using bioassays. Presented at the PITTCON 2001 Meeting on Trends and Challenges in the Analysis of Endocrine Disrupting Chemicals, New Orleans, LA, March 5-8, 2001.
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Endocrine disruption as related to our food supply. The Science of Pre-Harvest Food Safety-Bringing Sound Science to the Table. Presented at the Kellogg Hotel and Conference Center, Michigan State University, E. Lansing, MI, May 8-10, 2001.
R826301 (2001)
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Endocrine disruptor-estrogen receptor interactions: the molecular basis for differential activity between species. Presented to the Institute of Cellular and Molecular Biosciences, University of Tokyo, Tokyo, Japan, January 30, 2002.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Endocrine disruptor-estrogen receptor interactions: the molecular basis for differential activity between species. Presented to the National Institute of Health Sciences, Tokyo, Japan, January 28, 2002.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Future directions in toxicological research: my biased view. Presented at the Consortium Workshop on Environmental and Drug Safety (Clinical, Cellular and Molecular Toxicology), Toronto, Ontario, Canada, September 29-October 1, 2000.
R827402 (2001)
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Presentation Zacharewski T. Gene expression profiling in mechanistic and predictive toxicology. Presented at the American Society for Pharmacology and Experimental Therapeutics Division of Toxicology Symposium/Roundtable-Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile? 2002 Annual Experimental Biology Meeting, New Orleans, LA, April 23, 2002.
R827402 (Final)
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Presentation Zacharewski T. Incorporating toxicogenomics into mechanistic toxicology and risk assessment. How useful will genomics, proteomics, and metabonomics be in chemical risk assessment for humans? Presented to the Occupational and Environmental Toxicology Group of the Royal Society of Chemistry Society of Chemical Industry, London, England, September 5, 2003.
R827402 (Final)
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Presentation Zacharewski T. Incorporating toxicogenomics into predictive and mechanistic drug development and safety assessments. Presented at Sumitomo Chemical, Osaka, Japan, January 25, 2002.
R827402 (Final)
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Presentation Zacharewski T. Incorporating toxicogenomics into predictive and mechanistic drug development and safety assessments. Presented at Novartis, Summit, NJ, February 28, 2002.
R827402 (Final)
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Presentation Zacharewski T. Incorporating toxicogenomics into predictive and mechanistic toxicology: a case study. Presented at the Cambridge Healthtech Institute's 8th Annual High-Throughput Screening, Genomic, Drug Discovery, Chemoinformatics Conference: Making Drug Development Faster, Cheaper and Smarter, Philadelphia, PA, June 11-13, 2001.
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Incorporation of a systems toxicology approach into mechanistic and predictive toxicology. Presented at Biogen's 1st Annual Preclinical and Clinical Development Science Offsite Symposium, Ogunquit, ME, October 23, 2003.
R827402 (Final)
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Presentation Zacharewski T. Incorporation of computational approaches into mechanistic and predictive toxicology. Presented at the Society of Toxicology of Canada, Montreal, Quebec, Canada, December 8-9, 2003.
R827402 (Final)
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Presentation Zacharewski T. Incorporation of computational approaches into mechanistic and predictive toxicology. Presented at the Center for Biological Modelings Biological Networks Symposium, Michigan State University, East Lansing, MI, October 17, 2003.
R827402 (Final)
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Presentation Zacharewski T. Incorporation of toxicogenomics into mechanistic and predictive toxicology. Presented at the Department of Pharmaceutical Sciences, Pharmacy and Health Sciences, Eugene Applebaum College, Wayne State University, Detroit, MI, December 11, 2002.
R827402 (Final)
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Presentation Zacharewski T. Incorporation of toxicogenomics into mechanistic and predictive toxicology. Presented at the Research Center for Genomic Research, Saitama Medical School, Siatama, Japan, October 18, 2002.
R827402 (Final)
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Presentation Zacharewski T. Incorporation of toxicogenomics into mechanistic and predictive toxicology. Presented at the Department of Environmental Engineering, Kyoto University, Kyoto, Japan, October 21, 2002.
R827402 (Final)
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Presentation Zacharewski T. Incorporation of toxicogenomics into mechanistic and predictive toxicology. Presented at Abbott Laboratories, Abbott Park, IL, August 21, 2002.
R827402 (Final)
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Presentation Zacharewski T. Integrating toxicogenomics into predictive and discovery toxicology. Presented at the 8th International Meeting of the Environmental Mutagenesis Society-Functional Genomics Satellite Meeting, Seattle, WA, October 16-18, 2001.
R827402 (Final)
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Presentation Zacharewski T. Integrating toxicogenomics into predictive and mechanistic toxicology. Presented at the Lorne Genome Conference, Lorne, Australia, February 16-20, 2003.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Male reproductive and genomic testicular effects of developmental exposure to diethylstilbestrol in mice. Presented at Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, November 7, 2000.
R827402 (Final)
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Presentation Zacharewski T. Male reproductive and testicular genomic effects of developmental exposure to diethylstilbestrol in mice. Presented at Chiba University, Chiba, Japan, January 28, 2002.
R827402 (Final)
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Presentation Zacharewski T. Male reproductive and testicular genomic effects of developmental exposure to diethylstilbestrol in mice. Presented at the U.S.-Japan International Workshop for Endocrine Disrupting Chemicals, National Institute for Environmental Studies, Tsukuba, Japan, February 28-March 3, 2001.
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Male reproductive toxicogenomics: the effect of developmental exposure to endocrine disruptors on spermatogenesis and testicular gene expression. Presented at the National Institute of Health Sciences, Tokyo, Japan, December 14, 1999.
R827402 (Final)
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Presentation Zacharewski T. Reproductive and genomic testicular effects following developmental exposure to diethylstilbestrol in mice. Presented at the Institute of Chemical Toxicology/Environmental Health Sciences Center Seminar Series, Wayne State University, Detroit, MI, February 22, 2001.
R827402 (Final)
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Presentation Zacharewski T. Reproductive toxicogenomics: effect of estrogenic substances on spermatogenesis and testicular gene expression. Presented at the United States and European Community Consortium on Molecular Toxicology Workshop on Toxicogenomics, London, England, September 9, 1999.
R827402 (Final)
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Presentation Zacharewski T. Toxicogenomic approaches to assess endocrine disruptors. Presented to the National Institute of Health Sciences, Tokyo, Japan, January 29, 2002.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Toxicogenomic assessment of endocrine disruptors. Presented at the Michigan Chapter of the Society of Toxicology Annual Meeting, Michigan State University, East Lansing, MI, November 1, 2002.
R827402 (Final)
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Presentation Zacharewski T. Toxicogenomic assessment of estrogenic endocrine disruptors. Presented at the Department of Bioenvironmental Research, Center for Integrative Bioscience, Okazaki National Research Institute, Okazaki, Japan, October 24, 2002.
R827402 (Final)
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Presentation Zacharewski T. Toxicogenomic assessment strategies for estrogenic endocrine disruptors. Presented at the 2002 Toxicogenomics International Forum, Okazaki, Japan, October 23, 2002.
R827402 (Final)
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Presentation Zacharewski, T. Toxicogenomic assessment of endocrine disruptors. Presented at the International Symposium on Environmental Endocrine Disruptors 2001, Tsukuba, Japan, December 15-17, 2001.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski, T. Toxicogenomic assessment strategies for estrogenic endocrine disruptors. Presented to the National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, June 5, 2002.
R826301 (2001)
R827402 (Final)
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Presentation Zacharewski TR. Incorporation of toxicogenomics into mechanistic and predictive toxicology. Presented at Health Canada-Healthy Environments and Consumer Safety Branch, Safe Environments Programme, Environmental and Occupational Toxicology Division, Bureau of Environmental Health Science, Ottawa, Ontario, Canada, September 11, 2002.
R827402 (Final)
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Proceedings Saama PM. Performance of the iterated bootstrap and the linear mixed model in the assessment of altered gene expression using genome-wide expression data from cDNA microarray hybridization. In: Proceedings of the Lake Tahoe Symposium on Microarray Algorithms and Statistical Analysis, Tahoe City, CA, November 9-12, 1999.
R827402 (Final)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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