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NCER Grantee Research Project Results

Publications Details for:

Species-Specific Endocrine Disruption: PCB- and PAH-Induced Estrogenic Effects
Grant Number R826301
RFA: Endocrine Disruptors (1997)


Other views: Selected publication types Journal articles Publications submitted after final report Redisplay this page with Reference Title, Journal, and Author Columns Display this page in RIS format

Book Chapter (1)
Journal Article (10)
Presentation (38)
Symposium (1)
Reference Type Citation Progress Report Year Document Sources
Book Chapter Zacharewski T, Fertuck K, Fielden M, Matthews J. Mechanistically-based assays for the identification and characterization of endocrine disruptors. In: Vanden Heuvel JP, Greenlee WF, Perdew GH, Mattes WB, eds. Comprehensive Toxicology Volume 14: Cellular and Molecular Toxicology. Elsiever Science B.V., Amsterdam, The Netherlands, 2002, pp. 559-582. R826301 (2001)
R826301 (Final)
R827402 (2001)
R827402 (Final)
not available
Journal Article Celius T, Matthews JB, Giesy JP, Zacharewski TR. Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17 beta or alpha-zearalenol. Journal of Steroid Biochemistry and Molecular Biology 2000;75(2-3):109-119. R826301 (2000)
R826301 (Final)
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Journal Article Fertuck KC, Matthews JB, Zacharewski TR. Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicological Sciences 2001;59(2):231-240. R826301 (2001)
R826301 (Final)
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Journal Article Fertuck KC, Kumar S, Sikka HC, Matthews JB, Zacharewski TR. Interaction of PAH-related compounds with the and isoforms of estrogen receptor. Toxicology Letters 2001;121(3):167-177. R826192 (Final)
R826301 (2001)
R826301 (Final)
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Journal Article Huang YW, Matthews JB, Fertuck KC, Zacharewski TR. Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Environmental Toxicology and Chemistry 2005;24(8):2002-2009 R826301 (Final)
not available
Journal Article Matthews JB, Twomey K, Zacharewski TR. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta. Chemical Research in Toxicology 2001;14(2):149-157 R826301 (Final)
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Journal Article Matthews JB, Clemons JH, Zacharewski TR. Reciprocal mutagenesis between human α(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures. Molecular and Cellular Endocrinology 2001;183(1-2):127-139 R826301 (2001)
R826301 (Final)
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Journal Article Matthews JB, Fertuck KC, Celius T, Huang YW, Fong CJ, Zacharewski TR. Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species. Journal of Steroid Biochemistry and Molecular Biology 2002;82(2-3):181-194 R826301 (Final)
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Journal Article Matthews J, Zacharewski T. Differential binding affinities of PCBs, HO-PCBs, and aroclors with recombinant human, rainbow trout (Onchorhynkiss mykiss), and green anole (Anolis carolinensis) estrogen receptors, using a semi-high throughput competitive binding assay. Toxicological Sciences 2000;53(2):326-339. R826301 (1999)
R826301 (Final)
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Journal Article Matthews J, Celius T, Halgren R, Zacharewski T. Differential estrogen receptor binding of estrogenic substances: a species comparison. Journal of Steroid Biochemistry and Molecular Biology 2000;74(4):223-234. R826301 (2001)
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Journal Article Rosen G, O'Bryant E, Matthews J, Zacharewski T, Wade J. Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard. Journal of Neuroendocrinology 2002;14(1):19-28. R826301 (2001)
R826301 (Final)
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Presentation Celius T, Matthews JB, Villalobos SA, Giesy JP, Zacharewski TR. Cloning of zona radiata proteins from rainbow trout (Oncorhynchus mykiss), a marker for investigating estrogenic endocrine modulators in fish. Presented to the European Society of Environmental Toxicology and Chemistry, England, May 21-25, 2000. R826301 (1999)
R826301 (2000)
R826301 (Final)
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Presentation Celius T, Matthews JB, Giesy J, Zacharewski TR. Cloning of zona radiata proteins from rainbow trout (Oncorhynchus mykiss): a marker for investigating estrogenic endocrine modulators in fish. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. R826301 (1999)
R826301 (2000)
R826301 (Final)
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Presentation Clemons JC, Matthews JB, Zacharewski TR. Development of a rainbow trout recombinant receptor reporter gene bioassay to screen for potential estrogenicity of environmental contaminants in fish. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 15, 1999. R826301 (1999)
R826301 (Final)
not available
Presentation Fertuck KC, Matthews JB, Zacharewski TR. Comparison of in vitro binding and gene expression of benzo[a]pyrene and two hydroxylated benzo[a]pyrene metabolites mediated through estrogen receptors a and b. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. R826301 (1999)
R826301 (2000)
R826301 (Final)
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Presentation Fertuck KC, Matthews JB, Clemons JC, Fielden MR, Zacharewski TR. Estrogen receptor-mediated activities of benzo[a]pyrene: receptor binding, induction of gene expression and uterotrophic effects. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 15, 1999. R826301 (1999)
R826301 (Final)
not available
Presentation Fertuck KC, Sikka H, Matthews JB, Zacharewski TR. Preferential interaction of polyaromatic hydrocarbons (PAH)-related compounds with the beta isoform of the estrogen receptor. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. R826301 (2001)
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Presentation Huang YW, Matthews JB, Zacharewski T. Establishment of Xenophus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. R826301 (2000)
not available
Presentation Huang Y-W, Matthews JB, Zacharewski TR. Establishment of Xenopus leavis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. R826301 (1999)
R826301 (Final)
not available
Presentation Matthews JB, Zacharewski T. Comparison of the interactions of Bisphenol A and its metabolite, Bisphenol A glucuronide with estrogen receptor a and a. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. R826301 (2000)
not available
Presentation Matthews JB, Celius T, Halgren R, Zacharewski TR. Differential estrogen receptor binding of estrogenic substances: a species comparison. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. R826301 (1999)
R826301 (2000)
R826301 (Final)
not available
Presentation Matthews JB, Zacharewski T. Examination of the differential binding affinities polychlorinated biphenyls (PCBs), pentachloro-4-biphenyls (HO-PCBs) and Aroclors with recombinant human, rainbow trout (Onchorhynchus mykiss) and reptilian (Anolis carolinensis) estrogen receptors. Presented at the polychlorinated biphenyl (PCB) Workshop 2000, Lexington, KY, April 10-11, 2000. R826301 (2000)
not available
Presentation Matthews JB, Zacharewski T. Identification of residues within human estrogen receptor-alpha (Era) and rainbow trout ER that are important for interaction with estrogenic compounds: new dimensions in the regulation of gene expression. Presented at the Federation of European Biochemical Societies (FEBS) 2000 Summer School, Island of Spetses, Greece, August 22-29, 2000. R826301 (2000)
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Presentation Matthews JB, Zacharewski TR. Identification of residues within human estrogen receptor-alpha (hERa) and rainbow trout estrogen receptor (rtER) that contribute to temperature sensitivity and interaction with estrogenic compounds. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. R826301 (2001)
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Presentation Matthews JB, Zacharewski TR. Molecular cloning of the reptilian, Anolis carolinensis, estrogen receptor ligand binding domain: comparative amino acid sequence analysis to known estrogen receptors. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 16, 1999. R826301 (1999)
R826301 (Final)
not available
Presentation Matthews JB, Zacharewski TR. PCBs exhibit differential binding to recombinant human alpha and rainbow trout estrogen receptors. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 18, 1999. R826301 (1999)
R826301 (Final)
not available
Presentation Rosen G, Matthews JB, Zacharewski T, Wade J. Distribution of androgen receptor messenger ribonucleic acid (mRNA) in the green anole brain. Presented to the Society of Neuroscience, New Orleans, LA, November 4-9, 2000. R826301 (2000)
not available
Presentation Zacharewski TR, Matthews JB, Celius T, Fertuck K, Huang YW. Differential interactions of estrogenic chemicals with estrogen receptors from several different species. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. R826301 (2001)
not available
Presentation Zacharewski TR. In silico, in vitro, and in vivo assessment of estrogenic endocrine disruptors. Presented at the National Science Foundation Summer Student Program, Department of Biochemistry, Michigan State University Cancer Center, East Lansing, MI, June 29, 1999. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski TR. In vitro assays for assessing endocrine disruptors. Presented at the Pittsburgh Conference & Exposition on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 16, 2000. R826301 (1999)
R826301 (2000)
R826301 (Final)
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Presentation Zacharewski TR. In vitro assessment of estrogenic endocrine disruptors. Presented at the Society of Environmental Toxicology and Chemistry 20th Annual Meeting, Philadelphia, PA, November 17, 1999. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski TR. Molecular basis for endocrine disruptor-estrogen receptor interactions: a species comparison. Presented at the Second Annual Endocrine Disruptors Conference, Seoul, Korea, November 24, 1999. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski TR. Molecular basis of endocrine disruptor-estrogen receptor interaction: a species comparison. Presented at the Toxicology Students' Association-University of Guelph, Guelph, Ontario, March 4, 2000. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski TR. Molecular basis of endocrine disruptor-estrogen receptor interactions. Presented at the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charlotte, SC, February 10, 2000. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski TR. The molecular basis of endocrine disruptor-estrogen receptor interactions: across species comparison. Presented to the Great Lakes Center and the Environmental Health Sciences Graduate Group, School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY, July 13, 1999. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski T. Application of new technologies and implications for risk assessment. Presented at the U.S. Environmental Protection Agency Regional Workshop on Endocrine Disruptors, EPA Region 4, Atlanta, GA, May 1-3, 2001. R826301 (2001)
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Assessment of estrogenic endocrine disruptors: estrogen receptor interactions, toxicogenomics and male reproductive toxicity. Presented to the Curagen Corporation, New Haven, CT, August 7, 2001. R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Endocrine disruption as related to our food supply. The Science of Pre-Harvest Food Safety-Bringing Sound Science to the Table. Presented at the Kellogg Hotel and Conference Center, Michigan State University, E. Lansing, MI, May 8-10, 2001. R826301 (2001)
R827402 (2001)
R827402 (Final)
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Presentation Zacharewski T. Endocrine disruptor-estrogen receptor interactions: the molecular basis for differential activity between species. Presented to the Institute of Cellular and Molecular Biosciences, University of Tokyo, Tokyo, Japan, January 30, 2002. R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Endocrine disruptor-estrogen receptor interactions: the molecular basis for differential activity between species. Presented to the National Institute of Health Sciences, Tokyo, Japan, January 28, 2002. R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Integrating toxicogenomics into predictive and mechanistic toxicology. Presented at the Lorne Genome Conference, Lorne, Australia, February 16-20, 2003. R826301 (2001)
R827402 (Final)
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Presentation Zacharewski T. Molecular basis for endocrine disruptor-estrogen receptor interactions: a species comparison. Presented at the National Institute of Health Sciences, Tokyo, Japan, December 13, 1999. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski T. Molecular basis of endocrine disruptor-estrogen receptor interactions. Presented at the Medical University of South Carolina, Department of Biochemistry and Molecular Biology, Charlotte, SC, February 10, 2000. R826301 (2000)
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Presentation Zacharewski T. Prioritization and screening of estrogenic endocrine disruptors using in vitro and in silico approaches. Presented at the Japanese Environment Agency's Endocrine Disruptor Conference, Kobe, Japan, December 9, 1999. R826301 (1999)
R826301 (Final)
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Presentation Zacharewski T. The molecular basis for endocrine disruptor-estrogen receptor interactions: a species comparison. Presented to the Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY, February 21, 2002. R826301 (2001)
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Presentation Zacharewski T. The molecular basis of endocrine disruptor interaction differences between human and rainbow trout estrogen receptors. Presented at the 8th Annual Mount Desert Island Biological Laboratory (MDIBL) Environmental Health Sciences Symposium-Intracellular Sensors of Environmental Chemicals, Maren Conference Center, Mount Desert Island Biological Laboratory, Salabury Cove, ME, July 11-12, 2001. R826301 (2001)
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Presentation Zacharewski T. Toxicogenomic approaches to assess endocrine disruptors. Presented to the National Institute of Health Sciences, Tokyo, Japan, January 29, 2002. R826301 (2001)
R827402 (Final)
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Presentation Zacharewski, T. Toxicogenomic assessment of endocrine disruptors. Presented at the International Symposium on Environmental Endocrine Disruptors 2001, Tsukuba, Japan, December 15-17, 2001. R826301 (2001)
R827402 (Final)
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Presentation Zacharewski, T. Toxicogenomic assessment strategies for estrogenic endocrine disruptors. Presented to the National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, June 5, 2002. R826301 (2001)
R827402 (Final)
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Symposium Zacharewski T. Assessment of estrogenic endocrine disruptors using global gene expression approaches. Scientific Committee on Problems of the Environment/International Union of Pure and Applied Chemistry-International Symposium on Endocrine Active Substances,Yokohama, Japan, November 17-21, 2002. R826301 (2001)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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