Research Grants/Fellowships/SBIR

Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health

EPA Grant Number: R833293C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R833293
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Southern Center on Environmentally Driven Disparities in Birth Outcomes
Center Director: Miranda , Marie Lynn
Title: Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
Investigators: Auten, Richard , Foster, W. Michael
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text |  Recipients Lists
Research Category: Health Effects , Children's Health , Health

Description:

Objective:

  1. To determine whether maternal exposure to airborne particulates (PM) and/or ozone (1st hit) restricts fetal growth and/or postnatal growth, and impairs lung development/function in newborn mice;
  2. To determine whether PM and/or ozone exposure ‘re-programs’ maternal inflammatory responses;
  3. To determine whether postnatal (2nd hit) ozone exposure further impairs postnatal somatic and lung development/function following maternal PM and/or ozone exposures;
  4. To determine whether genetic or developmental susceptibility to airway hyperreactivity exacerbates maternal and/or postnatal exposure effects on postnatal somatic and lung development/function.

Publications and Presentations:

Publications have been submitted on this subproject: View all 20 publications for this subprojectView all 162 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 8 journal articles for this subprojectView all 75 journal articles for this center

Supplemental Keywords:

Airway hyperreactivity, diesel exhaust particles, air pollution, lung function,

Progress and Final Reports:
2009 Progress Report
2010 Progress Report
2011 Progress Report
Final Report


Main Center Abstract and Reports:
R833293    Southern Center on Environmentally Driven Disparities in Birth Outcomes

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core