Research Grants/Fellowships/SBIR

Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes

EPA Grant Number: R833293C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R833293
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Southern Center on Environmentally Driven Disparities in Birth Outcomes
Center Director: Miranda , Marie Lynn
Title: Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
Investigators: Williams, Redford , Ashley-Koch, Allison , Auten, Richard , Maxson, Pamela , Miranda , Marie Lynn , Reiter, Jerome , Swamy, Geeta
Current Investigators: Williams, Redford , Ashley-Koch, Allison , Gibson-Davis, Christina , Maxson, Pamela , Miranda , Marie Lynn , Reiter, Jerome , Swamy, Geeta
Institution: Duke University
EPA Project Officer: Callan, Richard
Project Period: May 1, 2007 through April 30, 2012 (Extended to April 30, 2014)
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health

Description:

Objective:

The central objective of the Healthy Pregnancy, Healthy Baby Study is to determine how the interaction of environmental, social, and host factors contributes to disparities in birth outcomes between African-American and white women in the American South. There are four specific aims:

  1. Conduct a cohort study of pregnant women in Durham, NC designed to correlate birth weight, gestation, and birth weight x gestation with environmental, social, and host factors;
  2. Develop community-level measures of environmental and social factors by inventorying neighborhood quality and the built environment in partnership with local community groups;
  3. Create a comprehensive data architecture, spatially resolved at the tax parcel level, of environmental, social, and host factors affecting pregnant women by linking data from the cohort study and neighborhood assessments with additional environmental and socioeconomic data; and
  4. Determine whether and to what extent differential exposures explain health disparities in birth outcomes by applying innovative spatial and genetic statistical methods to:
    1. Identify environmental, social, and host factors that cluster to predict birth outcomes in the entire sample,
    2. Determine whether these clusters are more or less present in African-American versus white populations and quantify the proportion of health disparities explained by differences in cluster frequency, and
    3. Identify environmental, social, and host factors that cluster to predict birth outcomes within the African-American and white sub-samples and compare these clusters across racial groups.

Publications and Presentations:

Publications have been submitted on this subproject: View all 51 publications for this subprojectView all 162 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 26 journal articles for this subprojectView all 75 journal articles for this center

Supplemental Keywords:

Pregnancy, preterm birth, low birth weight, racial disparity, African American, environmental stressors, gene-environment interactions, psychosocial stressors, genes, single nucleotide polymorphisms, genetic admixture,

Progress and Final Reports:
2009 Progress Report
2010 Progress Report
2011 Progress Report
Final Report


Main Center Abstract and Reports:
R833293    Southern Center on Environmentally Driven Disparities in Birth Outcomes

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R833293C001 Research Project A: Mapping Disparities in Birth Outcomes
R833293C002 Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes
R833293C003 Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health
R833293C004 Community Outreach and Translation Core
R833293C005 Geographic Information System and Statistical Analysis Core