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Extramural Research

University of Washington Center for Clean Air Research (UW CCAR)

EPA Grant Number: R834796
Center: University of Washington Center for Clean Air Research
Center Director: Vedal, Sverre
Title: University of Washington Center for Clean Air Research (UW CCAR)
Investigators: Vedal, Sverre
Institution: University of Washington , Lovelace Respiratory Research Institute , University of New Mexico , Washington State University
EPA Project Officer: Peffers, Mel
Project Period: December 1, 2010 through November 30, 2015
Project Amount: $8,000,000
RFA: Clean Air Research Centers (2009)
Research Category: Health Effects

Description:

Objective:

The UW CCAR is focused on the cardiovascular health effects of near-roadway pollution, a complex mixture of particle, vapor and gas phase components that vary by vehicle emission source, road surface, extent of physical aging and the type and degree of atmospheric processing and photochemical reactions. This exposure scenario is not only known to be of considerable health importance, it also serves as a prototypical case for developing research approaches to dealing with multi-pollutant exposure-effect relationships. Our aim is to integrate exposure, epidemiological, toxicological, clinical, and statistical sciences to study cardiovascular hazards of fresh and aged roadway emissions and significantly advance our understanding of the components and reaction products that cause these effects.

Approach:

Investigators from four institutions are joining in a multi-disciplinary effort to study health effects of near-roadway pollution in line with current efforts to move from a single-pollutant to a multi-pollutant perspective. The Center consists of five highly-integrated research projects and two facility cores (including a Biostatistics Core) that together have the following six tasks: (1) to characterize real-world near-roadway pollutant concentrations, particle size distributions and chemical composition; (2) to simulate realistic contrasting near-roadway multi-pollutant exposure atmospheres for laboratory animal and human studies; (3) to identify cardiovascular and immunologic effects and the pathogenic mechanisms of near-roadway exposures using animal models; (4) to identify cardiovascular and immunologic effects of near-roadway exposures in human clinical studies; (5) to identify effects of long-term exposure to traffic-derived particles and gases on sub-clinical measures of cardiovascular disease and DNA methylation in a multi-ethnic population; and (6) to develop a statistical and methodological framework for studying health effects of multi-pollutant mixtures.

Expected Results:

The Center program of research addresses at least three of the research questions posed in the RFA: (1) pollutant health effects in a multi-pollutant context; (2) biological mechanisms underlying health effects; and (3) exposure-response relationships. Identifying the most hazardous components of near-roadway exposures will allow more focused, coordinated and effective air pollution health policy based on sound science to reduce health impacts of this multi-pollutant exposure.


Journal Articles: 16 Displayed | Download in RIS Format

Other center views: All 34 publications 16 publications in selected types All 16 journal articles

Type Citation Sub Project Document Sources
Journal Article Bergen S, Sheppard L, Sampson PD, Kim SY, Richards M, Vedal S, Kaufman JD, Szpiro AA. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environmental Health Perspectives 2013;121(9):1017-1025.
abstract available   full text available
R834796 (2013)
R834796C005 (2013)
R833864 (2011)
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  • Full-text: Environmental Health Perspectives-Full Text HTML
  • Journal Article Campen MJ, Lund A, Rosenfeld M. Mechanisms linking traffic-related air pollution and atherosclerosis. Current Opinion in Pulmonary Medicine 2012;18(2):155-160.
    abstract available  
    R834796 (2012)
    R834796 (2013)
    R834796C003 (2012)
    R834796C003 (2013)
    R833990 (2010)
    R833990 (2011)
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  • Journal Article Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Technology Discussions 2013;6:6005-6046.
    abstract available  
    R834796 (2013)
    R834796C001 (2013)
  • Abstract: Atmospheric Measurement Techniques - Abstract
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  • Journal Article Lindstrom J, Szpiro AA, Sampson PD, Oron A, Richards M, Larson TV, Sheppard L. A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates. Environmental and Ecological Statistics 2013 Aug [Epub ahead of print] doi:10.1007/s10651-013-0261-4.
    abstract available  
    R834796 (2013)
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  • Journal Article Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhalation Toxicology 2013;25(6):309-324.
    abstract available  
    R834796 (2013)
    R834796C003 (2013)
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  • Abstract: informa healthcare - abstract
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  • Journal Article McDonald JD, Chow JC, Peccia J, Liu Y, Chand R, Hidy GM, Mauderly JL. Influence of collection region and site type on the composition of paved road dust. Air Quality, Atmosphere & Health 2013;6(3):615-628.
    abstract available  
    R834796 (2013)
    R834796C002 (2013)
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  • Journal Article Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ. CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. Toxicological Sciences 2013;143(2):304-311.
    abstract available  
    R834796 (2013)
    R834796C003 (2013)
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  • Journal Article Sampson PD, Richards M, Szpiro AA, Bergen S, Sheppard L, Larson TV, Kaufman JD. A regionalized national universal kriging model using Partial Least Squares regression for estimating annual PM2.5 concentrations in epidemiology. Atmospheric Environment 2013;75:383-392.
    abstract available   full text available
    R834796 (2013)
    R833864 (2012)
    R833864 (2013)
    R833864 (Final)
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  • Abstract: ScienceDirect-Abstract
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  • Journal Article Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope III CA, Brunekreef B. Confounding and exposure measurement error in air pollution epidemiology. Air Quality, Atmosphere & Health 2012;5(2):203-216.
    abstract available   full text available
    R834796 (2012)
    R834796 (2013)
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  • Journal Article Sun M, Kaufman JD, Kim SY, Larson TV, Gould TR, Polak JF, Budoff MJ, Diez Roux AV, Vedal S. Particulate matter components and subclinical atherosclerosis: common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study. Environmental Health 2013;12:39.
    abstract available   full text available
    R834796 (2013)
    R834796C005 (2013)
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  • Journal Article Szpiro AA, Sheppard L, Lumley T. Efficient measurement error correction with spatially misaligned data. Biostatistics 2011;12(4):610-623.
    abstract available   full text available
    R834796 (2012)
    R834796 (2013)
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  • Full-text: Biostatistics-Full Text HTML
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  • Abstract: Biostatistics-Abstract
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  • Journal Article Szpiro AA, Paciorek CJ, Sheppard L. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology 2011;22(5):680-685.
    abstract available   full text available
    R834796 (2012)
    R834796 (2013)
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  • Journal Article Szpiro AA, Paciorek CJ. Measurement error in two-stage analyses, with application to air pollution epidemiology. Environmetrics 2013;24(8):501-517.
    abstract available   full text available
    R834796 (2013)
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  • Journal Article Szpiro AA, Sheppard L, Adar SD, Kaufman JD. Estimating acute air pollution health effects from cohort study data. Biometrics 2014;70(1):164-174.
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    R834796 (2013)
    R834796C005 (2013)
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  • Journal Article Vedal S, Kaufman JD. What does multi-pollutant air pollution research mean? American Journal of Respiratory and Critical Care Medicine 2011;183(1):4-6.
    abstract available   full text available
    R834796 (2012)
    R834796 (2013)
    R834796C005 (2013)
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  • Journal Article Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA. Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arteriosclerosis, Thrombosis & Vascular Biology 2013;33(6):1153-1161.
    abstract available   full text available
    R834796 (2013)
    R834796C003 (2013)
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  • Full-text: American Heart Associations Journals - full text html
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  • Abstract: American Heart Associations Journals - abstract
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  • Supplemental Keywords:

    atherosclerosis, epidemiology, toxicology, transportation,, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, Environmental Monitoring, Atmospheric Sciences, particulate matter, airway disease, bioavailability, air pollution, particle exposure, ambient particle health effects, vascular dysfunction, cardiotoxicity

    Progress and Final Reports:
    2011 Progress Report
    2012 Progress Report
    2013 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834796C001 Exposure Mapping – Characterization of Gases and Particles for Exposure Assessment in Health Effects and Laboratory Studies
    R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
    R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
    R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
    R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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