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Extramural Research

Multi-Scale Assessment of Health Effects of Air Pollution Mixtures Using Novel Measurements and Models

EPA Grant Number: R834799
Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Multi-Scale Assessment of Health Effects of Air Pollution Mixtures Using Novel Measurements and Models
Investigators: Tolbert, Paige , Russell, Armistead G.
Institution: Emory University , Georgia Institute of Technology
EPA Project Officer: Hunt, Sherri
Project Period: October 1, 2010 through September 30, 2015
Project Amount: $7,999,779
RFA: Clean Air Research Centers (2009)
Research Category: Health Effects

Description:

Objective:

A multi-institutional, multi-disciplinary Center is proposed to address critical issues relating to the public health impacts of ambient air pollution. The overarching theme of the Center is a focus on characterizing ambient air pollution mixtures and elucidating their role in human health risks associated with air pollution. Novel measurements and modeling approaches will be applied in the context of a tiered multi-scale assessment of the health risks of mixtures characterized based on: I) biological considerations (oxidants); 2) environmental management (sources); 3) evidence-based considerations (traffic emissions); 4) empirical assessment (data-based approach).

Approach:

Four Research Projects will be supported by three Cores: an Administrative Core, an Air Quality Core and a Biostatistics Core. Project 1 will develop and deploy instrumentation to measure oxidants (including aerosol reactive oxygen species) and other species of interest to better understand their origins and atmospheric transformation and for use in characterizing mixtures for the three health studies. Project 2 will make direct use of these measurements to confirm associations with markers of oxidative stress in commuters. Projects 3 and 4 will use a combination of measurements and modeled air quality estimates in large population studies, with Project 3 investigating questions regarding risks of in utero and early life exposures to air pollutant mixtures in two major new birth cohorts and Project 4 assessing underlying consistencies in morbidity associations across selected cities that have comprehensive daily air pollution characterization. The health projects include assessment of potentially sensitive and vulnerable subpopulations.

Expected Results:

The Center brings together a productive group of researchers with depth in the relevant disciplines and access to rich air quality and health outcome databases to conduct an integrated and innovative research program. The proposed research program will contribute important new insights regarding all of the primary questions of interest motivating the RFA.


Journal Articles: 44 Displayed | Download in RIS Format

Other center views: All 149 publications 46 publications in selected types All 44 journal articles

Type Citation Sub Project Document Sources
Journal Article Balachandran S, Pachon JE, Hu Y, Lee D, Mulholland JA, Russell AG. Ensemble-trained source apportionment of fine particulate matter and method uncertainty analysis. Atmospheric Environment 2012;61:387-394. R834799 (2012)
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R833866 (Final)
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  • Journal Article Baxter LK, Dionisio KL, Burke J, Sarnat SE, Sarnat JA, Hodas N, Rich DQ, Turpin BJ, Jones RR, Mannshardt E, Kumar N, Beevers SD, Ozkaynak H. Exposure prediction approaches used in air pollution epidemiology studies: key findings and future recommendations. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):654-659. R834799 (2013)
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  • Journal Article Brown MS, Sarnat SE, DeMuth KA, Brown LAS, Whitlock DR, Brown SW, Tolbert PE, Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012;7(5):e37044. R834799 (2012)
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  • Journal Article Chang HH, Reich BJ, Miranda ML. A spatial time-to-event approach for estimating associations between air pollution and preterm birth. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2013;62(2):167-179. R834799 (2013)
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  • Journal Article Darrow LA, Hess J, Rogers CA, Tolbert PE, Klein M, Sarnat SE. Ambient pollen concentrations and emergency department visits for asthma and wheeze. Journal of Allergy and Clinical Immunology 2012;130(3):630-638. R834799 (2012)
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  • Journal Article Flanders WD, Klein M, Darrow LA, Strickland MJ, Sarnat SE, Sarnat JA, Waller LA, Winquist A, Tolbert PE. A method for detection of residual confounding in time-series and other observational studies. Epidemiology 2011;22(1):59-67. R834799 (2013)
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  • Journal Article Flanders WD, Klein M, Darrow LA, Strickland MJ, Sarnat SE, Sarnat JA, Waller LA, Winquist A, Tolbert PE. A method to detect residual confounding in spatial and other observational studies. Epidemiology 2011;22(6):823-826. R834799 (2012)
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  • Journal Article Goldman GT, Mulholland JA, Russell AG, Strickland MJ, Klein M, Waller LA, Tolbert PE. Impact of exposure measurement error in air pollution epidemiology:effect of error type in time-series studies. Environmental Health 2011;10:61. R834799 (2011)
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  • Journal Article Goldman GT, Mulholland JA, Russell AG, Gass K, Strickland MJ, Tolbert PE. Characterization of ambient air pollution measurement error in a time-series health study using a geostatistical simulation approach. Atmospheric Environment 2012;57:101-108. R834799 (2012)
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  • Journal Article Greenwald R, Bergin MH, Yip F, Boehmer T, Kewada P, Shafer MM, Schauer JJ, Sarnat JA. On-roadway in-cabin exposure to particulate matter: measurement results using both continuous and time-integrated sampling approaches. Aerosol Science and Technology 2014;48(6):664-675. R834799 (2014)
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  • Journal Article Hu X, Waller LA, Al-Hamdan MZ, Crosson WL, Estes Jr. MG, Estes SM, Quattrochi DA, Sarnat JA, Liu Y. Estimating ground-level PM2.5 concentrations in the southeastern U.S. using geographically weighted regression. Environmental Research 2013;121:1-10. R834799 (2013)
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  • Journal Article King LE, Weber RJ. Development and testing of an online method to measure ambient fine particulate reactive oxygen species (ROS) based on the 2’,7’-dichlorofluorescin (DCFH) assay. Atmospheric Measurement Techniques 2013;6(7):1647-1658. R834799 (2013)
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  • Journal Article Liu J, Scheuer E, Dibb J, Ziemba LD, Thornhill KL, Anderson BE, Wisthaler A, Mikoviny T, Devi JJ, Bergin M, Weber RJ. Brown carbon in the continental troposphere. Geophysical Research Letters 2014;41(6):2191-2195. R834799 (2014)
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  • Journal Article Maier ML, Balachandran S, Sarnat SE, Turner JR, Mulholland JA, Russell AG. Application of an ensemble-trained source apportionment approach at a site impacted by multiple point sources. Environmental Science & Technology 2013;47(8):3743-3751. R834799 (2013)
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  • Journal Article Neelon B, Chang HH, Ling Q, Hastings NS. Spatiotemporal hurdle models for zero-inflated count data:exploring trends in emergency department visits. Statistical Methods in Medical Research 2014 [Epub ahead of print]. R834799 (2014)
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  • Journal Article Pachon JE, Balachandran S, Hu Y, Mulholland JA, Darrow LA, Sarnat JA, Tolbert PE, Russell AG. Development of outcome-based, multipollutant mobile source indicators. Journal of the Air & Waste Management Association 2012;62(4):431-442. R834799 (2012)
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  • Journal Article Pearce JL, Waller LA, Chang HH, Klein M, Mulholland JA, Sarnat JA, Sarnat SE, Strickland MJ, Tolbert PE. Using self-organizing maps to develop ambient air quality classifications: a time series example. Environmental Health 2014;13(7):56. R834799 (2014)
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  • Journal Article Reich BJ, Chang HH, Strickland MJ. Spatial health effects analysis with uncertain residential locations. Statistical Methods in Medical Research 2014;23(2):156-168. R834799 (2012)
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  • Journal Article Reich BJ, Chang HH, Foley KM. A spectral method for spatial downscaling. Biometrics 2014;70(4):932-942. R834799 (2014)
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  • Journal Article Sarnat JA, Sarnat SE, Flanders WD, Chang HH, Mulholland J, Baxter L, Isakov V, Ozkaynak H. Spatiotemporally resolved air exchange rate as a modifier of acute air pollution-related morbidity in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):606-615. R834799 (2013)
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  • Journal Article Sarnat SE, Sarnat JA, Mulholland J, Isakov V, Ozkaynak H, Chang HH, Klein M, Tolbert PE. Application of alternative spatiotemporal metrics of ambient air pollution exposure in a time-series epidemiological study in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):593-605. R834799 (2013)
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  • Journal Article Strickland MJ, Darrow LA, Mulholland JA, Klein M, Flanders WD, Winquist A, Tolbert PE. Implications of different approaches for characterizing ambient air pollutant concentrations within the urban airshed for time-series studies and health benefits analyses. Environmental Health 2011;10(5):36. R834799 (2011)
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  • Journal Article Strickland MJ, Gass KM, Goldman GT, Mulholland JA. Effects of ambient air pollution measurement error on health effect estimates in time-series studies: a simulation-based analysis. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):160-166. R834799 (2013)
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  • Journal Article Verma V, Rico-Martinez R, Kotra N, King L, Liu J, Snell TW, Weber RJ. Contribution of water-soluble and insoluble components and their hydrophobic/hydrophilic subfractions to the reactive oxygen species-generating potential of fine ambient aerosols. Environmental Science & Technology 2012;46(20):11384-11392. R834799 (2012)
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  • Journal Article Verma V, Rico-Martinez R, Kotra N, Rennolds C, Liu J, Snell TW, Weber RJ. Estimating the toxicity of ambient fine aerosols using freshwater rotifer Brachionus calyciflorus (Rotifera: Monogononta). Environmental Pollution 2013;182:379-384. R834799 (2014)
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  • Journal Article Waller LA. Commentary: regarding assessments of chance in investigations of ‘cluster series.’ International Journal of Epidemiology 2013;42(2):449-452. R834799 (2013)
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  • Journal Article Winquist A, Klein M, Tolbert P, Sarnat SE. Power estimation using simulations for air pollution time-series studies. Environmental Health 2012;11(9):68. R834799 (2012)
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  • Journal Article Winquist A, Klein M, Tolbert P, Flanders WD, Hess J, Sarnat SE. Comparison of emergency department and hospital admissions data for air pollution time-series studies. Environmental Health 2012;11(9):70. R834799 (2012)
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  • Journal Article Winquist A, Kirrane E, Klein M, Strickland M, Darrow LA, Sarnat SE, Gass K, Mulholland J, Russell A, Tolbert P. Joint effects of ambient air pollutants on pediatric asthma emergency department visits in Atlanta, 1998-2004. Epidemiology 2014;25(5):666-673. R834799 (2014)
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  • Journal Article Yu C, Di Girolamo L, Chen L, Zhang X, Liu Y. Statistical evaluation of the feasibility of satellite-retrieved cloud parameters as indicators of PM2.5 levels. Journal of Exposure Science & Environmental Epidemiology July 23, 2014 [Epub ahead of print]. R834799 (2014)
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  • Journal Article Balachandran S, Chang HH, Pachon JE, Holmes HA, Mulholland JA, Russell AG. Bayesian-based ensemble source apportionment of PM2.5. Environmental Science & Technology 2013;47(23):13511-13518. R834799 (2013)
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  • Journal Article Liu J, Bergin M, Guo H, King L, Kotra N, Edgerton E, Weber RJ. Size-resolved measurements of brown carbon in water and methanol extracts and estimates of their contribution to ambient fine-particle light absorption. Atmospheric Chemistry and Physics 2013;13(24):12389-12404. R834799 (2014)
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  • Journal Article Pachon JE, Weber RJ, Zhang X, Mulholland JA, Russell AG. Revising the use of potassium (K) in the source apportionment of PM2.5. Atmospheric Pollution Research 2013;4(1):14-21. R834799 (2013)
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  • Journal Article Dionisio KL, Isakov V, Baxter LK, Sarnat JA, Sarnat SE, Burke J, Rosenbaum A, Graham SE, Cook R, Mulholland J, Ozkaynak H. Development and evaluation of alternative approaches for exposure assessment of multiple air pollutants in Atlanta, Georgia. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):581-592. R834799 (2013)
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  • Journal Article Sarnat JA, Golan R, Greenwald R, Raysoni AU, Kewada P, Winquist A, Sarnat SE, Flanders WD, Mirabelli MC, Zora JE, Bergin MH, Yip F. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environmental Research 2014;133:66-76. R834799 (2014)
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  • Journal Article Hu X, Waller LA, Lyapustin A, Wang Y, Al-Hamdan MZ, Crosson WL, Estes Jr. MG, Estes SM, Quattrochi DA, Puttaswamy SJ, Liu Y. Estimating ground-level PM2.5 concentrations in the Southeastern United States using MAIAC AOD retrievals and a two-stage model. Remote Sensing of Environment 2014;140:220-232. R834799 (2013)
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  • Journal Article Ma Z, Hu X, Huang L, Bi J, Liu Y. Estimating ground-level PM2.5 in China using satellite remote sensing. Environmental Science & Technology 2014;48(13):7436-7444. R834799 (2014)
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  • Journal Article Chang HH, Hu X, Liu Y. Calibrating MODIS aerosol optical depth for predicting daily PM2.5 concentrations via statistical downscaling. Journal of Exposure Science & Environmental Epidemiology 2014;24(4):398-404. R834799 (2013)
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  • Journal Article Hu X, Waller LA, Lyapustin A, Wang Y, Liu Y. 10-year spatial and temporal trends of PM2.5 concentrations in the southeastern US estimated using high-resolution satellite data. Atmospheric Chemistry and Physics 2014;14(12):6301-6314. R834799 (2014)
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  • Journal Article Chang HH, Hao H, Sarnat SE. A statistical modeling framework for projecting future ambient ozone and its health impact due to climate change. Atmospheric Environment 2014;89:290-297. R834799 (2014)
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  • Journal Article Gass K, Klein M, Chang HH, Flanders WD, Strickland MJ. Classification and regression trees for epidemiologic research: an air pollution example. Environmental Health 2014;13:17. R834799 (2013)
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  • Journal Article Dionisio KL, Baxter LK, Chang HH. An empirical assessment of exposure measurement error and effect attenuation in bipollutant epidemiologic models. Environmental Health Perspectives 2014;122(11):1216-1224. R834799 (2014)
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  • Journal Article Strickland MJ, Klein M, Flanders WD, Chang HH, Mulholland JA, Tolbert PE, Darrow LA. Modification of the effect of ambient air pollution on pediatric asthma emergency visits: susceptible subpopulations. Epidemiology 2014;25(6):843-850. R834799 (2014)
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  • Journal Article Winquist A, Schauer JJ, Turner JR, Klein M, Sarnat SE. Impact of ambient fine particulate matter carbon measurement methods on observed associations with acute cardiorespiratory morbidity. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):215-221. R834799 (2014)
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  • Supplemental Keywords:

    ambient air, atmosphere, health effects, human health, susceptibility, vulnerability, sensitive populations, infants, children, risk, dose-response, cumulative effects, epidemiology, exposure, public policy, air quality modeling, monitoring, measurement methods, aerosol, particulates, PM2.5, organics, elemental carbon, metals, ozone, oxidants, PAH, sulfates, source characterization, mobile sources, Georgia, GA, Southeast,, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, particulate matter, children's health, ambient air monitoring, climate change, air pollution, ambient particle health effects, airshed modeling, human health risk

    Progress and Final Reports:
    2011 Progress Report
    2012 Progress Report
    2013 Progress Report
    2014 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
    R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
    R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
    R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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