Grantee Research Project Results
(Pilot Study): Predictors of Maternal Exposure to BPA During PregnancyEPA Grant Number: R834678C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834678
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Children's Environmental Health and Disease Prevention Research Center: Formative Center - University of California, San Francisco
Center Director: Woodruff, Tracey J.
Title: (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy
Investigators: Stotland, Naomi
Institution: University of California - San Francisco
EPA Project Officer: Louie, Nica
Project Period: May 1, 2010 through April 30, 2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009)
Research Category: Children's Health
Large national biomonitoring studies are reporting nearly universal exposure to numerous environmental contaminants in the US population, including Bisphenol A (BPA), raising the question of how exactly people are being exposed. Identifying the actual sources of exposure to chemicals that are ubiquitous in our environment is fundamental to the development of strategies and policies that will effectively reduce and prevent harmful exposures. Our understanding of human contact with environmental sources of exposure is inadequately characterized and thus we do not know which sources or behaviors are producing the chemical body burden that we discover through biomonitoring studies. This pilot study is designed to provide research on potential sources of exposure to BPA, to understand more about the biological half-life of BPA and to provide critical insights into potential sources of intrauterine exposure to BPA. To achieve these aims, we will develop and implement a questionnaire on dietary intake of potentially BPA contaminated foods and beverages. We will analyze the relationship between questionnaire data and levels of BPA measured in maternal blood and urine from pregnant women to identify key sources of exposure. We will also explore and account for previously reported relationships between BPA exposure and such socio-demographic factors as age, ethnicity and socio-economic status. We will compare levels of BPA in maternal specimens collected during non-fasting and fasting conditions to characterize the clearance and biological half life of BPA in pregnant women.Expected Results:
This study addresses data gaps in our knowledge of how humans are exposed to BPA - a key piece of information for reducing and preventing exposures. It will also provide valuable insight regarding the biological half-life of BPA. This information will contribute to efforts toward prevention of exposures and will contribute new tools to future epidemiologic studies.Supplemental Keywords:
risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, Biochemistry, Children's Health, Environmental Policy, Biology, prenatal exposure, developmental toxicity, biological response, chemical mixtures, children's vulnerablity, assessment of exposure, children's environmental health
Main Center Abstract and Reports:
R834678 Children's Environmental Health and Disease Prevention Research Center: Formative Center - University of California, San Francisco
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy