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Extramural Research

The Columbia Center for Children’s Environmental Health

EPA Grant Number: R834509
Center: The Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: The Columbia Center for Children’s Environmental Health
Investigators: Perera, Frederica P. , Andrews, Howard F. , Champagne, Frances , Evans, David , Freyer, Greg , Garfinkel, Robin S. , Miller, Rachel L. , Moore, Holly , Oberfield, Sharon , Peterson, Brad , Rauh, Virginia , Rundle, Andrew , Shepard, Peggy , Tang, Deliang , Whyatt, Robin M.
Current Investigators: Perera, Frederica P. , Champagne, Frances , Evans, David , Miller, Rachel L. , Rauh, Virginia , Rundle, Andrew , Shepard, Peggy , Whyatt, Robin M.
Institution: Columbia University in the City of New York
EPA Project Officer: Callan, Richard
Project Period: September 24, 2009 through September 23, 2014 (Extended to September 23, 2015)
Project Amount: $3,953,320
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009)
Research Category: Children's Health

Description:

Objective:

The research theme of the Columbia Center for Children’s Environmental Health (CCCEH) is the role of endocrine (hormone system) disruptors, polycyclic aromatic hydrocarbons (PAH) in air pollution and bisphenol A (BPA), in the development of obesity, metabolic syndrome, and neurodevelopmental disorders in children. Consistent with the goals of EPA and NIEHS, we are conducting three closely linked research projects focused on elucidating the mechanisms by which prenatal and postnatal exposure to PAH and BPA may contribute to these disorders, as expressed in early adolescence and the period just before and after puberty. Our overall hypothesis is that early exposures to these endocrine disruptors are risk factors for the development of potentially serious health problems and that epigenetic mechanisms (heritable changes in gene expression or phenotype caused by mechanisms other than changes in the DNA sequence) are involved in mediating their effects. Continuing our partnership with WE ACT for Environmental Justice, and adding a Pediatric Health Specialist to our team, we will communicate our scientific findings to the participating families, at-risk communities, clinicians, and policymakers so that preventive measures can be taken to protect vulnerable children living in urban areas.

Approach:

The Center is using molecular epidemiologic approaches as it tracks a longitudinal birth cohort of African-American and Dominican children in Northern Manhattan and the South Bronx. Project 1, The Role of Endocrine Disruptors in Childhood Obesity, is designed to assess whether exposures to BPA and PAHs during pregnancy and early childhood are associated with obesity and metabolic syndrome among children during early adolescence. Project 2, The Role of Endocrine Disruptors in Neurodevelopmental Disorders, will assess whether prenatal exposure to the same endocrine disruptors, PAHs and BPA, is associated with adverse neurobehavioral effects among children in the years just before and after puberty. Both Projects 1 and 2 will evaluate the role of exposure-related changes in epigenetics/gene expression in mediating these health effects. Project 3, The Mechanisms of Endocrine Disruptors in Laboratory Mice, will determine the mechanisms by which prenatal PAHs (inhaled) and BPA (oral) exposure affect child obesity and neurobehavioral development by elucidating the associated molecular changes in DNA methylation and gene expression. The research projects are supported by three cores: Core 1, CCCEH Administration (Admin); Core 2, Data Management, and Statistics (DMS); and Core 3, Community Outreach and Translation (COTC).

Expected Results:

If the aims of our program are achieved, we will have generated needed information on the risks of prenatal and postnatal PAH exposure for obesity and metabolic disorder in early adolescence, as well as a better understanding of the longer-term consequences of prenatal PAH exposure on behavioral and cognitive function. We will also have characterized risks of prenatal and early postnatal exposure to BPA. In addition, we will have gained a more nuanced understanding of the molecular mechanisms involved in toxicity of these common environmental pollutants. Appropriately , all of this information will be a powerful tool in prevention: First, by informing parents and caregivers of risks and ways to reduce exposures; second, by informing clinicians and health care providers of risks so that they can educate their patients; and third, by informing policymakers in decision making about disease prevention.


Journal Articles: 34 Displayed | Download in RIS Format

Other center views: All 58 publications 36 publications in selected types All 34 journal articles

Type Citation Sub Project Document Sources
Journal Article Choi H, Perera FP. Sources of greater fetal vulnerability to airborne polycyclic aromatic hydrocarbons among African Americans. Journal of Epidemiology and Community Health 2012;66(2):121-126. R834509 (2014)
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  • Journal Article Choi H, Wang L, Lin X, Spengler JD, Perera FP. Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction. PLoS One 2012;7(4):e35464. R834509 (2014)
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  • Journal Article Herbstman JB, Tang D, Zhu D, Qu L, Sjodin A, Li Z, Camann D, Perera FP. Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord blood. Environmental Health Perspectives 2012;120(5):733-738. R834509 (2012)
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  • Journal Article Herbstman JB, Wang S, Perera FP, Lederman SA, Vishnevetsky J, Rundle AG, Hoepner LA, Qu L, Tang D. Predictors and consequences of global DNA methylation in cord blood and at three years. PLoS One 2013;8(9):e72824. R834509 (2014)
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  • Journal Article Hoepner LA, Whyatt RM, Just AC, Calafat AM, Perera FP, Rundle AG. Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years. Environmental Research 2013;122:38-44. R834509 (2012)
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  • Journal Article Iyer S, Perera F, Zhang B, Chanock S, Wang S, Tang D. Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns. Carcinogenesis 2014;35(1):69-75. R834509 (2014)
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  • Journal Article Jung KH, Bernabé K, Moors K, Yan B, Chillrud SN, Whyatt R, Camann D, Kinney PL, Perera FP, Miller RL. Effects of floor level and building type on residential levels of outdoor and indoor polycyclic aromatic hydrocarbons, black carbon, and particulate matter in New York City. Atmosphere 2011;2(2):96-109. R834509 (2014)
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  • Journal Article Jung KH, Perzanowski M, Rundle A, Moors K, Yan B, Chillrud SN, Whyatt R, Camann D, Perera FP, Miller RL. Polycyclic aromatic hydrocarbon exposure, obesity and childhood asthma in an urban cohort. Environmental Research 2014;128:35-41. R834509 (2014)
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  • Journal Article Jung KH, Liu B, Lovinsky-Desir S, Yan B, Camann D, Sjodin A, Li Z, Perera F, Kinney P, Chillrud S, Miller RL. Time trends of polycyclic aromatic hydrocarbon exposure in New York City from 2001 to 2012: assessed by repeat air and urine samples. Environmental Research 2014;131:131:95-103. R834509 (2014)
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  • Journal Article Kundakovic M, Champagne FA. Epigenetic perspective on the developmental effects of bisphenol A. Brain, Behavior, and Immunity 2011;25(6):1084-1093. R834509 (2012)
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  • Journal Article Kundakovic M, Gudsnuk K, Franks B, Madrid J, Miller RL, Perera FP, Champagne FA. Sex-specific epigenetic disruption and behavioral changes following low dose in utero bisphenol A exposure. Proceedings of the National Academy of Sciences USA 2013;110(24):9956-9961. R834509 (2014)
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  • Journal Article Kundakovic M, Gudsnuk A, Herbstman JB, Tang D, Perera, Champagne FA. DNA methylation of BDNF as a biomarker of early-life adversity. Proceedings of the National Academy of Sciences USA 2015;112(22):6807–6813. R834509 (2014)
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  • Journal Article Lovasi GS, Eldred-Skemp N, Quinn JW, Chang HW, Rauh VA, Rundle A, Orjuela MA, Perera FP. Neighborhood social context and individual polycyclic aromatic hydrocarbon exposures associated with child cognitive test scores. Journal of Child and Family Studies 2014;23(5):785-799. R834509 (2014)
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  • Journal Article Lovinsky-Desir S, Miller RL. Epigenetics, asthma, and allergic diseases: a review of latest advancements. Current Allergy and Asthma Reports 2012;12(3):211-220. R834509 (2012)
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  • Journal Article Mueller NT, Whyatt R, Hoepner L, Oberfield S, Dominguez-Bello MG, Widen EM, Hassoun A, Perera F, Rundle A. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. International Journal of Obesity 2015;39(4):665-670. R834509 (2014)
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  • Journal Article Orjuela MA, Liu X, Warburton D, Siebert AL, Cujar C, Tang D, Jobanputra V, Perera FP. Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood. Mutation Research 2010;703(2):108-114. R834509 (2014)
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  • Journal Article Orjuela MA, Liu X, Miller RL, Warburton D, Tang D, Jobanputra V, Hoepner L, Suen IH, Diaz-Carreño S, Li Z, Sjodin A, Perera FP. Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children. Cancer Epidemiology, Biomarkers & Prevention 2012;21(7):1191-1202. R834509 (2014)
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  • Journal Article Perera FP, Li Z, Whyatt R, Hoepner L, Wang S, Camann D, Rauh V. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics 2009;124(2):e195-e202. R834509 (2014)
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  • Journal Article Perera FP, Wang S, Vishnevetsky J, Zhang B, Cole KJ, Tang D, Rauh V, Phillips DH. Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York City children. Environmental Health Perspectives 2011;119(8):1176-1181. R834509 (2014)
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  • Journal Article Perera FP, Tang D, Wang S, Vishnevetsky J, Zhang B, Diaz D, Camann D, Rauh V. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environmental Health Perspectives 2012;120(6):921-926. R834509 (2012)
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  • Journal Article Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, Huang TJ, Miller RL, Wang S, Rauh V. Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One 2014;9(11):e111670. R834509 (2014)
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  • Journal Article Perera F, Herbstman J. Prenatal environmental exposures, epigenetics, and disease. Reproductive Toxicology 2011;31(3):363-373. R834509 (2014)
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  • Journal Article Perera F, Vishnevetsky J, Herbstman JB, Calafat AM, Xiong W, Rauh V, Wang S. Prenatal bisphenol A exposure and child behavior in an inner-city cohort. Environmental Health Perspectives 2012;120(8):1190-1194. R834509 (2012)
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  • Journal Article Perera F, Weiland K, Neidell M, Wang S. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and IQ: estimated benefit of pollution reduction. Journal of Public Health Policy 2014;35(3):327-336. R834509 (2014)
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  • Journal Article Rauh VA, Horton MK, Miller RL, Whyatt RM, Perera F. Neonatology and the environment:early exposure to airborne environmental toxicants. Neoreviews 2010;11(7):363-369. R834509 (2012)
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  • Journal Article Rundle A, Hoepner L, Hassoun A, Oberfield S, Freyer G, Holmes D, Reyes M, Quinn J, Camann D, Perera F, Whyatt R. Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy. American Journal of Epidemiology 2012;175(11):1163-1172. R834509 (2012)
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  • Journal Article Tang WY, Levin L, Talaska G, Cheung YY, Herbstman J, Tang D, Miller RL, Perera F, Ho SM. Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells. Environmental Health Perspectives 2012;120(8):1195-1200. R834509 (2012)
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  • Journal Article Vishnevetsky J, Tang D, Chang HW, Roen EL, Wang Y, Rauh V, Wang S, Miller RL, Herbstman J, Perera FP. Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ. Neurotoxicology and Teratology 2015;49:74-80. R834509 (2014)
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  • Journal Article Wang S, Chanock S, Tang D, Li Z, Edwards S, Jedrychowski W, Perera FP. Effect of gene-environment interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. Annals of Human Genetics 2010;74(1):46-56. R834509 (2014)
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  • Journal Article Wang S, Yu Z, Miller RL, Tang D, Perera FP. Methods for detecting interactions between imprinted genes and environmental exposures using birth cohort designs with mother-offspring pairs. Human Heredity 2011;71(3):196-208. R834509 (2014)
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  • Journal Article Wang S, Xiong W, Ma W, Chanock S, Jedrychowski W, Wu R, Perera FP. Gene-environment interactions on growth trajectories. Genetic Epidemiology 2012;36(3):206-213. R834509 (2012)
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  • Journal Article Weiland K, Neidell M, Rauh V, Perera F. Cost of developmental delay from prenatal exposure to airborne polycyclic aromatic hydrocarbons. Journal of Health Care for the Poor and Underserved 2011;22(1):320-329. R834509 (2014)
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  • Journal Article Witherspoon NO, Trousdale K, Bearer CF, Miller RL. The public health and policy implications of epigenetics and pediatric health research. Environmental Health Perspectives 2012;120(10):a380-a381. R834509 (2012)
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  • Journal Article Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L, McDonald JD, Yan B, Schwartz GJ, Miller RL. Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR) γ methylation in offspring, grand-offspring mice. PLoS One 2014;9(10):e110706. R834509 (2014)
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  • Supplemental Keywords:

    Ambient air, human health, toxic, public policy, community-based, ethnic groups, susceptibility, epidemiology, Northeast, pollutants/toxics, environmental management, scientific discipline, health, biology, Chemicals, Children's Health, Biochemistry, Environmental Policy, exposure assessment, health effects, children's environmental health,childhood obesity, assessment of exposure, endocrine disruptors, developmental neurotoxicity ,air toxics,air pollution,growth and development,children's vulnerablity

    Relevant Websites:

    http://www.ccceh.org Exit

     

    Progress and Final Reports:
    2012 Progress Report
    2014 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834509C001 The Role of Endocrine Disruptors in Childhood Obesity
    R834509C002 The Role of Endocrine Disruptors in Neurodevelopmental Disorders
    R834509C003 The Mechanisms of Endocrine Disruptors in Laboratory Mice

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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