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Extramural Research

Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

EPA Grant Number: R827039C005
Subproject: this is subproject number 005 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides
Investigators: Gore, Andrea , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects

Description:

Objective:

Our final research project is an experimental neurodevelopmental study that is intended to elucidate the mechanism by which PCBs and other environmental agents adversely affect neuroendocrine and early reproductive development. Using a female rat model, this project will examine the role of developing GnRH neurons and their neuronal and glial inputs in the neuroendocrine dysfunctions that occur in organisms exposed to environmental toxicants.

Supplemental Keywords:

PCBs, exposure, neuroendocrine, reproductive development,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Toxics, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Environmental Chemistry, Health Risk Assessment, Exposure, Epidemiology, pesticides, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Physical Processes, Children's Health, genetic susceptability, Risk Assessment, health effects, pesticide exposure, sensitive populations, health risks, PCBs, biological response, neurodevelopment, children, Human Health Risk Assessment, neurotoxicity, human exposure, pesticide residues, assessment of exposure, growth and development, neurodevelopmental toxicity, exposure pathways, harmful environmental agents, environmental health hazard, dietary exposure, growth & development, developmental disorders, exposure assessment, neurological development

Progress and Final Reports:
2000 Progress Report
2002 Progress Report


Main Center Abstract and Reports:
R827039    Mount Sinai Center for Children's Environmental Health and Disease Prevention Research

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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