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Extramural Research

Clinical Sciences Project

EPA Grant Number: R829391C005
Subproject: this is subproject number 005 , established and managed by the Center Director under grant R829391
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment
Center Director: Lambert, George H.
Title: Clinical Sciences Project
Investigators: Lambert, George H.
Current Investigators: Lambert, George H. , Carmody, Dennis , Johnson, William , Mars, Audrey , Moreno, Rosanne , Seshadri, Kapila
Institution: University of Medicine and Dentistry of New Jersey
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Children's Health , Health Effects

Description:

Objective:

This project addresses three major hypotheses:

  1. The regression of neurological function observed in some children with autistic spectrum disorder, which occurs at the time the child becomes mobile, is a result of exposure to high levels of neurotoxicants.
  2. In children with autistic spectrum disorder, high levels of neurotoxicants can altar regional brain growth patterns as determined by magnetic resonance imaging (MRI).
  3. Susceptibility to developing autism can be influenced by the child or mother’s genotype of enzymes involved in protecting the developing human from chemical-induced oxidative stress.

The specific objectives of the research project are to: (1) compare and contrast the pattern of exposure to environmental chemicals of children with autism and determine if the pattern is different than that observed in children without autism, including documenting carefully mouthing behaviors (frequency and duration of time objects are in the child’s mouth), exploring their environment, and time on the floor; (2) identify if children with autism have altered body burdens of environmental chemicals as compared to children without autism; (3) determine if children with autism who experience regression or loss of neurological function as compared to children without autism that do not experience regression of function have behaviors that potentially expose the children to higher levels of environmental chemicals and/or have higher body burdens of environmental chemicals; (4) determine if children with autism have specific genetic predisposition to chemical-induced toxic effects; (5) determine if children with autism who experience regression of function have specific pattern of brain development as determined by MRI or have specific genetic susceptibility to chemicals induced biologic effects; and (6) determine if the specific recommendation to the parents regarding home environment or altering the child’s exposure to environmental chemicals, such as hand washing and so forth, can reduce significantly the exposure and body burdens of environmental chemicals in these children.

Publications and Presentations:

Publications have been submitted on this subproject: View all 9 publications for this subprojectView all 86 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 8 journal articles for this subprojectView all 49 journal articles for this center

Supplemental Keywords:

children’s health, disease and cumulative effects, ecological risk assessment, environmental chemistry, health risk assessment, risk assessments, susceptibility/sensitive population/genetic susceptibility, toxicology, genetic susceptibility, assessment of exposure, assessment technology, autism, behavioral assessment, behavioral deficits, childhood learning, children, developmental disorders, developmental effects, environmental health hazard, environmental toxicant, exposure assessment, gene-environment interaction, neurodevelopmental, neurological development, neuropathological damage, neurotoxic, neurotoxicity, outreach and education, public health,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Children's Health, genetic susceptability, Biology, Risk Assessment, childhood learning, neurotoxic, gene-environment interaction, developmental effects, children, neurotoxicity, public health, behavioral deficits, assessment of exposure, autism, environmental health hazard, outreach and education, assessment technology, developmental disorders, exposure assessment, neurological development

Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2006 Progress Report


Main Center Abstract and Reports:
R829391    CECEHDPR - University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829391C001 Neurotoxicant Effects on Cell Cycle Regulation of Neurogenesis
R829391C002 Adhesion and Repulsion Molecules in Developmental Neurotoxic Injury
R829391C003 Disruption of Ontogenic Development of Cognitive and Sensory Motor Skills
R829391C004 Exposure Assessment and Intervention Project (EAIP)
R829391C005 Clinical Sciences Project

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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