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Extramural Research

Early Exposure to Lead and Adult Antisocial Outcome

EPA Grant Number: R829389C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Early Exposure to Lead and Adult Antisocial Outcome
Investigators: Lanphear, Bruce , Dietrich, Kim , Hornung, Richard , Ris, Douglas , Wright, John D.
Current Investigators: Ris, Douglas
Institution: Children Hospital of Cincinnati , University of Cincinnati
Current Institution: University of Cincinnati
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Children's Health , Health Effects

Description:

Objective:

The objective of this research project is to examine the effects of early childhood lead exposure in young adults. The specific aims are listed below.

Specific Aim 1: To ascertain the relationship between early lead exposure and antisocial behavior in young adulthood through a followup of a birth cohort of lead-exposed children into adulthood.

Specific Aim 2: To determine via path analysis procedures if academic performance and executive functioning partially mediate the relationship between early lead exposure and adult antisocial behavior.

Publications and Presentations:

Publications have been submitted on this subproject: View all 11 publications for this subprojectView all 132 publications for this center

Supplemental Keywords:

toxicology, ADHD behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Children's Health, Biology, Risk Assessment, lead, pesticides, behavioral assessment, children, neurotoxicity, toxicity, behavioral deficits, biological markers, exposure assessment, biomarker

Progress and Final Reports:
2003 Progress Report
2004 Progress Report
2005 Progress Report
Final Report


Main Center Abstract and Reports:
R829389    CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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