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Extramural Research

Neurobehavioral Effects of Prevalent Toxicants in Children

EPA Grant Number: R829389C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Neurobehavioral Effects of Prevalent Toxicants in Children
Investigators: Lanphear, Bruce , Bearer, Cynthia , Dietrich, Kim , Hornung, Richard , Khoury, Jane , Ris, Douglas , Yolton, Kimberly
Current Investigators: Lanphear, Bruce , Dietrich, Kim
Institution: Children Hospital of Cincinnati , University of Cincinnati
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Children's Health , Health Effects

Description:

Objective:

The objective of this research project is to test the efficacy of an intervention for the primary prevention of lead toxicity, as measured by lead concentration and neurobehavioral functioning at 36 months of age.  The control arm for the lead hazard reduction intervention has grown in scope to allow the evaluation of broader and more costly lead hazard controls and the addition of another physical housing-based intervention designed to reduce unintentional injury.  We hypothesize that the installation of multiple passive measures in the households of index children, randomized to the intervention group, will reduce unintentional injury across residential mechanisms by 30 percent in the injury arm compared to the lead arm.  We also have added a 4-week home visit to the protocol to collect breast milk from breastfeeding mothers and conduct a newborn behavioral evaluation.

Publications and Presentations:

Publications have been submitted on this subproject: View all 19 publications for this subprojectView all 132 publications for this center

Supplemental Keywords:

toxicology, ADHD, behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants, lead-based paint, lead hazard control,, RFA, Health, Scientific Discipline, Toxics, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, pesticides, Risk Assessments, Children's Health, Biology, Risk Assessment, pesticide exposure, lead, behavioral assessment, children, neurotoxicity, toxicity, behavioral deficits, biological markers, exposure assessment

Progress and Final Reports:
2003 Progress Report
2004 Progress Report
2005 Progress Report
Final Report


Main Center Abstract and Reports:
R829389    CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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