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Extramural Research

2006 Progress Report: Community-Based Participatory Research Project

EPA Grant Number: R831709C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R831709
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: University of Washington Center for Child Environmental Health Risks Research
Center Director: Faustman, Elaine
Title: Community-Based Participatory Research Project
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2005 through October 31,2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Children's Health , Health Effects

Description:

Objective:

The objectives of the research project are to:  (1) intervene to reduce children’s exposure to pesticides, including the development of a culturally appropriate intervention to break the take-home pathway; and (2) foster partnerships between academic researchers and the community in which information requested by the community and basic research deficiencies/gaps are translated into studies that address the health needs of both.
 
As a result of receipt of donor funds, we were able to increase the scope of work for this research project to include collection of additional biological specimens that will enhance the project further.  The additional tasks include:  (1) comparing the levels of organophosphorus pesticide (OP) parent compounds in the blood of adult farmworkers and non-farmworkers, adjusting for the multiple pathways; (2) compare levels of pesticide residues in saliva to those in urine and blood to determine reliability and validity of data and to assess more accurately the presence of OPs; (3) conduct blood analysis through finger sticks to ascertain cholinesterase levels; and (4) conduct analysis of buccal cell samples in adults and children of farmworkers and nonfarmworkers to gain a better understanding of the mechanisms of toxicity of OPs.

Progress Summary:

Data collection for farmworkers and non-farmworkers was completed.  Local interviewers were hired and trained in study procedures.  Study participants have been recruited and we have completed the data collection for the harvest season phase and the non-spray season phase of the research study.  In each case, this included an initial and follow-up survey and collection of urine, venous blood, finger stick blood, buccal cells, saliva, and house and vehicle dust samples from farmworker and non-farmworker families as indicated by the study protocol.  Specimen samples collected were shipped to CDC and the University of Washington for analyses.  Analyses are currently under way.  All surveys have been data entered and a dataset for analyses is currently being compiled.  In autumn of 2006, we will survey and collect urine and dust samples from warehouse workers.  In preparation for that phase of the study, we have developed warehouse worker questionnaires, have piloted the questionnaires, and have submitted them to our IRB.  We have also designed the study protocol for the warehouse worker data collection.
 
SIGNIFICANCE: Perhaps the most significant achievements are two:  first, we provided empirical support for the take-home pathway of pesticides to the children of farmworkers; second, we demonstrated that the urinary metabolites of pesticides among children were directly associated with urinary metabolites of the farmworker in the household.  Once the data for this study are analyzed, we will be able to identify the parent compound of OP pesticides in blood.  We also will be able to examine cholinesterase levels in farmworkers (as opposed to pesticide handlers) and in their children.  Another innovative achievement is the ability and practice of providing accurate scientific data to farmworkers and growers in the Valley.  This led to numerous opportunities to address media throughout the state and country.  This study is one of the largest studies done with farmworkers and pesticide exposure that provides data from biomarkers as well as survey information.

Future Activities:

For the next funding period, we will complete the data collection of the warehouse workers. We will work with the Centers for Disease Control and the University of Washington to analyze the biological samples.
We will plan for and begin the reporting back to participants of test results and begin home meetings to educate participants on ways they can protect themselves and their families from pesticide exposure.
We will work with the local Spanish-speaking radio station to disseminate messages on pesticide safety and protection.


Journal Articles on this Report : 3 Displayed | Download in RIS Format

Other subproject views: All 14 publications 10 publications in selected types All 10 journal articles
Other center views: All 175 publications 127 publications in selected types All 107 journal articles

Type Citation Sub Project Document Sources
Journal Article Coronado GD, Vigoren EM, Thompson B, Griffith WC, Faustman EM. Organophosphate pesticide exposure and work in pome fruit: evidence for the take-home pesticide pathway. Environmental Health Perspectives 2006;114(7):999-1006.
abstract available   full text available
R831709 (2005)
R831709 (2007)
R831709C003 (2006)
R832733 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471.
    abstract available   full text available
    R831709 (2005)
    R831709 (2007)
    R831709C003 (2005)
    R831709C003 (2006)
    R826710 (Final)
    R829391 (2004)
    R829391 (2005)
    R829391 (2006)
    R829391C005 (2006)
    R831710 (2004)
    R831710 (2005)
    R831710 (Final)
    R831710C001 (2006)
    R831710C002 (2006)
    R831710C004 (2006)
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
    R832139 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Strong LL, Thompson B, Koepsell TD, Meischke H. Factors associated with pesticide safety practices in farmworkers. American Journal of Industrial Medicine 2008;51(1):69-81.
    abstract available   full text available
    R831709 (2005)
    R831709 (2006)
    R831709 (2007)
    R831709C003 (2006)
    R831709C003 (2007)
    R832740 (Final)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
    Exit
  • Supplemental Keywords:

    children’s health, epidemiology, genetics, health risk assessment, risk assessment, assessment of exposure, asthma, children’s environmental health, diesel exhaust, environmental risks, exposure assessment, genetic mechanisms, genetic risk factors, genetic susceptibility, maternal exposure, nutritional risk factors, Environmental Management, Scientific Discipline, Health, RFA, Risk Assessment, Health Risk Assessment, Children's Health, Biochemistry, Environmental Chemistry, health effects, children's environmental health, assessment of exposure, developmental neurotoxicity, agricultural community, community-based intervention, pesticide exposure, genetic polymorphisms, biological response, environmental health, environmental risks, children's vulnerability
    , RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Environmental Chemistry, Health Risk Assessment, Biochemistry, Children's Health, Risk Assessment, health effects, pesticide exposure, environmental health, community-based intervention, developmental neurotoxicity, environmental risks, biological response, Human Health Risk Assessment, children's vulnerablity, assessment of exposure

    Progress and Final Reports:
    Original Abstract
    2004 Progress Report
    2005 Progress Report
    2007 Progress Report


    Main Center Abstract and Reports:
    R831709    University of Washington Center for Child Environmental Health Risks Research

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R831709C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
    R831709C002 Genetic Susceptibility to Pesticides
    R831709C003 Community-Based Participatory Research Project
    R831709C004 Pesticide Exposure Pathways Research Project

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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