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Extramural Research

Manganese, Iron, Cadmium, and Lead Transport from the Environment to Critical Organs During Gestation and Early Development in a Rat Model

EPA Grant Number: R831725C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R831725
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Harvard Center for Children’s Environmental Health and Disease Prevention Research
Center Director: Hu, Howard
Title: Manganese, Iron, Cadmium, and Lead Transport from the Environment to Critical Organs During Gestation and Early Development in a Rat Model
Investigators: Brain, Joseph D. , Molina, Ramon , Wessling-Resnick, Marianne
Institution: Harvard School of Public Health
EPA Project Officer: Callan, Richard
Project Period: June 1, 2004 through May 31, 2009 (Extended to May 31, 2011)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Children's Health , Health Effects

Description:

Objective:

The objective of this research project is to explore the transport of iron, manganese, cadmium, and lead from environments experienced by children to the blood and critical organs like the brain, heart, liver, and kidneys.  We seek to better understand metal exposures of children and their mothers in settings like Tar Creek by:  (1) utilizing exposures during and after pregnancy, (2) using metal ions as well as complex environmental samples from Tar Creek, and (3) comparing different routes of entry from the environment into the body.  We also will explore the role of toxic metals and iron status as they interact to influence metal absorption.

Publications and Presentations:

Publications have been submitted on this subproject: View all 12 publications for this subprojectView all 35 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 12 journal articles for this subprojectView all 25 journal articles for this center

Supplemental Keywords:

children, Native American, tribal, mixtures, lead, PBPK, community, Superfund, intervention, environmental management,, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, Waste, Environmental Chemistry, Health Risk Assessment, Hazardous Waste, Biochemistry, Children's Health, Hazardous, Risk Assessment, community-based intervention, fate and transport , lead, animal model, developmental toxicity, Human Health Risk Assessment, manganese, iron, neurodevelopmental toxicity, children's environmental health, cadmium, metal wastes, mining waste, human health risk, metals, mining wastes

Progress and Final Reports:
2004 Progress Report
2005 Progress Report
2007 Progress Report
2008 Progress Report


Main Center Abstract and Reports:
R831725    Harvard Center for Children’s Environmental Health and Disease Prevention Research

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831725C001 Metals, Nutrition, and Stress in Child Development
R831725C002 Exposure Assessment of Children and Metals in Mining Waste: Composition, Environmental Transport, and Exposure Patterns
R831725C003 Manganese, Iron, Cadmium, and Lead Transport from the Environment to Critical Organs During Gestation and Early Development in a Rat Model
R831725C004 Metals Neurotoxicity Research Project

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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