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Extramural Research

Inner City Toxicants, Child Growth and Development

EPA Grant Number: R831711
Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research.
Center Director: Wolff, Mary S.
Title: Inner City Toxicants, Child Growth and Development
Investigators: Wolff, Mary S.
Current Investigators: Wolff, Mary S. , Brenner, Barbara , Chen, Jia , Claudio, Luz , Engel, Stephanie M. , Galvez, Maida , Godbold, James , Teitelbaum, Susan , Wetmur, James G.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 30, 2008 (Extended to October 30, 2010)
Project Amount: $4,004,980
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Children's Health , Health Effects , Human Health

Description:

Objective:

Children in America’s cities are at risk of exposure to multiple known and potential developmental toxicants, and particular concern has been raised about newly identified, widely prevalent chemicals – the so-called endocrine disruptors (EDs), which include phthalates and alkyl phenols. They have become widely dispersed in the urban built-environment, and significant levels of phthalates are now nearly ubiquitous in the bodies of Americans. Highest exposures occur in children and in minorities. Yet little is known, either of children’s pathways of exposure to EDs, or their presence and their levels in children, or of the human developmental toxicity of EDs. To address these gaps, the Mount Sinai Center is undertaking research (1) to characterize the levels and sources of children’s exposures to contemporary-use EDs in the urban built environment; (2) to study relationships between EDs and neurobehavioral development; (3) to study relationships among ED exposures, diet, physical activity, and somatic growth; and (4) to characterize enzymatic polymorphisms that may modulate individual susceptibility to EDs.

Approach:

During years 1-5 of the Center, we studied effects of exposure to environmental chemicals on children’s growth and neurobehavioral development. We characterized children’s exposures to pesticides, polychlorinated biphenyls (PCBs), DDT, chlordane and lead in three birth cohorts from East and Northern Harlem, New York City. We also evaluated susceptibility factors related to certain exposures. With the East Harlem community, we developed, deployed and field-tested integrated pest management methods to reduce children’ exposures to neurotoxic pesticides. In a population of African-American men whose mothers had participated in the Collaborative Perinatal Project during the 1960s, we measured in utero exposure to PCBs and found associated decrements in intelligence that were still evident at age 17 years. We are now studying timing of pubertal development. PCBs, but not DDE, were strongly associated with income, a socioeconomic status indicator, in this cohort. In two recently established (1998-2001) East Harlem birth cohorts, we found evidence for common (but not universal) exposure to organophosphate and pyrethroid pesticides. Exposures to PCBs and related chlorinated hydrocarbons were quite low, but PCB levels were still associated with fish intake. In utero exposure to organophosphates was associated with decreased head circumference of infants at birth, but only in mothers with low PON1 activity. In years 6-10, we continue to follow the birth cohorts established in the first grant cycle, to evaluate effects on later childhood development of these prenatal exposures as well as the prevalent ED exposures.

Expected Results:

Project 1 is a Community-Based Participatory Research (CBPR) project that is studying childhood obesity in relation to structural features and endocrine disruptor (ED) exposures in the urban built environment of East Harlem. We are assessing accessibility to physical activity resources and to healthy foods. Quantitative physical activity is being assessed using a newly developed protocol that records daily pedometer readings and activity diaries. Children’s usage patterns of EDs are being determined through a “product-use” questionnaire (developed in our CBPR). We have completed a 6-month study to evaluate biomarker protocols in 34 6-8 year-old children of phthalates, phenols, and phytoestrogens and the sources of those chemicals, with data analysis underway. Reported product usage is being compared with children’s body burdens of new-age EDs as determined in urine. Findings will guide sample collection and analysis for both Projects 1 and 2, as well as lead to an improved product-use questionnaire. A 3-year longitudinal study has begun in 150 6-8 yr-old children to evaluate risk for obesity in relation to built environment factors and ED exposures.

We will continue to examine temporal variability and reliability of the EDs in order to determine optimal urine sampling strategies, to examine ED exposure levels and their relationship to diet, physical activity level and weight, and to compare availability, proximity and density of resources (GIS data) with individual level factors (Neighborhood questionnaire) such as access, knowledge, utilization, dietary quality and physical activity level.

Project 2 is a continuing prospective epidemiologic study of an ethnically diverse birth cohort of infants born at Mount Sinai. We are now conducting neurobehavioral and anthropometric assessments, including %-body fat, at the child’s 4th, 6th, and 7th year. The aim is to assess whether in utero and/or childhood exposure to pesticides and endocrine disruptors, specifically organophosphates, pyrethroids, PCBs, phthalates, and bisphenol A, are associated with childhood growth and neurodevelopment in children in New York City. The possible modulating influences of polymorphisms and enzymatic activity involving paraoxonases, lipases, and glucuronidases will also be evaluated, in collaboration with Project 3.

We are finalizing the statistical analyses of birth outcomes in relationship with maternal prenatal exposure to alkylphosphate pesticide metabolites, PCBs and DDT, lead, and paraoxonase activity as well as genotypes. We have started our analysis of prenatal exposure to pesticide metabolites, PCBs and DDT, lead, and PON expression and the Brazelton Neonatal Behavioral Assessment, which was given within 48 hours of delivery, and the Bayley Scales of Infant Development which were given at years 1 and 2.

Project 3 has been studying seven genetic polymorphisms in the enzymes that activate and detoxify organophosphates and other pesticides in the population of mothers and infants enrolled in Project 2. Genotype-phenotype associations of PON1 vary by allele, are independent of race/ethnicity, and are stronger for infants than mothers. Results suggest that infants may be more susceptible to toxic effects of PON1 substrates. We have developed a new robust single molecule-based haplotyping technology that was verified by showing haplotype-based variation in PON1 activity in mothers heterozygous at two loci, a result that could not have been determined by genotyping or by haplotype inference. High throughput assays for UGT2B7 and lingual lipase are under development, to address our aims to investigate these new ED-related susceptibility factors.

We will complete the examination inferred versus molecular paraoxonase-1 haplotypes in our population. We have found that twenty of the 137 individuals showed different molecular haplotypes than the inferred haplotypes, a 15% disconcordancy, suggesting caution in the use of statistical inference for haplotypes. When the most probable predicted diplotype had a probability of 50-65%, 14 of 31 were discordant (45%). The UGT2B7 promoters of our African-American population will be resequenced. The UGT2B7 results will be compared to exposure measurements and with outcome measurements from Project 2.

In addition, the lipase/amylase data will be used to select individuals with varying lipase/amylase ratios for analysis of phthalate metabolism in collaboration with Dr. Dana Barr at the CDC by HPLC-MS. Goals include establishing an inexpensive biomarker assay to permit large population studies of human variation in phthalate metabolism, and to compare these biomarker results with exposure measurements and outcome measurements from Project 2.


Journal Articles: 118 Displayed | Download in RIS Format

Other center views: All 254 publications 140 publications in selected types All 118 journal articles

Type Citation Sub Project Document Sources
Journal Article Anderson HA, Wolff MS. Special fish contaminants issue. Environmental Research 2005;97(2):125-126 (introductory commentary).
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  • Journal Article Belogolovkin V, Engel SM, Ferrara L, Eddleman KA, Stone JL. Does sonographic determination of placental location predict fetal birth weight in diamniotic-dichorionic twins? Journal of Ultrasound in Medicine 2007;26(2):187-191.
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  • Journal Article Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84.
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  • Journal Article Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, Holzman IR, Wolff MS. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environmental Health Perspectives 2004;112(3):388-391.
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  • Journal Article Bienenfeld LA, Golden AL, Garland EJ. Consumption of fish from polluted waters by WIC participants in east Harlem. Journal of Urban Health 2003;80(2):349-358.
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  • Journal Article Biro FM, Galvez MP, Greenspan LC, Succop PA, Vangeepuram N, Pinney SM, Teitelbaum S, Windham GC, Kushi LH, Wolff MS. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics 2010;126(3):e583-e590.
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  • Journal Article Borrell LN, Factor-Litvak P, Wolff MS, Susser E, Matte TD. Effect of socioeconomic status on exposures to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) among pregnant African-American women. Archives of Environmental Health 2004;59(5):250-255.
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  • Journal Article Braganza SF, Galvez MP, Mencin AA, Ozuah PO. Weighting the appropriate uses of supplemental zinc. Contemporary Pediatrics 2006;23(7):66-74.
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  • Journal Article Braganza SF, Galvez MP, Ozuah PO. Part two: When parents ask about diet therapy for ADHD. Contemporary Pediatrics 2006;23(5):47-49 R831711 (2007)
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    Journal Article Braganza SF, Galvez MP, Ozuah PO. When parents ask about diet therapy for ADHD. Contemporary Pediatrics 2006;23(5):47-49. R831711 (2005)
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  • Journal Article Brand SR, Engel SM, Canfield RL, Yehuda R. The effect of maternal PTSD following in utero trauma exposure on behavior and temperament in the 9-month-old infant. Annals of the New York Academy of Sciences 2006;1071:454-458.
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  • Journal Article Brenner BL, Markowitz S, Rivera M, Romero H, Weeks M, Sanchez E, Deych E, Garg A, Godbold J, Wolff MS, Landrigan PJ, Berkowitz G. Integrated pest management in an urban community: a successful partnership for prevention. Environmental Health Perspectives 2003;111(13):1649-1653.
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  • Journal Article Britton JA, Teitelbaum SL, Wolff MS. Correspondence re:Schoen et al., Lack of association between adipose tissue distribution, and insulin-like growth factor-I and insulin-like growth factor binding protein-3 in men and women. Cancer Epidemiol. Biomark. Prev., 11:581-586, 2002. Cancer Epidemiology, Biomarkers & Prevention 2003;12(6):586.
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  • Journal Article Britton JA, Wolff MS, Lapinski R, Forman J, Hochman S, Kabat GC, Godbold J, Larson S, Berkowitz GS. Characteristics of pubertal development in a multi-ethnic population of nine-year-old girls. Annals of Epidemiology 2004;14(3):179-187.
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  • Journal Article Chemtob CM, Conroy DL, Hochauser CJ, Laraque D, Banks J, Schmeidler J, Dela Cruz M, Nelsen WC, Landrigan PJ. Children who lost a parent as a result of the terrorist attacks of September 11, 2001: registry construction and population description. Death Studies 2007;31(1):87-100.
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  • Journal Article Chen A, Zhang J, Zhou L, Gao E, Chen L, Rogan WJ, Wolff MS. DDT serum concentration and menstruation among young Chinese women. Environmental Research 2005;99(3):397-402.
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  • Journal Article Chen J, Kumar M, Chan W, Berkowitz G, Wetmur JG. Increased influence of genetic variation on PON1 activity in neonates. Environmental Health Perspectives 2003;111(11):1403-1409.
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  • Journal Article Chen J, Chan W, Wallenstein S, Berkowitz G, Wetmur JG. Haplotype-phenotype relationships of paraoxonase-1. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):731-734.
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  • Journal Article Claudio L. Breast cancer takes center stage. Environmental Health Perspectives 2004;112(2):A92-A95 (NIEHS News).
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  • Journal Article Claudio L. Making progress on breast cancer. Environmental Health Perspectives 2006;114(2):A98-A99 (NIEHS News).
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  • Journal Article Claudio L, Stingone JA, Godbold J. Prevalence of childhood asthma in urban communities: the impact of ethnicity and income. Annals of Epidemiology 2006;16(5):332-340.
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  • Journal Article Claudio L, Stingone J. Improving sampling and response rates in children's health research through participatory methods. Journal of School Health 2008;78(8):445-451.
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  • Journal Article Cohn BA, Cirillo PM, Wolff MS, Schwingi PJ, Cohen RD, Sholtz RI, Ferrara A, Christianson RE, van den Berg BJ, Siiteri PK. DDT and DDE exposure in mothers and time to pregnancy in daughters. Lancet 2003;361(9376):2205-2206.
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  • Journal Article Cohn BC, Cirillo PM, Wolff MS, Schwingl PJ, et al. In utero DDT and DDE exposure may alter time to pregnancy in daughters 30 years later. Lancet 2003;361(9376):2205-2006. R831711 (2005)
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    Journal Article Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446.
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  • Journal Article Diplas AI, Hu J, Lee M-J, Ma YY, Lee YL, Lambertini L, Chen J, Wetmur JG. Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. Nucleic Acids Research 2009;37(21):7039-7046.
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  • Journal Article Dunson DB, Herring AH, Engel SM. Bayesian selection and clustering of polymorphisms in functionally related genes. Journal of the American Statistical Association 2008;103(482):534-546.
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  • Journal Article Edwards ES, Green N, Henry CJ, Landrigan PJ, Swartz D. Tracking children's health to age 21. Science 2003;302(5646):781 (letter comment on Science 2003;301(5630):162-163).
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  • Journal Article Engel SM, Berkowitz GS, Yehuda R, Wolff MS. Psychological trauma associated with the World Trade Center attacks and its effect on pregnancy outcome. Paediatric and Perinatal Epidemiology 2005;19(5):334-341.
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  • Journal Article Engel SM, Levy B, Liu Z, Kaplan D, Wolff MS. Xenobiotic phenols in early pregnancy amniotic fluid. Reproductive Toxicology 2006;21(1):110-112.
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  • Journal Article Engel SM, Olshan AF, Siega-Riz AM, Savitz DA, Chanock SJ. Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth. American Journal of Obstetrics and Gynecology 2006;195(5):1231.e1-1231.e11.
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  • Journal Article Engel SM, Hertz-Picciotto I, Schramm M, Watt-Morse M. Recreational Physical Activity Practices Before and During Pregnancy. Obstetrics and Gynecology 2006. R831711 (2005)
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    Journal Article Engel SM, Berkowitz GS, Barr DB, Teitelbaum SL, Siskind J, Meisel SJ, Wetmur JG, Wolff MS. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. American Journal of Epidemiology 2007;165(12):1397-1404.
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  • Journal Article Engel SM, Janevic TM, Stein CR, Savitz DA. Maternal smoking, preeclampsia, and infant health outcomes in New York City, 1995-2003. American Journal of Epidemiology 2009;169(1):33-40.
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  • Journal Article Engel SM, Zhu C, Berkowitz GS, Calafat AM, Silva MJ, Miodovnik A, Wolff MS. Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort. NeuroToxicology 2009;30(4):522-528.
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  • Journal Article Engel SM, Miodovnik A, Canfield RL, Zhu C, Silva MJ, Calafat AM, Wolff MS. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environmental Health Perspectives 2010;118(4):565-571.
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  • Journal Article Eskenazi B, Landrigan PJ. Environmental Health Perspectives and children's environmental health. Environmental Health Perspectives 2002;110(10):A559-A560. R831711 (2007)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429.
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  • Journal Article Etzel RA, Crain EF, Gitterman BA, Oberg C, Scheidt P, Landrigan PJ. Pediatric environmental health competencies for specialists. Ambulatory Pediatrics 2003;3(1):60-63.
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  • Journal Article Etzel RA, Balk SJ, Reigart JR, Landrigan PJ. Environmental health for practicing pediatricians. Indian Pediatrics 2003;40(9):853-860.
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  • Journal Article Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462.
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    R831709 (2007)
    R831710 (2004)
    R831710 (2005)
    R831710 (Final)
    R832141 (2006)
    R832141 (2007)
    R832141 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Fewtrell LJ, Pruss-Ustun A, Landrigan P, Ayuso-Mateos JL. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure. Environmental Research 2004;94(2):120-133.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Full-text: Science Direct-Full Text HTML
    Exit
  • Abstract: Science Direct-Abstract
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  • Other: Science Direct-Full Text PDF
    Exit
  • Journal Article Galvez MP, Frieden TR, Landrigan PJ. Obesity in the 21st century. Environmental Health Perspectives 2003;111(13):A684-A685 (editorial).
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Journal Article Galvez MP, Peters R, Graber N, Forman J. Effective risk communication in children's environmental health:lessons learned from 9/11. Pediatric Clinics of North America 2007;54(1):33-46.
    abstract available   full text available
    R831711 (2005)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Abstract: Elsevier-Abstract
    Exit
  • Journal Article Galvez MP, Morland K, Raines C, Kobil J, Siskind J, Godbold J, Brenner B. Race and food store availability in an inner-city neighborhood. Public Health Nutrition 2008;11(6):624-631.
    abstract available   full text available
    R831711 (2005)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2007)
  • Abstract from PubMed
  • Full-text: Cambridge Journals-Full Text HTML
    Exit
  • Abstract: Cambridge Journals-Abstract
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  • Other: Cambridge Journals-Full Text PDF
    Exit
  • Journal Article Galvez, MP, Graber NM, Sheffield PE, Forman JA , Balk SJ. Hot topics in environmental health. Child product safety: delivering guidance amid anxiety. Contemporary Pediatrics 2009;26(7):34-47.
    abstract available   full text available
    R831711 (Final)
  • Abstract: Modern Medicine-Abstract
    Exit
  • Journal Article Galvez MP, Hong L,Choi E, Liao L, Godbold J, Brenner B. Childhood obesity and neighborhood food-store availability in an inner-city community. Academic Pediatrics 2009;9(5):339-343.
    abstract available   full text available
    R831711 (Final)
  • Full-text from PubMed
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  • Associated PubMed link
  • Abstract: Academic Pediatrics-Abstract
    Exit
  • Journal Article Galvez MP, Pearl M, Yen IH. Childhood obesity and the built environment. Current Opinion in Pediatrics 2010;22(2):202-207.
    abstract available   full text available
    R831711 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Current Opinion in Pediatrics-Abstract
    Exit
  • Journal Article Galvez M, Vanable L, Forman JA, Landrigan PJ, Akeredolu E, Leighton J, Nagin D. Childhood lead poisoning from commercially manufactured French ceramic dinnerware-New York City, 2003. Morbidity and Mortality Weekly Reports 2004;53(26):584-586.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Full-text: CDC-Full Text HTML
  • Abstract: CDC-Abstract
  • Other: CDC-Full Text PDF
  • Journal Article Garg A, Landrigan PJ. Children's environmental health: new gains in science and policy. Ann Am Acad Polit Soc Sci 2002;584(1):135-144.
    abstract available  
    R831711 (2007)
  • Abstract: Sage Publications-Abstract
    Exit
  • Journal Article Godbold JH. Re:"Statistical analysis of correlated data using generalized estimating equations: an orientation." American Journal of Epidemiology 2003;158(3):289.
    abstract available   full text available
    R831711 (Final)
  • Full-text: Oxford Journals-Full Text
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  • Abstract: Oxford Journals-Abstract
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  • Other: Oxford Journals-Full Text PDF
    Exit
  • Journal Article Goldman L, Falk H, Landrigan PJ, Balk SJ, Reigart JR, Etzel RA. Environmental pediatrics and its impact on government health policy. Pediatrics 2004;113(Suppl 3):1146-1157.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Full-text: Pediatrics-Full Text HTML
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  • Abstract: Pediatrics
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  • Other: Pediatrics-Full Text
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  • Journal Article Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals. Lancet 2006;368(9553):2167-2178.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Abstract: Lancet - Abstract
    Exit
  • Journal Article Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471.
    abstract available   full text available
    R831711 (2005)
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    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
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    R826710 (Final)
    R829391 (2004)
    R829391 (2005)
    R829391 (2006)
    R829391C005 (2006)
    R831709 (2005)
    R831709 (2007)
    R831709C003 (2005)
    R831709C003 (2006)
    R831710 (2004)
    R831710 (2005)
    R831710 (Final)
    R831710C001 (2006)
    R831710C002 (2006)
    R831710C004 (2006)
    R832139 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Kadlubar FF, Berkowitz GS, Delongchamp RR, Wang C, Green BL, Tang G, Lamba J, Schuetz E, Wolff MS. The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiology Biomarkers and Prevention 2003;12(4):327-331.
    abstract available   full text available
    R831711 (2005)
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    R825816 (Final)
  • Abstract from PubMed
  • Full-text: Cancer Epidemiology, Biomarkers and Prevention-Full Text HTML
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  • Journal Article Lamb MR, Taylor S, Liu X, Wolff MS, Borrell L, Matte TD, Susser ES, Factor-Litvak P. Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environmental Health Perspectives 2006;114(5):779-785.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Lambertini L, Diplas AI, Lee MJ, Sperling R, Chen J, Wetmur J. A sensitive functional assay reveals frequent loss of genomic imprinting in human placenta. Epigenetics 2008;3(5):261-269.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
    R831711C003 (2007)
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  • Associated PubMed link
  • Full-text: Landes Bioscience-Full Text PDF
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  • Abstract: Landes Bioscience-Abstract
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  • Journal Article Lambertini L, Diplas AI, Wetmur J, Lee MJ, Chen J. Evaluation of genomic imprinting employing the analysis of Loss of Imprinting (LOI) at the RNA level:preliminary results. European Journal of Oncology 2009;14(3):161-169. R831711 (Final)
    not available
    Journal Article Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children's health and the environment: public health issues and challenges for risk assessment. Environmental Health Perspectives 2004;112(2):257-265.
    abstract available   full text available
    R831711 (2005)
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    R831711C001 (2006)
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    R831710 (2004)
    R831710 (2005)
    R831710 (Final)
    R831710C001 (2004)
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  • Journal Article Landrigan PJ, Slutsky J. Are learning disabilities linked to environmental toxins? Learning Disabilities: A Contemporary Journal 2004;15:7-12.
    abstract available   full text available
    R831711 (2005)
    R831711 (Final)
  • Full-text: Learning Disabilities Worldwide- Full Text HTML
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  • Other: Learning Disabilities Worldwide - Full Text PDF
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  • Journal Article Landrigan PJ, Lioy PJ, Thurston G, Berkowitz G, Chen LC, Chillrud SN, Gavett SH, Georgopoulos PG, Geyh AS, Levin S, Perera F, Rappaport SM, Small C, NIEHS World Trade Center Working Group. Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 2004;112(6):731-739.
    abstract available   full text available
    R831711 (2007)
    R831711C002 (2004)
    R827351 (2003)
    R827351 (Final)
    R830827 (2004)
    R830827 (Final)
    R832141 (2005)
    R832141 (2007)
  • Full-text from PubMed
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  • Journal Article Landrigan PJ. Children as a vulnerable population. International Journal of Occupational Medicine and Environmental Health 2004;17(1):175-177.
    abstract available   full text available
    R831711 (2005)
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    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Full-text: Instytut Medycyny Pracy Im.-Full Text PDF
    Exit
  • Journal Article Landrigan PJ.Environmental threats to children’s health – the promise of the National Children’s Study. NECOEM Reporter 2005;2(13):1-2. R831711 (2005)
    R831711 (2007)
  • Full-text: New England College of Occupational and
    Environmental Medicine (NECOEM) - Full Text PDF

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  • Journal Article Landrigan PJ. Environmental exposures and children’s health challenges. Zero to Three 2005;26(2):8-10.
    abstract available  
    R831711 (2005)
    R831711 (2007)
    R831711 (Final)
  • Abstract: Education Resources Information Center (ERIC)-Abstract
  • Other: ZerotoThree-TOC
    Exit
  • Journal Article Landrigan PJ, Tamburlini G. Children's health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113(10):A646-A647.
    abstract available   full text available
    R831711 (2005)
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    R831711 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Landrigan PJ, Sonawane B, Butler RN, Trasande L, Callan R, Droller D. Early environmental origins of neurodegenerative disease in later life. Environmental Health Perspectives 2005;113(9):1230-1233.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Landrigan PJ, Newman B. Children and other high-risk workers as a special challenge to occupational health services. SJWEH Supplements 2005;1:43-45.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text: SJWEH-Full Text PDF
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  • Abstract: SJWEH-Abstract
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  • Journal Article Landrigan PJ, Tamburlini G. Children’s health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113(10):A646-A647 (editorial).
    full text available
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text: Environmental Health Perspectives Full Text
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  • Other: Environmental Health Perspectives PDF
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  • Journal Article Landrigan PJ, Trasande L. More kids chronically ill. Poughkeepsie Journal 2005. R831711 (2005)
    not available
    Journal Article Landrigan PJ. Environmental pediatrics and the ecological imperative. EcoHealth 2006;3(2):75-76 (editorial).
    abstract available   full text available
    R831711 (2005)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C003 (2006)
  • Full-text: EcoHealth-Full Text PDF
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  • Abstract: SpringerLink-Content Excerpt
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  • Journal Article Landrigan PJ, Trasande L, Thorpe LE, Gwynn C, Lioy PJ, D'Alton ME, Lipkind HS, Swanson J, Wadhwa PD, Clark EB, Rauh VA, Perera FP, Susser E. The National Children's Study: a 21-year prospective study of 100,000 American children. Pediatrics 2006;118(5):2173-2186.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
    R832141 (2007)
    R832141 (Final)
  • Abstract from PubMed
  • Abstract: Pediatrics - Abstract
    Exit
  • Journal Article Landrigan PJ, Woolf AD, Gitterman B, Lanphear B, Forman J, Karr C, Moshier EL, Godbold J, Crain E. The Ambulatory Pediatric Association fellowship in pediatric environmental health: a 5-year assessment. Environmental Health Perspectives 2007;115(10):1383-1387.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Landrigan PJ, Trasande L, Swanson JM. Genetics, altruism, and the National Children’s Study. American Journal of Medical Genetics Part A 2008;146(3):294-296.
    abstract available   full text available
    R831711 (2007)
  • Abstract from PubMed
  • Full-text: Wiley Online-Full Text PDF
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  • Other: Wiley Online-Full Text HTML
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  • Journal Article Landrigan PJ, Forman J, Galvez M, Newman B, Engel SM, Chemtob C. Impact of September 11 World Trade Center disaster on children and pregnant women. Mount Sinai Journal of Medicine 2008;75(2):129-134.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
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  • Journal Article Landrigan PJ, Rauh VA, Galvez MP. Environmental justice and the health of children. Mount Sinai Journal of Medicine 2010;77(2):178-187.
    abstract available   full text available
    R831711 (Final)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
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  • Journal Article Landrigan P, Garg A, Droller DBJ. Assessing the effects of endocrine disruptors in the National Children's Study. Environmental Health Perspectives 2003;111(13):1678-1682.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Lee YL, Teitelbaum S, Wolff MS, Wetmur JG, Chen J. Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York City. Journal of Genetics 2010;89(4):417-423.
    abstract available   full text available
    R831711 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Indian Academy of Sciences-Full Text PDF
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  • Abstract: Springer-Abstract
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  • Journal Article Liu Z, Wolff MS, Moline J. Analysis of environmental biomarkers in urine using an electrochemical detector. Journal of Chromatography B 2005;819(1):155-159.
    abstract available   full text available
    R831711 (2005)
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-Full Text PDF
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  • Journal Article Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglas-Kuperus N, Hertz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma ER, Altshul LM, Heinzow B, Pagano JJ, Jensen AA. Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environmental Health Perspectives 2003;111(1):65-70.
    abstract available   full text available
    R831711 (2004)
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Journal Article Magdo HS, Forman J, Graber N, Newman B, Klein K, Satlin L, Amler RW, Winston JA, Landrigan PJ. Grand rounds: nephrotoxicity in a young child exposed to uranium from contaminated well water. Environmental Health Perspectives 2007;115(8):1237-1241.
    abstract available   full text available
    R831711 (2007)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP
  • Journal Article Miodovnik A, Engel SM, Zhu C, Ye X, Soorya LV, Silva MJ, Calafat AM, Wolff MS. Endocrine disruptors and childhood social impairment. NeuroToxicology 2011;32(2):261-267.
    abstract available   full text available
    R831711 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Science Direct-Full Text HTML
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  • Abstract: Science Direct-Abstract
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  • Other: Science Direct-Full Text PDF
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  • Journal Article Needleman HL, Landrigan PJ. What level of lead in blood is toxic for a child? American Journal of Public Health 2004;94(1):8.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: American Journal of Public Health-Full Text HTML
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  • Abstract: American Journal of Public Health-Abstract
    Exit
  • Other: American Journal of Public Health-Full Text PDF
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  • Journal Article Northridge J, Ramirez OF, Stingone JA, Claudio L. The role of housing type and housing quality in urban children with asthma. Journal of Urban Health 2010;87(2):211-224.
    abstract available   full text available
    R831711 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: SpringerLink-Abstract
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  • Journal Article Pirisi A. Philip Landrigan: children's health crusader. Lancet 2005;365(9467):1301.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Full-text: ScienceDirect-Full Text PDF
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  • Abstract: ScienceDirect-Abstract & Full Text HTML
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  • Other: Lancet-Full Text PDF
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  • Journal Article Pozharny Y, Lambertini L, Ma Y, Ferrara L, Litton CG, Diplas A, Jacobs AR, Chen J, Stone JL, Wetmur J, Lee M-J. Genomic loss of imprinting in first-trimester human placenta. American Journal of Obstetrics & Gynecology 2010;202(4):391.e1-391.e8.
    abstract available   full text available
    R831711 (Final)
  • Abstract from PubMed
  • Abstract: AJOG-Abstract
    Exit
  • Journal Article Salama J, Chakraborty TR, Ng L, Gore AC. Effects of polychlorinated biphenyls on estrogen receptor-β expression in the anteroventral periventricular nucleus. Environmental Health Perspectives 2003;111(10):1278-1282.
    abstract available   full text available
    R831711 (2005)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
    R827039 (2002)
    R827039C002 (2002)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Journal Article Sarcinelli PN, Pereira AC, Mesquita SA, Oliveira-Silva JJ, Meyer A, Menezes MA, Alves SR, Mattos RC, Moreira JC, Wolff M. Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro. Environmental Research 2003;91(3):143-150.
    abstract available  
    R831711 (2005)
    R831711 (2007)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text HTML
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  • Other: ScienceDirect-Full Text PDF
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  • Journal Article Savitz DA, Janevic TM, Engel SM, Kaufman JS, Herring AH. Ethnicity and gestational diabetes in New York City, 1995–2003. BJOG-An International Journal of Obstetrics and Gynaecology 2008;115(8):969-978.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Full-text: Wiley Online-Full Text HTML
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  • Abstract: Wiley Online-Abstract
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  • Other: Wiley Online-Full Text PDF
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  • Journal Article Sheffield PE, Galvez MP. U.S. childhood obesity and climate change: moving toward shared environmental health solutions. Environmental Justice 2009;2(4):207-214.
    abstract available   full text available
    R831711 (Final)
  • Abstract: Liebert Online-Abstract
    Exit
  • Journal Article Stingone JA, Claudio L. Disparities in the use of urgent health care services among asthmatic children. Annals of Allergy, Asthma & Immunology 2006;97(2):244-250.
    abstract available   full text available
    R831711 (2005)
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Abstract: Annals of Allergy, Asthma & Immunology-Abstract
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  • Other: Science Direct - Abstract
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  • Journal Article Stingone JA, Claudio L. Asthma and enrollment in special education among urban schoolchildren. American Journal of Public Health 2006;96(9):1593-1598.
    abstract available   full text available
    R831711 (2007)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: American Journal of Public Health-Full Text HTML
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  • Abstract: American Journal of Public Health
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  • Other: American Journal of Public Health-PDF
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  • Journal Article Stingone JA, Claudio L. Disparities in use of urgent health care services among asthmatic children. Annals of Allergy, Asthma & Immunology 2006;97(2):244-250.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Full-text: Dr. Luz Claudio
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  • Abstract: Elsevier-Abstract
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  • Journal Article Stingone J, Claudio L. Disparities in allergy testing and health outcomes among urban children with asthma. Journal of Allergy and Clinical Immunology 2008;122(4):748-753.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
  • Abstract from PubMed
  • Full-text: Journal of Allergy and Clinical Immunology-Full Text HTML
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  • Abstract: Journal of Allergy and Clinical Immunology-Abstract
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  • Other: Journal of Allergy and Clinical Immunology-Full Text PDF
    Exit
  • Journal Article Suk WA, Ruchirawat KM, Balakrishnan K, Berger M, Carpenter D, Damstra T, Pronczuk de Garbino J, Koh D, Landrigan PJ, Makalinao I, Sly PD, Xu Y, Zheng BS. Environmental threats to children's health in Southeast Asia and the western Pacific. Environmental Health Perspectives 2003;111(10):1340-1347.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: EHP Full Text HTML
  • Abstract: EHP
  • Journal Article Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA, Galvez MP, Brenner BL, Wolff MS. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environmental Research 2008;106(2):257-269.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2007)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-Full Text PDF
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  • Journal Article Torres-Arreola L, Berkowitz G, Torres-Sanchez L, Lopez-Cervantes M, Cebrian ME, Uribe M, Lopez-Carrillo L. Preterm birth in relation to maternal organochlorine serum levels. Annals of Epidemiology 2003;13(3):158-162.
    abstract available  
    R831711 (2005)
    R831711 (2007)
  • Abstract from PubMed
  • Abstract: Annals of Epidemiology-Abstract
    Exit
  • Journal Article Trasande L, Landrigan PJ. The National Children's Study: a critical national investment. Environmental Health Perspectives 2004;112(14):A789-A790.
    abstract available   full text available
    R831711 (2005)
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    R831711C001 (2006)
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  • Journal Article Trasande L, Landrigan PJ, Schechter C. Public health and economic consequences of methyl mercury toxicity to the developing brain. Environmental Health Perspectives 2005;113(5):590-596.
    abstract available   full text available
    R831711 (2005)
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  • Journal Article Trasande L, Boscarino J, Graber N, Falk R, Schechter C, Galvez M, Dunkel G, Geslani J, Moline J, Kaplan-Liss E, Miller RK, Korfmacher K, Carpenter D, Forman J, Balk SJ, Laraque D, Frumkin H, Landrigan P. The environment in pediatric practice: a study of New York pediatricians' attitudes, beliefs, and practices towards children's environmental health. Journal of Urban Health 2006;83(4):760-772.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
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  • Abstract: SpringerLink
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  • Journal Article Trasande L, Schechter CB, Haynes KA, Landrigan PJ. Mental retardation and prenatal methylmercury toxicity. American Journal of Industrial Medicine 2006;49(3):153-158.
    abstract available   full text available
    R831711 (2005)
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    R831711 (Final)
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  • Abstract: Wiley Online-Abstract
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  • Journal Article Trasande L, Schapiro ML, Falk R, Haynes KA, Behrmann A, Vohmann M, Stremski ES, Eisenberg C, Evenstad C, Anderson HA, Landrigan PJ. Pediatrician attitudes, clinical activities, and knowledge of environmental health in Wisconsin. Wisconsin Medical Journal 2006;105(2):45-49.
    abstract available   full text available
    R831711 (2005)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Full-text: Wisconsin Medical Journal-Full Text PDF
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  • Journal Article Trasande L, Cronk CE, Leuthner SR, Hewitt JB, Durkin MS, McElroy JA, Anderson HA, Landrigan PJ. The National Children's Study and the children of Wisconsin. Wisconsin Medical Journal 2006;105(2):50-54.
    abstract available   full text available
    R831711 (2005)
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  • Abstract from PubMed
  • Full-text: Wisconsin Medical Journal PDF
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  • Journal Article Trasande L, Landrigan PJ, Schechter CB, Bopp RF. Methylmercury and the developing brain. Environmental Health Perspectives 2007;115(8):A396-A397.
    abstract available   full text available
    R831711 (2007)
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  • Abstract: EHP
  • Journal Article Wallenstein S, Chen J, Wetmur JG. Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Molecular Genetics and Metabolism 2006;89(3):270-273.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
    R831711C003 (2007)
  • Abstract from PubMed
  • Abstract: ScienceDirect-Abstract
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  • Journal Article Wetmur JG, Kumar M, Zhang L, Palomeque C, Wallenstein S, Chen J. Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes. Nucleic Acids Research 2005;33(8):2615-2619.
    abstract available   full text available
    R831711 (2005)
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    R831711C001 (2006)
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  • Full-text: Oxford Journals-Full Text HTML
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  • Abstract: Oxford Journals-Abstract
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  • Other: Oxford Journals-Full Text PDF
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  • Journal Article Wetmur JG, Chen J. Linking emulsion PCR haplotype analysis. Methods in Molecular Biology 2011;687(3):167-175.
    abstract available   full text available
    R831711 (Final)
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  • Journal Article Wolff MS. Half-lives of organochlorines (OCs) in humans. Archives of Environmental Contamination and Toxicology 1999;36(4):504 (Letter to the editor).
    full text available
    R831711 (2007)
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  • Abstract: Springer-Citation
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  • Journal Article Wolff MS, Anderson HA. Correspondence re: J. M. Schildkraut et al., environmental contaminants and body fat distribution. Cancer Epidemiol. Biomark. Prev., 8:179-183, 1999. Cancer Epidemiology Biomarkers & Prevention 1999;8(10):951-952.
    abstract available   full text available
    R831711 (2007)
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  • Other: Cancer Epidemiology, Biomarkers and Prevention-Full Text PDF
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  • Journal Article Wolff MS, Britton JA, Wilson VP. Environmental risk factors for breast cancer among African-American women. Cancer 2003;97(1 Suppl):289-310.
    abstract available   full text available
    R831711 (2005)
    R831711 (2007)
  • Abstract from PubMed
  • Full-text: Wiley Online-Full Text HTML
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  • Journal Article Wolff MS, Deych E, Ojo F, Berkowitz GS. Predictors of organochlorines in New York City pregnant women, 1998-2001. Environmental Research 2005;97(2):170-177.
    abstract available   full text available
    R831711 (2004)
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    R831711C001 (2006)
    R831711C002 (2004)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-Full Text PDF
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  • Journal Article Wolff MS, Britton JA, Russo JC. TCDD and puberty in girls. Environmental Health Perspectives 2005;113(1):A17.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
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  • Journal Article Wolff MS, Teitelbaum SL, Lioy PJ, Santella RM, Wang RY, Jones RL, Caldwell KL, Sjodin A, Turner WE, Li W, Georgopoulos P, Berkowitz GS. Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental Health Perspectives 2005;113(6):739-748.
    abstract available   full text available
    R831711 (2005)
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    R830827 (2004)
    R830827 (Final)
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  • Full-text: Environmental Health Perspectives-Full Text HTML
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  • Journal Article Wolff MS. Endocrine disruptors: challenges for environmental research in the 21st Century. Annals of the New York Academy of Sciences 2006;1076:228-238.
    abstract available   full text available
    R831711 (2006)
    R831711 (2007)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
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  • Journal Article Wolff MS, Engel S, Berkowitz G, Teitelbaum S, Siskind J, Barr DB, Wetmur J. Prenatal pesticide and PCB exposures and birth outcomes. Pediatric Research 2007;61(2):243-250.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C002 (2007)
    R831711C003 (2006)
    R831711C003 (2007)
  • Abstract from PubMed
  • Full-text: Nature-Full Text HTML
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  • Abstract: Nature-Abstract
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  • Other: Nature-Full Text PDF
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  • Journal Article Wolff MS, Teitelbaum SL, Windham G, Pinney SM, Britton JA, Chelimo C, Godbold J, Biro F, Kushi LH, Pfeiffer CM, Calafat AM. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environmental Health Perspectives 2007;115(1):116-121.
    abstract available   full text available
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
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    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
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  • Journal Article Wolff MS, Britton JA, Boguski L, Hochman S, Maloney N, Serra N, Liu Z, Berkowitz G, Larson S, Forman J. Environmental exposures and puberty in inner-city girls. Environmental Research 2008;107(3):393-400.
    abstract available   full text available
    R831711 (2007)
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  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Journal Article Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, Kushi LH, Erdmann C, Hiatt RA, Rybak ME, Calafat AM, Breast Cancer and Environment Research Centers. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environmental Health Perspectives 2010;118(7):1039-1046.
    abstract available   full text available
    R831711 (Final)
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  • Journal Article Wolff, MS, Engel SM, Berkowitz GS, Ye X, Silva MJ, Zhu C, Wetmur J, Calafat AM. Prenatal phenol and phthalate exposures and birth outcomes. Environmental Health Perspectives 2008;116(8):1092-1097.
    abstract available   full text available
    R831711 (2007)
    R831711 (Final)
    R831711C003 (2007)
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  • Associated PubMed link
  • Supplemental Keywords:

    lipase, paraoxonase, fast food, obesity, endocrine disruptors, neurodevelopment,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, POLLUTANTS/TOXICS, Environmental Chemistry, Health Risk Assessment, Chemicals, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Biochemistry, Children's Health, Endocrine Disruptors - Human Health, Risk Assessment, pesticide exposure, environmental health, childhood development, endocrine disrupting chemicals, exposure studies, pesticides, phtalates, Human Health Risk Assessment, children's vulnerablity, neurodevelopmental toxicity, exposure pathways, children's environmental health

    Progress and Final Reports:
    2004 Progress Report
    2005 Progress Report
    2006 Progress Report
    2007 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R831711C001 Growing Up Healthy in East Harlem (Community-Based Participatory Research)
    R831711C002 Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)
    R831711C003 Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)

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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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