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Extramural Research

Johns Hopkins Particulate Matter Research Center

EPA Grant Number: R832417
Center: Johns Hopkins Particulate Matter Research Center
Center Director: Samet, Jonathan M.
Title: Johns Hopkins Particulate Matter Research Center
Investigators: Samet, Jonathan M. , Breysse, Patrick , Chillrud, Steven , Dominici, Francesca , Garcia, Joe , Ondov, John M.
Institution: Johns Hopkins University , Columbia University (Lamont Doherty Earth Observatory) (JHPMRC) , University of Chicago , University of Maryland , Yale University
EPA Project Officer: Peffers, Mel
Project Period: October 1, 2005 through September 30, 2010
Project Amount: $7,993,275
RFA: Particulate Matter Research Centers (2004)
Research Category: Health Effects

Description:

Objective:

The Johns Hopkins PM Research Center brings together a multidisciplinary research team: biostatisticians, epidemiologists, exposure assessors, lung biologists and respiratory toxicologists, pulmonary clinicians, and atmospheric scientists to address the most critical gap in current understanding of health and particulate matter (PM) the physical and chemical characteristics that determine risk to human health. The Center's conceptual foundation lies in mapping health risks of PM across the US, based on analysis of national databases on air pollution, mortality, and hospitalization, and then using the maps to guide detailed monitoring and collection of PM samples for physical, chemical, and biological characterization in assays relevant to pulmonary and cardiovascular outcomes.

Approach:

The Center's three-phase agenda builds progressively from mapping the health risks in the first phase. During this first phase, we will also explore patterns of PM characteristics across the United States using existing data; we will develop protocols for detailed PM monitoring and collection of sufficient materials for bioassays; adapt existing in vitro and in vivo bioassays for assessing the comparative toxicity of the PM samples; and develop relevant microarray approaches. In the second phase, we will monitor and collect PM from 10 sites, selected from the higher and lower extremes of the effects of PM on human health; we will then assess the comparative toxicity of the PM samples in the bioassay battery. The third phase is likely to involve assessment of risks of more toxic particles in susceptible populations, source-related relative risk characterization, exposure assessment studies, and more focused studies of mechanisms of injury by these particles. The Center will have three discipline-based Research Projects and two scientific cores, the Data Base Core and the PM Collection, Sampling & Analysis Core. The Administrative Core will be the focal point for interdisciplinary interactions.

Expected Results:

The Center will map health risks of PM across the US, based on analysis of national databases on air pollution, mortality, and hospitalization, and then use the maps to guide detailed monitoring and collection of PM samples for physical, chemical, and biological characterization in assays relevant to pulmonary and cardiovascular outcomes.


Journal Articles: 44 Displayed | Download in RIS Format

Other center views: All 69 publications 46 publications in selected types All 44 journal articles

Type Citation Sub Project Document Sources
Journal Article Barr CD, Dominici F. Comment on article by Craigmile et al. Bayesian Analysis 2009;4(1):37-40. R832417C001 (2009)
  • Other: Bayesian Analysis
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  • Journal Article Barr CD, Dominici F. Cap and trade legislation for greenhouse gas emissions: public health benefits from air pollution mitigation. Journal of the American Medical Association 2010;303(1):69-70. R832417 (Final)
    R832417C001 (Final)
    R833622 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: JAMA abstract
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  • Journal Article Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality and the adequacy of current ozone regulations. Environmental Health Perspectives 2006;114(4):532-536. R832417 (Final)
    R832417C001 (2006)
    R832417C001 (2007)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (Final)
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  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Environmental Health Perspectives-Full Text HTML
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  • Journal Article Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environmental Health Perspectives 2007;115(7):989-995. R832417 (Final)
    R832417C001 (2006)
    R832417C001 (2007)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (Final)
  • Abstract from PubMed
  • Full-text: EHP
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  • Other: EHP PDF
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  • Journal Article Bell ML, Kim JY, Dominici F. Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environmental Health Perspectives 2007;115(11):1591-1595. R832417 (Final)
    R832417C001 (2007)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Environmental Health Perspectives-Full Text HTML
  • Journal Article Bell ML, Dominici F. Effect modification by community characteristics on the short-term effects of ozone exposure and mortality in 98 US communities. American Journal of Epidemiology 2008;167(8):986-997. R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: American Journal of Epidemiology-Full Text HTML
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  • Abstract: American Journal of Epidemiology
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  • Other: American Journal of Epidemiology-Full Text PDF
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  • Journal Article Bell ML, Ebisu K, Peng RD, Walker J, Samet JM, Zeger SL, Dominici F. Seasonal and regional short-term effects of fine particles on hospital admissions in 202 US counties, 1999-2005. American Journal of Epidemiology 2008;168(11):1301-1310. R832417 (2008)
    R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: American Journal of Epidemiology-Full Text HTML
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  • Abstract: American Journal of Epidemiology-Abstract
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  • Other: American Journal of Epidemiology-Full Text PDF
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  • Journal Article Bell ML, Ebisu K, Peng RD, Samet JM, Dominici F. Hospital admissions and chemical composition of fine particle air pollution. American Journal of Respiratory and Critical Care Medicine 2009;179(12):1115-1120. R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833863 (2009)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: AJRCCM - Full Text HTML
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  • Abstract: AJRCCM - Abstract
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  • Other: AJRCCM - PDF
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  • Journal Article Bell ML, Peng RD, Dominici F, Samet JM. Emergency hospital admissions for cardiovascular diseases and ambient levels of carbon monoxide: results for 126 United States urban counties, 1999-2005. Circulation 2009;120(11):949-955. R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833863 (2009)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: Circulation - Full Text HTML
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  • Abstract: Circulation - Abstract
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  • Other: Circulation - PDF
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  • Journal Article Bell ML, Ebisu K, Peng RD, Dominici F. Adverse health effects of particulate air pollution: modification by air conditioning. Epidemiology 2009;20(5):682-686. R832417 (Final)
    R832417C001 (Final)
    R833863 (2009)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Epidemiology - Abstract
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  • Journal Article Bell ML, Ebisu K, Peng RD. Community-level spatial heterogeneity of chemical constituent levels of fine particulates and implications for epidemiological research. Journal of Exposure Science and Environmental Epidemiology 2011;21(4):372-384 R832417 (Final)
    R832417C001 (Final)
  • Abstract from PubMed
  • Full-text: Nature.Com-Full Text HTML
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  • Abstract: Journal of Exposure Science and Environmental Epidemiology-Abstract
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  • Journal Article Chang HH, Peng RD, Dominici F. Estimating the acute health effects of coarse particulate matter accounting for exposure measurement error. Biostatistics 2011;12(4):637-652. R832417 (Final)
    R832417C001 (Final)
    R832416 (Final)
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  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Oxford Journals-Abstract
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  • Journal Article Crainiceanu CM, Dominici F, Parmigiani G. Adjustment uncertainty in effect estimation. Biometrika 2008;95(3):635-651. R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
  • Abstract: Biometrika Abstract
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  • Journal Article Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. Journal of the American Medical Association 2006;295(10):1127-1134. R832417 (Final)
    R832417C001 (2006)
    R832417C001 (2007)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (2005)
  • Abstract from PubMed
  • Full-text: JAMA
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  • Other: JAMA PDF
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  • Journal Article Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives 2007;115(12):1701-1703. R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: EHP Full Text
  • Journal Article Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Dominici et al. respond to ‘‘Heterogeneity of particulate matter health risks.’’ American Journal of Epidemiology 2007;166(8):892-893. R832417 (2008)
    R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
  • Full-text: American Journal of Epidemiology-Full Text HTML
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  • Abstract: American Journal of Epidemiology-Abstract
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  • Other: American Journal of Epidemiology PDF
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  • Journal Article Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? American Journal of Epidemiology 2007;166(8):880-888. R832417 (Final)
    R832417C001 (2007)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (Final)
    R833622 (2008)
    R833622 (2009)
  • Abstract from PubMed
  • Full-text: Oxford Journals-Full Text HTML
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  • Abstract: Oxford Journals-Abstract
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  • Other: Oxford Journals-PDF
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  • Journal Article Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008;19(4):558-560. R832417 (2008)
    R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
  • Abstract from PubMed
  • Full-text: Epidemiology-Full Text HTML
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  • Journal Article Dominici F, Peng RD, Barr CD, Bell ML. Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach. Epidemiology 2010;21(2):187-194. R832417 (Final)
    R832417C001 (Final)
  • Abstract from PubMed
  • Abstract: Epidemiology Abstract
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  • Journal Article Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality: a comparison of the six cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology 2008;19(2):209-216. R832417 (2008)
    R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (2008)
    R833622 (2009)
  • Abstract from PubMed
  • Full-text: Johns Hopkins University-PDF
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  • Abstract: Epidemiology-Abstract
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  • Journal Article Han I, Ramos-Bonilla JP, Rule AM, Mihalic JN, Polyak LM, Breysse PN, Geyh AS. Comparison of spatial and temporal variations in p-PAH, BC, and p-PAH/BC ratio in six US counties. Atmospheric Environment 2011;45(40):7644-7652. R832417 (Final)
    R832417C002 (Final)
  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-PDF
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  • Journal Article Janes H, Dominici F, Zeger S. Partitioning evidence of association between air pollution and mortality. Epidemiology 2007;18(4):427-428 (author's response). R832417 (2008)
    R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (2008)
    R833622 (2009)
    R833622 (Final)
  • Full-text: Epidemiology-Full Text HTML
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  • Other: Epidemiology-TOC Link to PDF
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  • Journal Article Janes H, Dominici F, Zeger SL. Trends in air pollution and mortality: an approach to the assessment of unmeasured confounding. Epidemiology 2007;18(4):416-423. R832417 (Final)
    R832417C001 (2006)
    R832417C001 (2007)
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    R832417C001 (Final)
    R830548 (Final)
    R833622 (Final)
  • Abstract from PubMed
  • Full-text: Full-text PDF
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  • Journal Article Janes H, Dominici F, Zeger S. On quantifying the magnitude of confounding. Biostatistics 2010;11(3):572-582. R832417 (Final)
    R832417C001 (Final)
  • Abstract from PubMed
  • Abstract: Biostatistics-Abstract
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  • Journal Article Peng RD, Dominici F, Louis TA. Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Society: Series A (Statistics in Society) 2006;169(2):179-203. R832417C001 (2006)
    R832417C001 (2007)
    R832417C001 (2008)
    R830548 (Final)
  • Full-text: Full-text pdf
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  • Abstract: Wiley Interscience
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  • Journal Article Peng RD, Dominici F, Zeger SL. Reproducible epidemiological research. American Journal of Epidemiology 2006;163(9):783-789. R832417 (Final)
    R832417C001 (2006)
    R832417C001 (2007)
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    R830548 (Final)
  • Abstract from PubMed
  • Full-text: Oxford Journals
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  • Other: Oxford Journals PDF
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  • Journal Article Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. Journal of the American Medical Association 2008;299(18):2172-2179. R832417 (2008)
    R832417 (Final)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (2008)
    R833622 (2009)
    R833622 (Final)
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  • Full-text: JAMA-Full Text HTML
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  • Abstract: JAMA-Abstract
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  • Other: JAMA-PDF
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  • Journal Article Peng RD. A Method for Visualizing Multivariate Time Series Data. Journal of Statistical Software 2008;25(Code Snippet 1):1-17 R832417 (2008)
    not available
    Journal Article Peng RD, Dominici F, Welty LJ. A Bayesian hierarchical distributed lag model for estimating the time course of risk of hospitalization associated with particulate matter air pollution. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2009;58(1):3-24. R832417 (2008)
    R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (Final)
  • Abstract: Wiley Online-Abstract
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  • Other: Prepublication paper
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  • Journal Article Peng RD, Bell ML, Geyh AS, McDermott A, Zeger SL, Samet JM, Dominici F. Emergency admissions for cardiovascular and respiratory diseases and the chemical composition of fine particle air pollution. Environmental Health Perspectives 2009;117(6):957-963. R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (Final)
    R833863 (2009)
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  • Abstract from PubMed
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  • Journal Article Peng RD, Bell ML. Spatial misalignment in time series studies of air pollution and health data. Biostatistics 2010;11(4):720-740. R832417 (Final)
    R832417C001 (Final)
  • Abstract from PubMed
  • Abstract: Biostatistics-Abstract
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  • Journal Article Ramos-Bonilla JP, Breysse PN, Dominici F, Geyh A, Tankersley CG. Ambient air pollution alters heart rate regulation in aged mice. Inhalation Toxicology 2010;22(4):330-339. R832417 (Final)
    R832417C002 (Final)
  • Abstract from PubMed
  • Abstract: Informa healthcare-Abstract
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  • Journal Article Rava M, White R, Dominici F. Does attainment status for the PM10 National Air Ambient Quality Standard change the trend in ambient levels of particulate matter? Air Quality, Atmosphere and Health 2011;4(2):133-143. R832417 (Final)
    R832417C001 (Final)
    R833622 (2009)
    R833622 (Final)
  • Abstract: SpringerLink-Abstract
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  • Journal Article Samet JM. Air pollution risk estimates: Determinants of heterogeneity. Journal of Toxicology and Environmental Health-Part A-Current Issues 2008;71(9-10):578-582 R832417 (2008)
    not available
    Journal Article Symons JM, Wang L, Guallar E, Howell E, Dominici F, Schwab M, Ange BA, Samet J, Ondov J, Harrison D, Geyh A. A case-crossover study of fine particulate matter air pollution and onset of congestive heart failure symptom exacerbation leading to hospitalization. American Journal of Epidemiology 2006;164(5):421-433. R832417 (Final)
    R832417C001 (2006)
    R832417C001 (2007)
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  • Abstract from PubMed
  • Full-text: Oxford Journals
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  • Other: Oxford Journals PDF
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  • Journal Article Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwartz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health-Part A 2007;70(3-4):311-315. R832417 (Final)
    R832417C001 (2007)
    R832417C001 (2008)
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    R832417C001 (Final)
    R830548 (Final)
    R831861 (2005)
  • Abstract from PubMed
  • Abstract: Taylor&Francis-Abstract
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  • Other: ResearchGate-Abstract
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  • Journal Article Venturini S, Dominici F, Parmigiani G. Gamma shape mixtures for heavy-tailed distributions. The Annals of Applied Statistics 2008;2(2):756-776. R832417 (2007)
  • Full-text: Project Euclid PDF
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  • Abstract: Project Euclid
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  • Journal Article Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JGN. Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environmental Health Perspectives 2008;116(11):1500-1508. R832417 (2008)
    R832417 (Final)
    R832417C003 (2008)
    R832417C003 (2009)
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  • Full-text: EHP Full Text HTML
  • Abstract: EHP
  • Journal Article Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JGN. Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. American Journal of Respiratory Cell and Molecular Biology 2010;42(4):442-449. R832417 (Final)
    R832417C003 (2009)
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  • Full-text: American Journal of Respiratory Cell and Molecular Biology-Full Text HTML
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  • Abstract: American Journal of Respiratory Cell and Molecular Biology
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  • Other: American Journal of Respiratory Cell and Molecular Biology-Full Text PDF
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  • Journal Article Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, Moreno-Vinasco L, Mathew B, Natarajan V, Garcia JG. Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation. American Journal of Respiratory Cell and Molecular Biology 2012;47(4):491-496. R832417 (Final)
    R832417C003 (Final)
  • Abstract from PubMed
  • Abstract: AJRCMB-Abstract
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  • Journal Article Welty LJ, Peng RD, Zeger SL, Dominici F. Bayesian distributed lag models: estimating effects of particulate matter air pollution on daily mortality. Biometrics 2009;65(1):282-291. R832417 (2008)
    R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (Final)
  • Abstract from PubMed
  • Full-text: Johns Hopkins University PDF
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  • Abstract: Wiley Online-Abstract
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  • Journal Article Zeger SL, Dominici F, McDermott A, Samet JM. Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000–2005). Environmental Health Perspectives 2008;116(12):1614-1619. R832417 (2008)
    R832417 (2009)
    R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (2008)
    R833622 (2009)
    R833622 (Final)
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  • Full-text: Environmental Health Perspectives-Full Text HTML
  • Abstract: Environmental Health Perspectives
  • Journal Article Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T, Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JGN, Natarajan V. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2009;40(1):19-30. R832417 (2008)
    R832417 (Final)
    R832417C003 (2008)
    R832417C003 (2009)
  • Abstract from PubMed
  • Full-text: American Journal of Respiratory Cell and Molecular Biology
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  • Abstract: American Journal of Respiratory Cell and Molecular Biology
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  • Other: American Journal of Respiratory Cell and Molecular Biology
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  • Journal Article Zhou Y, Dominici F, Louis TA. Racial disparities in risks of mortality in a sample of the US Medicare population. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2010;59(2):319-339. R832417 (2007)
  • Abstract: Wiley Online-Abstract
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  • Other: Prepublication paper
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  • Supplemental Keywords:

    PM Components, susceptible populations, human health risks, toxicological and genomic bioassays,, RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, atmospheric particulate matter, cardiopulmonary responses, chemical characteristics, epidemiology, human health effects, toxicology, lung epithelial cells, cardiovascular vulnerability, exposure, airborne particulate matter, pulmonary toxicity, particle exposure, biological mechanisms, endothelial function, pariculate matter, cardiopulmonary mechanisms, human exposure, particulate exposure, ambient particle health effects, ultrafine particulate matter, respiratory impact, PM, cardiotoxicity, particulate matter components, cardiovascular disease, human health risk

    Progress and Final Reports:
    2006 Progress Report
    2007 Progress Report
    2008 Progress Report
    2009 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R832417C001 Estimation of the Risks to Human Health of PM and PM Components
    R832417C002 PM Characterization and Exposure Assessment (Project 2)
    R832417C003 Biological Assessment of the Toxicity of PM and PM Components

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