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Grantee Research Project Results

Grantee Research Project Results

Associations Between Ambient Levels of Air Pollution and Lung Function in Adults From 20 European Cities

EPA Grant Number: FP916371
Title: Associations Between Ambient Levels of Air Pollution and Lung Function in Adults From 20 European Cities
Investigators: Gotschi, Thomas
Institution: University of Southern California
EPA Project Officer: Zambrana, Jose
Project Period: January 1, 2004 through December 31, 2006
Project Amount: $111,344
RFA: STAR Graduate Fellowships (2004)
Research Category: Fellowship - Public Health Sciences , Academic Fellowships , Health Effects



The objective of this research project is to investigate whether various aspects of ambient urban air pollution are associated with lung function within the European Community Respiratory Health Survey (ECRHS).


ECRHS is the largest European cohort study on respiratory diseases, with 21 study centers and a 10-year followup period. The air pollution exposure assessment consists of central measurements of NO2 (nitrogen dioxide), PM2.5 (particulate matter with a median aerodynamic diameter of 2.5µm), and a variety of its characteristics (elements, reflectance, oxidative properties) over a 1-year period in each study center.

First, a set of comparable estimates of long-term population mean exposures to air pollution will be compiled, taking into account the influence of the local characteristics of the ECRHS sampling locations on the levels of various pollutants. Information on proximity to traffic, indicators of local traffic, and comparisons between centrally measured NO2 levels and levels of subsamples of the ECRHS participants’ homes will be used.

Second, data on forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) of approximately 6,500 adults from 21 ECRHS communities will be used to investigate associations between pulmonary function and the derived mean ambient air quality levels of the respective cities.

This project will provide insight into the relevance of sampling locations for the measurements of various air pollution indicators. The analysis of the associations between several air pollution indicators and lung function will contribute to the identification and understanding of the health-relevant fractions of air pollution.

Supplemental Keywords:

fellowship, air pollution, lung function, particulate matter, PM, PM2.5 characteristics, urban air pollution, sampling location, cohort study, European Community Respiratory Health Survey, respiratory disease,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, acute cardiovascular effects, airway disease, exposure, epidemelogy, airborne particulate matter, forced vital capacity, human exposure, ambient particle health effects, blood viscosity, epidemiological studies, concentrated air particles, European Countries, aersol particles

Relevant Websites:

2004 STAR Graduate Fellowship Conference Poster (PDF, 1p., 825KB, about PDF)

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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