Research Grants/Fellowships/SBIR

2004 Progress Report: Endocrine Disrupting Chemicals and Thyroid Outcomes

EPA Grant Number: R830254
Title: Endocrine Disrupting Chemicals and Thyroid Outcomes
Investigators: Anderson, Henry A.
Institution: Wisconsin Department of Health and Family Services
EPA Project Officer: Glenn, Barbara
Project Period: March 1, 2003 through February 28, 2007 (Extended to February 28, 2009)
Project Period Covered by this Report: March 1, 2004 through February 28, 2005
Project Amount: $2,288,208
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001) RFA Text |  Recipients Lists
Research Category: Economics and Decision Sciences , Endocrine Disruptors , Health , Safer Chemicals



The overall objective of this research project is to measure polychlorinated biphenyls and polybrominated diphenyl ether levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and Hemoglobin A1C in 500 frequent and infrequent sport fish consumers. Based on the project findings, the specific objective of this research project is to determine whether there is an interaction between fish consumption and endocrine function.

Progress Summary:

The first phase of the study is almost complete. A screener questionnaire was mailed to a sample cohort of 3,695. Two hundred additional respondents, not previously contacted because of participation in another study, will be recruited as part of this first phase. As a result of a low response rate of 48 percent, a nonresponders survey was developed and administered to a sample of 524 nonresponders. These data are still to be delivered by the contractor and will be compared with responders.

The second phase of the study has begun. More than 600 respondents have volunteered to participate by providing blood and urine samples and completing a more detailed health status and fish consumption questionnaire. Laboratory analysis of the samples has begun as well with three separate laboratories conducting analysis for lipid levels, endocrine and thyroid function, and chemical contaminant levels.

Future Activities:

We will complete phase two of the data and specimen collection and continue having the three laboratories conduct blood and urine analysis. A subset of laboratory results, with Institutional Review Board approval, will be sent to respondents once all results are available.

Preliminary analysis of screener data will begin, as well as simple comparisons of fish consumption and health status data, with the original 1993-1994 study.

Journal Articles on this Report : 1 Displayed | Download in RIS Format

Other project views: All 54 publications 26 publications in selected types All 25 journal articles
Type Citation Project Document Sources
Journal Article Turyk M, Anderson HA, Hanrahan LP, Falk C, Steenport DN, Needham LL, Patterson Jr. DG, Freels S, Persky V, Great Lakes Consortium. Relationship of serum levels of individual PCB, dioxin, and furan congeners and DDE with Great Lakes sport-caught fish consumption. Environmental Research 2006;100(2):173-183. R830254 (2004)
R830254 (2005)
R830254 (2006)
R830254 (2007)
R830254 (Final)
  • Abstract from PubMed
  • Full-text: Science Direct
  • Abstract: Science Direct
  • Other: Science Direct PDF
  • Supplemental Keywords:

    endocrine, PCB, PBDE, thyroid, sport fish, PCB levels, PBDE levels, thyroid parameters, reproductive hormone levels, fish consumption, endocrine function, blood samples, urine samples, thyroid function, lipid levels,, RFA, Health, Scientific Discipline, POLLUTANTS/TOXICS, HUMAN HEALTH, Health Risk Assessment, Exposure, Chemicals, Epidemiology, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Risk Assessments, Biochemistry, Molecular Biology/Genetics, Endocrine Disruptors - Human Health, pesticide exposure, chemical exposure, fish, bioavailability, endocrine disrupting chemicals, exposure studies, PCBs, altered sexual development, fish consumption, hormone degradation, DDT, human exposure, human growth and development, PCB, reproductive processes, thyroid function, groundwater contamination, thyroid, dietary exposure, agrochemicals, epidemiologic studies, Great Lakes, human health risk

    Progress and Final Reports:
    Original Abstract
    2003 Progress Report
    2005 Progress Report
    2006 Progress Report
    2007 Progress Report
    Final Report