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Extramural Research

2003 Progress Report: Endocrine Disrupting Chemicals and Thyroid Outcomes

EPA Grant Number: R830254
Title: Endocrine Disrupting Chemicals and Thyroid Outcomes
Investigators: Anderson, Henry A.
Institution: Wisconsin Department of Health and Family Services
EPA Project Officer: Glenn, Barbara
Project Period: March 1, 2003 through February 28, 2007 (Extended to February 28, 2009)
Project Period Covered by this Report: March 1, 2003 through February 28, 2004
Project Amount: $2,288,208
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001)
Research Category: Economics and Decision Sciences , Endocrine Disruptors



The overall objective of this research project is to measure polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and hemoglobin A1C in 500 frequent and infrequent sport fish consumers. Based on the study findings, the specific objective of this research project is to determine whether there is an interaction between fish consumption and endocrine function.

Progress Summary:

Our progress to date includes completing the U.S. Environmental Protection Agency Quality Assurance Project Plan for all data and laboratory components, confirming the mailing addresses of our cohort members, and developing the survey instruments that will be used to collect health and fish consumption data. These surveys, along with a cover letter and consent form, have been submitted to our local Internal Review Board for approval. The laboratory also has completed validation of PBDE analytic methods, and has refined model sensitivity.

Future Activities:

We will begin mailing surveys to 3,600 individuals in the spring of 2004; biological sample collection will begin in the spring/summer of 2004. We will recruit at least 500 participants to donate blood and urine specimens. We will continue to measure PCB and PBDE levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and hemoglobin A1C in 500 frequent and infrequent sport fish consumers. We also will use survey and laboratory data to publish peer-reviewed scientific articles and revise state fish advisories.

Journal Articles:

No journal articles submitted with this report: View all 54 publications for this project

Supplemental Keywords:

groundwater, human health effects, age, race, sex, diet, epidemiology, monitoring, analytical techniques, human health, health, physical aspects, pollutants, toxics, biochemistry, chemicals, endocrine disruptors, environmental exposure and risk, exposure, health risk assessment, molecular biology, risk assessments, dichlorodiphenyltrichloroethane, DDT, Great Lakes, polychlorinated biphenyls, PCBs, agrochemicals, chemical exposure, dietary exposure, endocrine disrupting chemicals, epidemiologic studies, exposure studies, fish, fish consumption, human exposurehuman health risk, pesticide exposure, thyroid, endocrine, polybrominated diphenyl ethers, PBDEs, sport fish,, RFA, Health, Scientific Discipline, POLLUTANTS/TOXICS, HUMAN HEALTH, Health Risk Assessment, Exposure, Chemicals, Epidemiology, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Risk Assessments, Biochemistry, Molecular Biology/Genetics, Endocrine Disruptors - Human Health, pesticide exposure, chemical exposure, fish, bioavailability, endocrine disrupting chemicals, exposure studies, PCBs, altered sexual development, fish consumption, hormone degradation, DDT, human exposure, human growth and development, PCB, reproductive processes, thyroid function, groundwater contamination, thyroid, dietary exposure, agrochemicals, epidemiologic studies, Great Lakes, human health risk

Progress and Final Reports:
Original Abstract
2004 Progress Report
2005 Progress Report
2006 Progress Report
2007 Progress Report
Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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