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Extramural Research

Center for Child Environmental Health Risks Research

EPA Grant Number: R826886
Center: University of Washington
Center Director: Faustman, Elaine
Title: Center for Child Environmental Health Risks Research
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through December 31, 2003
Project Amount: $3,545,396
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects , Human Health

Description:

Objective:

The theme of the University of Washington based Center for Child Environmental Health Risks Research (CHC) is understanding the biochemical, molecular and exposure mechanisms that define children's susceptibility to pesticides and the implications for assessing pesticide risks to normal development and learning.  The CHC is a multi-disciplinary research center that takes advantage of the established landscape of risk research at the University of Washington; it is administratively housed within the Institute for Risk Analysis and Risk Communication that is in the UW's School of Public Health and Community Medicine..

To facilitate both basic and applied research on reducing the adverse effects of environmental pesticide exposures, center participants include members from multiple institutions, schools, and varied departments and clinics.  To achieve tangible effects on the community, the CHC includes a partnership with an eastern Washington community within the Yakima Valley agricultural center of our state, to jointly accomplish pesticide intervention with reduced childhood pesticide exposures.

The CHC is comprised of two laboratory based research projects, two field based projects, and four facility cores.  The specific objectives of the laboratory based research projects are to:

  • identify cellular, biochemical and molecular mechanisms for the adverse developmental neurotoxicity of pesticides and
  • identify the impact of genetic polymorphisms for paraoxonase on the developmental neurotoxicity of organophosphate pesticides.

The specific objectives of the two field based projects-a pesticide exposure pathways research project plus the related community based intervention study are to:

  • identify critical pathways of pesticide exposure for children and
  • to develop a culturally-appropriate intervention to break the take-home pathway that will ultimately result in reducing children's exposure to pesticides.

The four facility cores (Neurobehavioral Assessment, Exposure Assessment, Risk Characterization and Risk Communication) are designed to support the research agenda and to put the research into a child specific risk assessment context.  Thus the scientific findings on pesticide toxicity and exposure can be directly incorporated into risk assessment models that are designed to protect child health.  A diagram of the center's organizational structure follows.

Laboratory Based Projects

The laboratory based projects in this proposal will specifically address two aspects of children's susceptibility to pesticides.  They will investigate molecular mechanisms of neurotoxicity for pesticides and evaluate the role of paraoxonase in defining sensitivity of children to organophosphate pesticides.  Functional assessments for both studies will be performed in the Neurobehavioral Assessment Facility Core.  These projects will be closely linked as common organophosphate pesticides will be examined in all projects, animals, and tissues and research results will be readily shared among these researchers.


Journal Articles: 73 Displayed | Download in RIS Format

Other center views: All 86 publications 76 publications in selected types All 73 journal articles

Type Citation Sub Project Document Sources
Journal Article Andersen ME, Conolly RB, Faustman EM, Kavlock RJ, Portier CJ, Sheehan DM, Wier PJ, Ziese L. Quantitative mechanistically based dose-response modeling with endocrine-active compounds. Environmental Health Perspectives 1999;107(Suppl 4):631-638. R826886 (2000)
not available
Journal Article Bartell SM, Ponce RA, Takaro TK, Zerbe RO, Omenn GS, Faustman EM. Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Analysis 2000;20(1):87-99. R826886 (2000)
not available
Journal Article Bogdanffy MS, Daston G, Faustman EM, Kimmel CA, Kimmel GL, Seed J,Vu V. Harmonization of cancer and non-cancer risk assessment:proceedings of a consensus-building workshop. Toxicological Science 2001;61(1):18-31. R826886 (2000)
not available
Journal Article Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 2000;10(5):453-460. R826886 (2000)
not available
Journal Article Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436.
abstract available   full text available
R826886 (2000)
R826886C002 (2001)
R831709 (2007)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: AJHG Full Text
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  • Other: AJHG PDF
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  • Journal Article Brophy VH, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001;11(1):77-84.
    abstract available   full text available
    R826886 (2000)
    R826886C002 (2001)
  • Abstract from PubMed
  • Full-text: Pharmacogenetics Full Text
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  • Other: Pharmacogenetics PDF
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  • Journal Article Burbacher TM, Grant KS. Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicology and Teratology 2000;22(4):475-486. R826886 (2000)
    not available
    Journal Article Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. Journal of Neuroscience 2001;21(2):434-443. R826886 (2000)
    not available
    Journal Article Chan GC, Lernmark U, Xia Z, Storm DR. DNA elements of the type 1 adenylyl cyclase gene locus enhance reporter gene expression in neurons and pinealocytes. European Journal of Neuroscience 2001;13(11):2054-2066. R826886 (2000)
    not available
    Journal Article Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chemico–Biological Interactions 1999;119-120:429-438.
    abstract available   full text available
    R826886 (2000)
    R826886C002 (2000)
  • Abstract from PubMed
  • Full-text: Science Direct Full Text
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  • Other: Science Direct PDF
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  • Journal Article Costa LG. The emerging field of ecogenetics. Neurotoxicology 2000;21(1-2):85-89.
    abstract available  
    R826886 (2000)
    R826886C002 (2000)
  • Abstract from PubMed
  • Journal Article Costa LG, Guizzetti M, Lu H, Bordi F, Vitalone A, Tita B, Palmery M, Valeri P, Silvestrini B. Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology 2001;160(1-3):19-26. R826886 (2000)
    not available
    Journal Article Costa LG. Pesticide exposure:differential risk for neurotoxic outcomes due to enzyme polymorphisms. Clinics in Occupational and Environmental Medicine 2001;1:511-523. R826886 (2000)
    not available
    Journal Article Costa LG, Guizzetti M, Burry , Oberdoerster J. Developmental neurotoxicity:do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. Toxicology Letters 2002;127(1-3):197-205. R826886 (2000)
    not available
    Journal Article Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12.
    abstract available  
    R826886 (2000)
    R826886C002 (2002)
    R831709 (2005)
    R831709 (2007)
    R831709C002 (2004)
  • Abstract from PubMed
  • Abstract: Inform healthcare-Abstract
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  • Journal Article Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms:effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-392.
    abstract available  
    R826886C002 (2002)
    R831709 (2005)
    R831709 (2007)
    R831709C002 (2004)
  • Abstract from PubMed
  • Abstract: Annual Reviews-Abstract
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  • Journal Article Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TF, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002;110(12):A787-792.
    abstract available   full text available
    R826886 (2000)
    R826886C003 (2001)
    R826886C003 (2002)
    R826886C004 (2001)
    R826886C004 (2002)
  • Abstract from PubMed
  • Full-text: Environmental Health Perspectives Full Text
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  • Other: Environmental Health Perspectives PDF
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  • Journal Article Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122.
    abstract available   full text available
    R826886 (2000)
    R826886C004 (2002)
    R831709 (2005)
    R831709 (2007)
  • Full-text from PubMed
  • Abstract from PubMed
  • Journal Article Faustman EM, Lewandowski TA, Ponce RA, Bartell SM. Biologically based dose-response models for developmental toxicants:lessons from methylmercury. Inhalation Toxicology 1999;11(6-7):559-572. R826886 (2000)
    not available
    Journal Article Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children's susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21.
    abstract available   full text available
    R826886 (2000)
    R825173 (1999)
    R825173 (2000)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate - Abstract & Full Text - PDF
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  • Journal Article Faustman EM, Ponce RA, Ou YC, Mendoza MA, Lewandowski T, Kavanagh T. Investigations of methylmercury-induced alterations in neurogenesis. Environmental Health Perspectives 2002;110(Suppl 5):859-864. R826886 (2000)
    not available
    Journal Article Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 2000;108(6):515-520.
    abstract available   full text available
    R826886 (2000)
    R826886C004 (2001)
  • Abstract from PubMed
  • Full-text: Environmental Health Perspectives Full Text
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  • Other: Environmental Health Perspectives PDF
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  • Journal Article Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC. Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Suppl 2):662-671.
    abstract available   full text available
    R826886 (2000)
    R826886C004 (2001)
    R825171 (2000)
  • Abstract from PubMed
  • Other: NATURE PDF
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  • Journal Article Fenske RA, Kedan G, Lu C, Fisker-Andersen JA, Curl CL. Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. Journal of Exposure Analysis and Environmental Epidemiology 2002;12(1):21-28. R826886 (2000)
    not available
    Journal Article Fenske RA, Lu C, Barr D, Needham L. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environmental Health Perspectives 2002;110(5):549-553. R826886 (2000)
    not available
    Journal Article Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z. Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. Journal of Neuroscience2001;21(13):4657-4667. R826886 (2000)
    not available
    Journal Article Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000;21(1-2):91-100.
    abstract available  
    R826886 (2000)
    R826886C002 (2000)
    R826886C002 (2001)
  • Abstract from PubMed
  • Journal Article Furlong CE. PON1 status and neurologic symptom complexes in Gulf War veterans. Genome Research 2000;10(2):153-155. R826886 (2000)
    not available
    Journal Article Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. Neurotoxicology 2000;21(4):581-587.
    abstract available  
    R826886 (2000)
    R826886C002 (2001)
  • Abstract from PubMed
  • Journal Article Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG. Genetic factors in susceptibility:serum PON1 variation between individuals and species. Human and Ecological Risk Assessment 2002;8(1):31-43.
    abstract available   full text available
    R826886 (2000)
    R826886C002 (2002)
  • Abstract: Ingenta Connect Abstract
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  • Other: Science Direct PDF
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  • Journal Article Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002;3(3):341-348.
    abstract available  
    R826886 (2000)
    R826886C002 (2002)
  • Abstract from PubMed
  • Journal Article Garlock TJ, Shirai JH, Kissel JC. Adult responses to a survey of soil contact-related behaviors. Journal of Exposure Analysis and Environmental Epidemiology 1999;9(2):134-142. R826886 (2000)
    not available
    Journal Article Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. Journal of Cell Biology 2000;150(2):335-47. R826886 (2000)
    not available
    Journal Article Gohlke JM, Griffith WC, Bartell SM, Lewandowski TA, Faustman EM. A computational model for neocortical neuronogenesis predicts ethanol-induced neocortical neuron number deficits. Developmental Neuroscience 2002;24(6):467-477. R826886 (2000)
    not available
    Journal Article Goldstein BD, Erdal S, Burger J, Faustman EM, Friedlander BR, Greenberg M, Leschine TM, Powers CW, Waishwell L, Williams B. Stakeholder participation:Experience from the CRESP program. Environmental Epidemiology and Toxicology 2000;2:103-111. R826886 (2000)
    not available
    Journal Article Hetman M, Kanning KC, Smith-Cavanaugh JE, Xia Z. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular-signal-regulated kinase and phosphatidylinositol-3 kinase. Journal of Biological Chemistry 1999;(274):22569-22580. R826886 (2000)
    not available
    Journal Article Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. Journal of Neuroscience 2000;20(7):2567-2574. R826886 (2000)
    not available
    Journal Article Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, Schellenberg GD, Furlong CE. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arteriosclerosis, Thrombosis, and Vascular Biology 2000;20(11):2441-2447. R826886 (2000)
    not available
    Journal Article Judd NL, Griffith WC, Ylitalo GM, Faustman EM. Alternative strategies for PCB risk reduction from contaminated seafood:options for children as susceptible populations. Bulletin of Environmental Contaminants and Toxicology 2002;69:847-854. R826886 (2000)
    not available
    Journal Article Koch D, Lu CS, Fisker-Andersen J, Jolley L, Fenske RA. Temporal association of children's pesticide exposure and agricultural spraying: Report of a longitudinal biological monitoring study. Environmental Health Perspectives 2002;110(8):829-833.
    abstract available  
    R826886 (2000)
    R825171 (2000)
    not available
    Journal Article Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg M. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 2002;34:221-233. R826886 (2000)
    not available
    Journal Article Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM. Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. Teratology 2002;66(5):235-241. R826886 (2000)
    R825358 (Final)
    not available
    Journal Article Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in- vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000;10(9):767-779.
    abstract available  
    R826886 (2000)
    R826886C002 (2000)
    R826886C002 (2001)
  • Abstract from PubMed
  • Journal Article Little SA, Mirkes PE. Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos. Toxicology and Applied Pharmacology 2002;181(2):142-151. R826886 (2000)
    not available
    Journal Article Lu CS, Knutson DE, Fisker-Andersen J, Fenske RA. Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle metropolitan area. Environmental Health Perspectives 2001;109(3):299-303.
    abstract available  
    R826886 (2000)
    R825171 (2000)
    not available
    Journal Article Lu C, Fenske RA. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environmental Health Perspectives 1999;107(6):463-467.
    abstract available   full text available
    R826886 (2000)
    R826886C004 (2001)
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Environmental Health Perspectives Full Text
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  • Journal Article Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000;84(3):290-302.
    abstract available   full text available
    R826886 (2000)
    R826886C004 (2001)
  • Abstract from PubMed
  • Other: Science Direct PDF
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  • Journal Article Mendoza MAC, Ponce RA, Ou YC, Faustman EM. p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicology and Applied Pharmacology 2002;178(2):117-125.
    abstract available   full text available
    R826886 (2000)
    R825358 (Final)
  • Abstract from PubMed
  • Full-text: Science Direct PDF
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  • Abstract: Science Direct
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  • Journal Article Mirkes PE, Little SA. Teratogen-induced cell death in postimplantation mouse embryos:differential tissue sensitivity and hallmarks of apoptosis. Cell Death and Differentiation 1998;5(7):592-600. R826886 (2000)
    not available
    Journal Article Mirkes PE, Cornel LM, Wilson KL, Dilmann WH. Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. Developmental Dynamics 1999;214(2):159-170. R826886 (2000)
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    Journal Article Mirkes PE, Little SA. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicology and Applied Pharmacology 2000;162(3):197-206.
    abstract available   full text available
    R826886 (2000)
    R826886C001 (2001)
  • Abstract from PubMed
  • Other: Science Direct PDF
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  • Journal Article Mirkes PE, Wilson KL, Cornel LM. Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. Teratology 2000;62(1):14-25.
    abstract available  
    R826886 (2000)
    R826886C001 (2001)
  • Abstract from PubMed
  • Journal Article Mirkes PE. 2001 Warkany lecture:to die or not to die, the role of apoptosis in normal and abnormal mammalian development. Teratology 2002;65(5):228-239. R826886 (2000)
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    Journal Article Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA. Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. Journal of Analytical Toxicology 1999;23(4):230-236.
    abstract available  
    R826886 (2000)
    R826886C004 (2001)
    R825171 (1999)
    R825171 (2000)
  • Abstract from PubMed
  • Journal Article Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA. Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. Journal of the AOAC International 2002;85(1):36-43.
    abstract available  
    R826886 (2000)
    R826886C004 (2001)
    R826886C004 (2002)
  • Abstract from PubMed
  • Journal Article Namgung U, Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. Journal of Neuroscience 2000;20(17):6442-6451. R826886 (2000)
    not available
    Journal Article Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicology and Applied Pharmacology 2001;174(2):130-138.
    abstract available   full text available
    R826886 (2000)
    R826886C001 (2002)
  • Abstract from PubMed
  • Other: Science Direct PDF
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  • Journal Article Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology 1999;157(3):203-212.
    abstract available   full text available
    R826886 (2000)
    R825358 (Final)
  • Abstract from PubMed
  • Full-text: Science Direct PDF
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  • Abstract: Science Direct
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  • Journal Article Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology 1999;20(5):793-804.
    abstract available  
    R826886 (2000)
    R825358 (Final)
  • Abstract from PubMed
  • Journal Article Polifka JE, Faustman EM. Developmental toxicity:web resources for evaluating risk in humans. Toxicology 2002;173(1-2):35-65. R826886 (2000)
    not available
    Journal Article Ponce RA, Bartell SM, Wong EY, LaFlamme D, Carrington C, Lee RC, Patrick DL, Faustman EM, Bloger M. Use of quality-adjusted life year weights with dose-response models for public health decisions:A case study of the risks and benefits of fish consumption. Risk Analysis 2000;20:529-542. R826886 (2000)
    not available
    Journal Article Ponce RA, Wong EY, Faustman EM. Quality adjusted life years (QALYs) and dose-response models in environmental health policy analysis--methodological considerations. Science of the Total Environment 2001; 274(1-3):79-91. R826886 (2000)
    not available
    Journal Article Poser S, Impey S, Trinh K, Xia Z, Storm DR. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO Journal 2000;19(18):4955-4966. R826886 (2000)
    not available
    Journal Article Richter RJ, Furlong CE. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 1999;9(6):745-753. R826886 (2000)
    not available
    Journal Article Sanga RN, Bartell SM, Ponce RA, Boischio AAP, Joiris CR, Pierce CH, Faustman EM. Effects of uncertainties on exposure estimates to methylmercury:A Monte Carlo analysis of biomarkers of exposure vs. predictive dietary estimation. Risk Analysis 2001;21(5):859-868. R826886 (2000)
    not available
    Journal Article Thompson B, Coronado G, Puschel K, Allen E. Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environmental Health Perspectives 2001;109(Suppl 3):443-448.
    abstract available   full text available
    R826886 (2000)
    R826886C003 (2001)
    R826886C003 (2002)
    R826886C004 (2001)
    R826886C004 (2002)
  • Abstract from PubMed
  • Full-text: Environmental Health Perspectives Full Text
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  • Other: Environmental Health Perspectives PDF
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  • Journal Article Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53.
    abstract available   full text available
    R826886 (2000)
    R826886C003 (2002)
    R831709 (2005)
    R831709 (2007)
    R831709C003 (2004)
  • Abstract from PubMed
  • Abstract: Lippincott, Williams & Wilkins-Abstract
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  • Journal Article Umpierre CC, Little SA, Mirkes PE. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 2001;63(3):134-143.
    abstract available  
    R826886 (2000)
    R826886C001 (2001)
    R826886C001 (2002)
  • Abstract from PubMed
  • Journal Article Vicini P, Pierce CH, Dills RL, Morgan MS, Kalman DA. Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. Risk Analysis 1999;19(6):1127-1134.
    abstract available  
    R826886 (2000)
  • Abstract from PubMed
  • Journal Article Wong EY, Shirai JH, Garlock TJ, Kissel JC. Adult proxy responses to a survey of children's dermal soil contact activities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Pt 1):509-517. R826886 (2000)
    not available
    Journal Article Wong EY, Shirai JH, Garlock TJ, Kissel JC. Survey of selected activities relevant to exposures to soils. Bulletin of Enviornmental Contaminants and Toxicology 2000;65(4):443-450. R826886 (2000)
    not available
    Journal Article Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf Jr. WE, Feuerstein GZ. TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. Journal of Biological Chemistry 1999;274(3):1479-1486. R826886 (2000)
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    Journal Article Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. Journal of Biological Chemistry 2002;277(25):22909-22914. R826886 (2000)
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    Supplemental Keywords:

    RFA, Health, Scientific Discipline, Geographic Area, Environmental Chemistry, Health Risk Assessment, Epidemiology, State, Risk Assessments, Biochemistry, Children's Health, health effects, pesticide exposure, developmental neurotoxicology, environmental health, developmental neurotoxicity, exposure, pesticides, developmental effects, epidemelogy, developmental toxicity, children, Human Health Risk Assessment, neurotoxicity, Washington (WA), human exposure, insecticides, children's vulnerablity, assessment of exposure, harmful environmental agents, epidemeology, environmental health hazard, children's environmental health, growth & development, agricultural community, developmental disorders, exposure assessment, human health risk, organophosphate pesticides

    Progress and Final Reports:
    2000 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826886C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
    R826886C002 Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
    R826886C003 Community-Based Participatory Research Project
    R826886C004 Pesticide Exposure Pathways Research Project

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