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Extramural Research

Grantee Research Project Results

NCER Grantee Research Project Results

Possible Estrogenic Effects of Hog Waste Runoff on the Aquatic Environment

EPA Grant Number: U915461
Title: Possible Estrogenic Effects of Hog Waste Runoff on the Aquatic Environment
Investigators: Rau, Michelle
Institution: Duke University
EPA Project Officer: Manty, Dale
Project Period: September 1, 1998 through September 1, 2001
Project Amount: $102,000
RFA: STAR Graduate Fellowships (1998)
Research Category: Fellowship - Toxicology , Health Effects , Academic Fellowships

Description:

Objective:

The objectives of this research project are to: (1) characterize the estrogenic compounds present in runoff from hog waste operations; and (2) examine the potential estrogenic effects of this runoff on the aquatic environment.

Approach:

This research will provide a preliminary assessment of the potential estrogenic activity of hog waste and the potential impacts on aquatic ecosystems. First, I will determine the prevalence of estrogenic compounds in hog waste contained in lagoons. The estrogenic activity of the hog waste will be determined in the laboratory by exposing killifish, Fundulus heteroclitus, to hog waste and assessing vitellogenin (a biomarker for estrogen exposure) production in male fish. The estrogenic effects of the hog waste runoff on wild fish populations will be assessed in a similar manner by collecting killifish from streams adjacent to hog farming operations and by examining male vitellogenin production.

Supplemental Keywords:

fellowship, hog waste, runoff, estrogenic compounds., RFA, Health, Scientific Discipline, Genetics, Chemistry, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Biochemistry, genetic susceptability, metabolic engineering, Molecular Biology/Genetics, Biology, cancer risk, channel catfish, mutagenic properties, carcinogenesis, cellular metabolism, comparative metabolism, benzopyrene, liver cancer, PAH, DNA adducts, Hepatitis, molecular approach, DNA repair studies, nucleotide excision repair (NER), conceptual models, molecular biology, DNA repair, adaptation, carcinogenic

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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