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Extramural Research

2003 Progress Report: Study of Phthalates in Pregnant Woman and Children

EPA Grant Number: R829436
Title: Study of Phthalates in Pregnant Woman and Children
Investigators: Swan, Shanna H. , Calafat, Antonia , Drobnis, Erma , Lasley, Bill L. , Redmon, J. Bruce , Sparks, Amy , Wang, Christina
Current Investigators: Swan, Shanna H. , Calafat, Antonia , Kruse, Robin , Lasley, Bill L. , Redmon, Bruce , Sparks, Amy , Wang, Christina
Institution: University of Missouri - Columbia , Centers for Disease Control and Prevention , University of California - Davis , University of Iowa , University of Minnesota
Current Institution: University of Rochester , CDC , Harbor-UCLA Medical Center , University of California - Davis , University of Iowa , University of Minnesota , University of Missouri - Columbia
EPA Project Officer: Glenn, Barbara
Project Period: August 1, 2001 through January 31, 2005 (Extended to July 31, 2007)
Project Period Covered by this Report: August 1, 2002 through January 31, 2003
Project Amount: $2,779,164
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001)
Research Category: Economics and Decision Sciences , Endocrine Disruptors

Description:

Objective:

The overall objective of this research project is to assess the risks posed by environmental phthalate levels to reproductive health. The research will address the following questions:

  1. Does in utero phthalate exposure alter breast and genital development?
  2. How do infants’ pre- and postnatal sensitivity to phthalates compare?
  3. What are the major sources of phthalate exposure for pregnant women and infants?
  4. Do phthalate metabolite levels vary with ethnicity and geography?
  5. Do genital and breast measurements vary with ethnicity and geography?
  6. How is phthalate metabolism altered by pregnancy?

Progress Summary:

By September 30, 2003, we had recruited 364 mothers and their babies (359 singletons and 10 pairs of twins). We also had conducted a total of 399 baby exams (354 first exams, 45 second exams), and collected 334 baby urine samples (at first exam) and 360 maternal urine samples. In addition, we developed databases and conducted statistical analyses on the first 200 mother-child pairs.

Future Activities:

During Year 3 of the project, we will:

  1. continue baby exams (expect N = 150 Year 3),
  2. obtain urine phthalate measurements on the first 200 mother-child pairs,
  3. obtain hormone levels on babies examined by 12 months as of March 1, 2004 (N = 111),
  4. complete database entry and cleaning for baby exams and mothers’ questionnaires for the first 400 subjects,
  5. and complete a paper on the reliability and feasibility of infant genital and breast exams.

Journal Articles:

No journal articles submitted with this report: View all 34 publications for this project

Supplemental Keywords:

phthalates, prenatal exposure, sexual development, geography, endocrine, endocrine disruptors, epidemiology, ethnicity, infants, neonates, health, biochemistry, chemistry, environmental exposure and risk, human health, health risk assessment, risk assessments, susceptibility, sensitive population, genetic susceptibility, childhood development, children, developmental biology, developmental effects, endocrine disrupting chemicals, epidemiologic studies, exposure, exposure studies, human growth and development, infants, metabolites, pregnancy, pregnant women, reproductive health,, RFA, Health, Scientific Discipline, Health Risk Assessment, Chemistry, Epidemiology, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, genetic susceptability, Endocrine Disruptors - Human Health, childhood development, infants, metabolites, prenatal exposure, endocrine disrupting chemicals, exposure, exposure studies, sexual development, developmental effects, children, developmental biology, human growth and development, pregnant women, pregnancy, reproductive health, phthalates, epidemiologic studies

Relevant Websites:

http://www.missouri.edu/~sff Exit

Progress and Final Reports:
Original Abstract
2002 Progress Report
2005 Progress Report
2006 Progress Report
Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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